Trait
Excessive sweating
Clinical name: Hyperhidrosis
Abnormal excessive perspiration (sweating) despite the lack of appropriate stimuli like hot and humid weather.
Summary
- Also called
- Increased sweating, Profuse sweating, Sweating, Sweating profusely, Sweating, increased, Diaphoresis
- Body system
- Abnormality of the integument
Reference genomeGRCh38hg38
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Get my Genome Test137 genes linked to Excessive sweating
Changes in these genes cause rare conditions in which Excessive sweating is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| BOLA3bolA family member 3 | Always | In 1 condition |
| DSG1desmoglein 1 | Always | In 1 condition |
| IRF4interferon regulatory factor 4 | Always | In 1 condition |
| LIFRLIF receptor subunit alpha | Always | In 2 conditions |
| MAP2K1mitogen-activated protein kinase kinase 1 | Always | In 2 conditions |
| MAP2K2mitogen-activated protein kinase kinase 2 | Always | In 2 conditions |
| SHQ1SHQ1, H/ACA ribonucleoprotein assembly factor | Always | In 1 condition |
| SLC18A2solute carrier family 18 member A2 | Always | In 2 conditions |
| SUCLG1succinate-CoA ligase GDP/ADP-forming subunit alpha | Always | In 2 conditions |
| AIPAHR interacting HSP90 co-chaperone | Very often (80–99%) | In 2 conditions |
| AQP5aquaporin 5 | Very often (80–99%) | In 1 condition |
| BCL10BCL10 immune signaling adaptor | Very often (80–99%) | In 1 condition |
| BIRC3baculoviral IAP repeat containing 3 | Very often (80–99%) | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Very often (80–99%) | In 2 conditions |
| CACNA1Scalcium voltage-gated channel subunit alpha1 S | Very often (80–99%) | In 1 condition |
| CLCF1cardiotrophin like cytokine factor 1 | Very often (80–99%) | In 1 condition |
| CRLF1cytokine receptor like factor 1 | Very often (80–99%) | In 2 conditions |
| ELP1elongator acetyltransferase complex subunit 1 | Very often (80–99%) | In 1 condition |
| FOXP1forkhead box P1 | Very often (80–99%) | In 1 condition |
| FUCA1alpha-L-fucosidase 1 | Very often (80–99%) | In 1 condition |
| GABRA3gamma-aminobutyric acid type A receptor subunit alpha3 | Very often (80–99%) | In 1 condition |
| GPR101G protein-coupled receptor 101 | Very often (80–99%) | In 2 conditions |
| HNF4Ahepatocyte nuclear factor 4 alpha | Very often (80–99%) | In 1 condition |
| HPGD15-hydroxyprostaglandin dehydrogenase | Very often (80–99%) | In 3 conditions |
| IGHimmunoglobulin heavy locus | Very often (80–99%) | In 1 condition |
| KCNJ18potassium inwardly rectifying channel subfamily J member 18 | Very often (80–99%) | In 1 condition |
| KIF1Akinesin family member 1A | Very often (80–99%) | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Very often (80–99%) | In 1 condition |
| MALT1MALT1 paracaspase | Very often (80–99%) | In 1 condition |
| MEN1menin 1 | Very often (80–99%) | In 2 conditions |
| NLRP3NLR family pyrin domain containing 3 | Very often (80–99%) | In 1 condition |
| PHOX2Bpaired like homeobox 2B | Very often (80–99%) | In 2 conditions |
| RETREG1reticulophagy regulator 1 | Very often (80–99%) | In 1 condition |
| SCN9Asodium voltage-gated channel alpha subunit 9 | Very often (80–99%) | In 2 conditions |
| SERPINB7serpin family B member 7 | Very often (80–99%) | In 1 condition |
| SLCO2A1solute carrier organic anion transporter family member 2A1 | Very often (80–99%) | In 3 conditions |
| WNK1WNK lysine deficient protein kinase 1 | Very often (80–99%) | In 1 condition |
| YY1YY1 transcription factor | Very often (80–99%) | In 1 condition |
| ACDACD shelterin complex subunit and telomerase recruitment factor | Often (30–79%) | In 1 condition |
| CDH23cadherin related 23 | Often (30–79%) | In 1 condition |
Show 97 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| CDKN2Acyclin dependent kinase inhibitor 2A | Often (30–79%) | In 1 condition |
| CLCN6Cl-/H+ antiporter 6 | Often (30–79%) | In 1 condition |
| CTC1CST telomere replication complex component 1 | Often (30–79%) | In 1 condition |
| CTNNB1catenin beta 1 | Often (30–79%) | In 1 condition |
| CTSHcathepsin H | Often (30–79%) | In 1 condition |
| DDCdopa decarboxylase | Often (30–79%) | In 2 conditions |
| DKC1dyskerin pseudouridine synthase 1 | Often (30–79%) | In 2 conditions |
| DSTdystonin | Often (30–79%) | In 1 condition |
| FGFR2fibroblast growth factor receptor 2 | Often (30–79%) | In 2 conditions |
| FLRT1fibronectin leucine rich transmembrane protein 1 | Often (30–79%) | In 1 condition |
| GNA14G protein subunit alpha 14 | Often (30–79%) | In 2 conditions |
| HCRThypocretin neuropeptide precursor | Often (30–79%) | In 1 condition |
| HLA-DQB1major histocompatibility complex, class II, DQ beta 1 | Often (30–79%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Often (30–79%) | In 2 conditions |
| JAK2Janus kinase 2 | Often (30–79%) | In 1 condition |
| JUPjunction plakoglobin | Often (30–79%) | In 1 condition |
| KCNA1potassium voltage-gated channel subfamily A member 1 | Often (30–79%) | In 1 condition |
| KLC2kinesin light chain 2 | Often (30–79%) | In 2 conditions |
| MOGmyelin oligodendrocyte glycoprotein | Often (30–79%) | In 1 condition |
| MPLMPL proto-oncogene, thrombopoietin receptor | Often (30–79%) | In 1 condition |
| NGLY1N-glycanase 1 | Often (30–79%) | In 1 condition |
| NHP2NHP2 ribonucleoprotein | Often (30–79%) | In 1 condition |
| NOP10NOP10 ribonucleoprotein | Often (30–79%) | In 1 condition |
| NPM1nucleophosmin 1 | Often (30–79%) | In 1 condition |
| P2RY11purinergic receptor P2Y11 | Often (30–79%) | In 1 condition |
| PARNpoly(A)-specific ribonuclease | Often (30–79%) | In 1 condition |
| PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha | Often (30–79%) | In 1 condition |
| PRNPprion protein (Kanno blood group) | Often (30–79%) | In 2 conditions |
| RTEL1regulator of telomere elongation helicase 1 | Often (30–79%) | In 1 condition |
| SLC16A2solute carrier family 16 member 2 | Often (30–79%) | In 1 condition |
| SLURP1secreted LY6/PLAUR domain containing 1 | Often (30–79%) | In 2 conditions |
| SPRsepiapterin reductase | Often (30–79%) | In 1 condition |
| SUCLA2succinate-CoA ligase ADP-forming subunit beta | Often (30–79%) | In 1 condition |
| TATtyrosine aminotransferase | Often (30–79%) | In 1 condition |
| TERCtelomerase RNA component | Often (30–79%) | In 1 condition |
| TERTtelomerase reverse transcriptase | Often (30–79%) | In 2 conditions |
| THPOthrombopoietin | Often (30–79%) | In 1 condition |
| TINF2TERF1 interacting nuclear factor 2 | Often (30–79%) | In 1 condition |
| TNFSF4TNF superfamily member 4 | Often (30–79%) | In 1 condition |
| TP53tumor protein p53 | Often (30–79%) | In 1 condition |
| TRANK1tetratricopeptide repeat and ankyrin repeat containing 1 | Often (30–79%) | In 1 condition |
| TYMSthymidylate synthetase | Often (30–79%) | In 1 condition |
| USB1U6 snRNA biogenesis phosphodiesterase 1 | Often (30–79%) | In 1 condition |
| WRAP53WD repeat containing antisense to TP53 | Often (30–79%) | In 1 condition |
| ZNF365zinc finger protein 365 | Often (30–79%) | In 1 condition |
| ZNRF3zinc and ring finger 3 | Often (30–79%) | In 1 condition |
| ATP1A2ATPase Na+/K+ transporting subunit alpha 2 | Sometimes (5–29%) | In 1 condition |
| ATP1A3ATPase Na+/K+ transporting subunit alpha 3 | Sometimes (5–29%) | In 1 condition |
| CACNA1Acalcium voltage-gated channel subunit alpha1 A | Sometimes (5–29%) | In 1 condition |
| CCND1cyclin D1 | Sometimes (5–29%) | In 1 condition |
| CNBPCCHC-type zinc finger nucleic acid binding protein | Sometimes (5–29%) | In 1 condition |
| COL17A1collagen type XVII alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| CTSBcathepsin B | Sometimes (5–29%) | In 1 condition |
| CUL4Bcullin 4B | Sometimes (5–29%) | In 1 condition |
| FBXO11F-box protein 11 | Sometimes (5–29%) | In 1 condition |
| GRB10growth factor receptor bound protein 10 | Sometimes (5–29%) | In 1 condition |
| HLA-Bmajor histocompatibility complex, class I, B | Sometimes (5–29%) | In 1 condition |
| HNRNPKheterogeneous nuclear ribonucleoprotein K | Sometimes (5–29%) | In 2 conditions |
| KRT1keratin 1 | Sometimes (5–29%) | In 1 condition |
| KRT14keratin 14 | Sometimes (5–29%) | In 1 condition |
| KRT16keratin 16 | Sometimes (5–29%) | In 1 condition |
| KRT5keratin 5 | Sometimes (5–29%) | In 1 condition |
| KRT9keratin 9 | Sometimes (5–29%) | In 1 condition |
| MT-TL2mitochondrially encoded tRNA-Leu (CUN) 2 | Sometimes (5–29%) | In 1 condition |
| P4HA2prolyl 4-hydroxylase subunit alpha 2 | Sometimes (5–29%) | In 1 condition |
| PLAAphospholipase A2 activating protein | Sometimes (5–29%) | In 1 condition |
| PTPN22protein tyrosine phosphatase non-receptor type 22 | Sometimes (5–29%) | In 1 condition |
| RHOBTB2Rho related BTB domain containing 2 | Sometimes (5–29%) | In 1 condition |
| SCN2Asodium voltage-gated channel alpha subunit 2 | Sometimes (5–29%) | In 1 condition |
| SLC1A3solute carrier family 1 member 3 | Sometimes (5–29%) | In 1 condition |
| SLC2A1solute carrier family 2 member 1 | Sometimes (5–29%) | In 1 condition |
| SLC39A14solute carrier family 39 member 14 | Sometimes (5–29%) | In 1 condition |
| SPRED2sprouty related EVH1 domain containing 2 | Sometimes (5–29%) | In 1 condition |
| TRPV3transient receptor potential cation channel subfamily V member 3 | Sometimes (5–29%) | In 1 condition |
| VHLvon Hippel-Lindau tumor suppressor | Sometimes (5–29%) | In 2 conditions |
| WNT10AWnt family member 10A | Sometimes (5–29%) | In 1 condition |
| CLCNKBchloride voltage-gated channel Kb | Rarely (1–4%) | In 1 condition |
| GLAgalactosidase alpha | Rarely (1–4%) | In 1 condition |
| H19H19 imprinted maternally expressed transcript | Rarely (1–4%) | In 1 condition |
| HINT1histidine triad nucleotide binding protein 1 | Rarely (1–4%) | In 2 conditions |
| HMBShydroxymethylbilane synthase | Rarely (1–4%) | In 1 condition |
| HRASHRas proto-oncogene, GTPase | Rarely (1–4%) | In 1 condition |
| IGF2insulin like growth factor 2 | Rarely (1–4%) | In 1 condition |
| NTRK1neurotrophic receptor tyrosine kinase 1 | Rarely (1–4%) | In 1 condition |
| SLC12A3solute carrier family 12 member 3 | Rarely (1–4%) | In 1 condition |
| COL6A1collagen type VI alpha 1 chain | Not recorded | In 1 condition |
| HEXBhexosaminidase subunit beta | Not recorded | In 1 condition |
| IGHMBP2immunoglobulin mu DNA binding protein 2 | Not recorded | In 1 condition |
| KIF1Bkinesin family member 1B | Not recorded | In 1 condition |
| KRT6Akeratin 6A | Not recorded | In 1 condition |
| MAXMYC associated transcriptional regulator X | Not recorded | In 1 condition |
| RETret proto-oncogene | Not recorded | In 1 condition |
| SCN11Asodium voltage-gated channel alpha subunit 11 | Not recorded | In 1 condition |
| SDHBsuccinate dehydrogenase complex iron sulfur subunit B | Not recorded | In 1 condition |
| SDHCsuccinate dehydrogenase complex subunit C | Not recorded | In 1 condition |
| SDHDsuccinate dehydrogenase complex subunit D | Not recorded | In 1 condition |
| TMEM127transmembrane protein 127 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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