Trait
Increased body weight
Abnormally increased body weight.
Summary
- Also called
- Weight gain
- Body system
- Growth abnormality
Reference genomeGRCh38hg38
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Get my Genome Test40 genes linked to Increased body weight
Changes in these genes cause rare conditions in which Increased body weight is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CHASERRCHD2 adjacent suppressive regulatory RNA | Always | In 1 condition |
| DSTdystonin | Always | In 1 condition |
| FDXRferredoxin reductase | Always | In 1 condition |
| NSD1nuclear receptor binding SET domain protein 1 | Always | In 1 condition |
| RNU2-2RNA, U2 small nuclear 2 | Always | In 1 condition |
| THRBthyroid hormone receptor beta | Always | In 1 condition |
| YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta | Always | In 1 condition |
| ATP7BATPase copper transporting beta | Very often (80–99%) | In 1 condition |
| HNF4Ahepatocyte nuclear factor 4 alpha | Very often (80–99%) | In 1 condition |
| ATRXATRX chromatin remodeler | Often (30–79%) | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Often (30–79%) | In 1 condition |
| CD46CD46 molecule | Often (30–79%) | In 1 condition |
| CDH23cadherin related 23 | Often (30–79%) | In 1 condition |
| CDKN2Acyclin dependent kinase inhibitor 2A | Often (30–79%) | In 1 condition |
| CFHcomplement factor H | Often (30–79%) | In 1 condition |
| CFIcomplement factor I | Often (30–79%) | In 1 condition |
| CTNNB1catenin beta 1 | Often (30–79%) | In 1 condition |
| HELLPARHELLP associated long non-coding RNA | Often (30–79%) | In 1 condition |
| MAGEL2MAGE family member L2 | Often (30–79%) | In 1 condition |
| MEN1menin 1 | Often (30–79%) | In 1 condition |
| NR3C1nuclear receptor subfamily 3 group C member 1 | Often (30–79%) | In 1 condition |
| PHIPPHIP subunit of CUL4-Ring ligase complex | Often (30–79%) | In 1 condition |
| PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha | Often (30–79%) | In 2 conditions |
| RAI1retinoic acid induced 1 | Often (30–79%) | In 1 condition |
| TERTtelomerase reverse transcriptase | Often (30–79%) | In 1 condition |
| TP53tumor protein p53 | Often (30–79%) | In 2 conditions |
| USP48ubiquitin specific peptidase 48 | Often (30–79%) | In 1 condition |
| USP8ubiquitin specific peptidase 8 | Often (30–79%) | In 1 condition |
| YY1YY1 transcription factor | Often (30–79%) | In 1 condition |
| ZNRF3zinc and ring finger 3 | Often (30–79%) | In 1 condition |
| ARMC5armadillo repeat containing 5 | Sometimes (5–29%) | In 2 conditions |
| GNASGNAS complex locus | Sometimes (5–29%) | In 1 condition |
| KDM1Alysine demethylase 1A | Sometimes (5–29%) | In 1 condition |
| PDE11Aphosphodiesterase 11A | Sometimes (5–29%) | In 1 condition |
| UBE2Aubiquitin conjugating enzyme E2 A | Sometimes (5–29%) | In 1 condition |
| PHKA2phosphorylase kinase regulatory subunit alpha 2 | Rarely (1–4%) | In 1 condition |
| PHKBphosphorylase kinase regulatory subunit beta | Rarely (1–4%) | In 1 condition |
| PHKG2phosphorylase kinase catalytic subunit gamma 2 | Rarely (1–4%) | In 1 condition |
| PRKACAprotein kinase cAMP-activated catalytic subunit alpha | Not recorded | In 1 condition |
| THRAthyroid hormone receptor alpha | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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