Trait
Jaundice
Yellow pigmentation of the skin due to bilirubin, which in turn is the result of increased bilirubin concentration in the bloodstream.
Summary
- Also called
- Yellow skin, Yellowing of the skin, Icterus
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test192 genes linked to Jaundice
Changes in these genes cause rare conditions in which Jaundice is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ABCB11ATP binding cassette subfamily B member 11 | Always | In 3 conditions |
| ABCB4ATP binding cassette subfamily B member 4 | Always | In 4 conditions |
| ABCD3ATP binding cassette subfamily D member 3 | Always | In 1 condition |
| ALDOAaldolase, fructose-bisphosphate A | Always | In 1 condition |
| ATP11CATPase phospholipid transporting 11C (ATP11C blood group) | Always | In 1 condition |
| ATP8B1ATPase phospholipid transporting 8B1 | Always | In 4 conditions |
| BAATbile acid-CoA:amino acid N-acyltransferase | Always | In 1 condition |
| CASKcalcium/calmodulin dependent serine protein kinase | Always | In 1 condition |
| CILK1ciliogenesis associated kinase 1 | Always | In 1 condition |
| CLDN1claudin 1 | Always | In 2 conditions |
| COG7component of oligomeric golgi complex 7 | Always | In 2 conditions |
| CYP7B1cytochrome P450 family 7 subfamily B member 1 | Always | In 2 conditions |
| DCDC2doublecortin domain containing 2 | Always | In 1 condition |
| EPB42erythrocyte membrane protein band 4.2 | Always | In 2 conditions |
| G6PDglucose-6-phosphate dehydrogenase | Always | In 1 condition |
| GALEUDP-galactose-4-epimerase | Always | In 1 condition |
| GALTgalactose-1-phosphate uridylyltransferase | Always | In 2 conditions |
| HK1hexokinase 1 | Always | In 1 condition |
| IARS1isoleucyl-tRNA synthetase 1 | Always | In 1 condition |
| IFT56intraflagellar transport 56 | Always | In 1 condition |
| IL18BPinterleukin 18 binding protein | Always | In 1 condition |
| ITPR3inositol 1,4,5-trisphosphate receptor type 3 | Always | In 1 condition |
| KDM6Blysine demethylase 6B | Always | In 1 condition |
| KIF12kinesin family member 12 | Always | In 1 condition |
| KYNUkynureninase | Always | In 1 condition |
| LRRC7leucine rich repeat containing 7 | Always | In 1 condition |
| LSM7LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated | Always | In 1 condition |
| LYNLYN proto-oncogene, Src family tyrosine kinase | Always | In 1 condition |
| MCCC1methylcrotonyl-CoA carboxylase subunit 1 | Always | In 1 condition |
| MED12mediator complex subunit 12 | Always | In 1 condition |
| PEX1peroxisomal biogenesis factor 1 | Always | In 2 conditions |
| PEX14peroxisomal biogenesis factor 14 | Always | In 2 conditions |
| PEX26peroxisomal biogenesis factor 26 | Always | In 2 conditions |
| PKD2polycystin 2, transient receptor potential cation channel | Always | In 1 condition |
| PKLRpyruvate kinase L/R | Always | In 1 condition |
| POLG2DNA polymerase gamma 2, accessory subunit | Always | In 1 condition |
| PSKH1protein serine kinase H1 | Always | In 1 condition |
| PTCRApre T cell antigen receptor alpha | Always | In 1 condition |
| RNU6ATACRNA, U6atac small nuclear | Always | In 1 condition |
| SCO2synthesis of cytochrome C oxidase 2 | Always | In 1 condition |
Show 152 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| SLC2A1solute carrier family 2 member 1 | Always | In 2 conditions |
| SPTBspectrin beta, erythrocytic | Always | In 3 conditions |
| TCP1t-complex 1 | Always | In 1 condition |
| TMEM63Btransmembrane protein 63B | Always | In 1 condition |
| TRMUtRNA mitochondrial 2-thiouridylase | Always | In 1 condition |
| UGT1A1UDP glucuronosyltransferase family 1 member A1 | Always | In 4 conditions |
| UROSuroporphyrinogen III synthase | Always | In 1 condition |
| VPS33BVPS33B late endosome and lysosome associated | Always | In 2 conditions |
| ABCC2ATP binding cassette subfamily C member 2 | Very often (80–99%) | In 2 conditions |
| ANK1ankyrin 1 | Very often (80–99%) | In 2 conditions |
| ATP7BATPase copper transporting beta | Very often (80–99%) | In 2 conditions |
| BRCA1BRCA1 DNA repair associated | Very often (80–99%) | In 2 conditions |
| BRCA2BRCA2 DNA repair associated | Very often (80–99%) | In 2 conditions |
| HSD3B7hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | Very often (80–99%) | In 2 conditions |
| MYO5Bmyosin VB | Very often (80–99%) | In 1 condition |
| NKX2-5NK2 homeobox 5 | Very often (80–99%) | In 1 condition |
| PAX8paired box 8 | Very often (80–99%) | In 2 conditions |
| PEX10peroxisomal biogenesis factor 10 | Very often (80–99%) | In 1 condition |
| PEX11Bperoxisomal biogenesis factor 11 beta | Very often (80–99%) | In 1 condition |
| PEX12peroxisomal biogenesis factor 12 | Very often (80–99%) | In 1 condition |
| PEX13peroxisomal biogenesis factor 13 | Very often (80–99%) | In 1 condition |
| PEX16peroxisomal biogenesis factor 16 | Very often (80–99%) | In 2 conditions |
| PEX19peroxisomal biogenesis factor 19 | Very often (80–99%) | In 1 condition |
| PEX2peroxisomal biogenesis factor 2 | Very often (80–99%) | In 2 conditions |
| PEX3peroxisomal biogenesis factor 3 | Very often (80–99%) | In 1 condition |
| PEX5peroxisomal biogenesis factor 5 | Very often (80–99%) | In 2 conditions |
| PEX6peroxisomal biogenesis factor 6 | Very often (80–99%) | In 1 condition |
| PRF1perforin 1 | Very often (80–99%) | In 2 conditions |
| PTPN3protein tyrosine phosphatase non-receptor type 3 | Very often (80–99%) | In 1 condition |
| ROS1ROS proto-oncogene 1, receptor tyrosine kinase | Very often (80–99%) | In 1 condition |
| SLC25A13solute carrier family 25 member 13 | Very often (80–99%) | In 1 condition |
| SLC26A4solute carrier family 26 member 4 | Very often (80–99%) | In 1 condition |
| SLCO1B1solute carrier organic anion transporter family member 1B1 | Very often (80–99%) | In 2 conditions |
| SLCO1B3solute carrier organic anion transporter family member 1B3 | Very often (80–99%) | In 2 conditions |
| TSHRthyroid stimulating hormone receptor | Very often (80–99%) | In 1 condition |
| ADAMTS13ADAM metallopeptidase with thrombospondin type 1 motif 13 | Often (30–79%) | In 1 condition |
| AKR1D1aldo-keto reductase family 1 member D1 | Often (30–79%) | In 2 conditions |
| ATP7AATPase copper transporting alpha | Often (30–79%) | In 1 condition |
| CDKN2Acyclin dependent kinase inhibitor 2A | Often (30–79%) | In 1 condition |
| DEF6DEF6 guanine nucleotide exchange factor | Often (30–79%) | In 1 condition |
| FOCADfocadhesin | Often (30–79%) | In 1 condition |
| GPIglucose-6-phosphate isomerase | Often (30–79%) | In 2 conditions |
| HBBhemoglobin subunit beta | Often (30–79%) | In 5 conditions |
| IL12Ainterleukin 12A | Often (30–79%) | In 1 condition |
| IL12RB1interleukin 12 receptor subunit beta 1 | Often (30–79%) | In 1 condition |
| IRF5interferon regulatory factor 5 | Often (30–79%) | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Often (30–79%) | In 1 condition |
| MMEL1membrane metalloendopeptidase like 1 | Often (30–79%) | In 1 condition |
| MPV17mitochondrial inner membrane protein MPV17 | Often (30–79%) | In 1 condition |
| MTR5-methyltetrahydrofolate-homocysteine methyltransferase | Often (30–79%) | In 1 condition |
| NPC2NPC intracellular cholesterol transporter 2 | Often (30–79%) | In 1 condition |
| NR1H4nuclear receptor subfamily 1 group H member 4 | Often (30–79%) | In 2 conditions |
| PALB2partner and localizer of BRCA2 | Often (30–79%) | In 1 condition |
| PALLDpalladin, cytoskeletal associated protein | Often (30–79%) | In 1 condition |
| PFKMphosphofructokinase, muscle | Often (30–79%) | In 1 condition |
| PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin | Often (30–79%) | In 2 conditions |
| POLGDNA polymerase gamma, catalytic subunit | Often (30–79%) | In 1 condition |
| POU2AF1POU class 2 homeobox associating factor 1 | Often (30–79%) | In 1 condition |
| RAB27ARAB27A, member RAS oncogene family | Often (30–79%) | In 1 condition |
| RABL3RAB, member of RAS oncogene family like 3 | Often (30–79%) | In 1 condition |
| RHAGRh associated glycoprotein | Often (30–79%) | In 3 conditions |
| SERPINA1serpin family A member 1 | Often (30–79%) | In 1 condition |
| SLC4A1solute carrier family 4 member 1 (Diego blood group) | Often (30–79%) | In 3 conditions |
| SMAD4SMAD family member 4 | Often (30–79%) | In 1 condition |
| SPIBSpi-B transcription factor | Often (30–79%) | In 1 condition |
| SPTA1spectrin alpha, erythrocytic 1 | Often (30–79%) | In 2 conditions |
| STX11syntaxin 11 | Often (30–79%) | In 2 conditions |
| TFAMtranscription factor A, mitochondrial | Often (30–79%) | In 1 condition |
| TNFSF15TNF superfamily member 15 | Often (30–79%) | In 1 condition |
| TNPO3transportin 3 | Often (30–79%) | In 1 condition |
| TP53tumor protein p53 | Often (30–79%) | In 1 condition |
| ZFYVE19zinc finger FYVE-type containing 19 | Often (30–79%) | In 1 condition |
| ACADVLacyl-CoA dehydrogenase very long chain | Sometimes (5–29%) | In 1 condition |
| ALDOBaldolase, fructose-bisphosphate B | Sometimes (5–29%) | In 2 conditions |
| ALG6ALG6 alpha-1,3-glucosyltransferase | Sometimes (5–29%) | In 1 condition |
| ALG8ALG8 alpha-1,3-glucosyltransferase | Sometimes (5–29%) | In 1 condition |
| CA5Acarbonic anhydrase 5A | Sometimes (5–29%) | In 1 condition |
| CALRcalreticulin | Sometimes (5–29%) | In 1 condition |
| CASRcalcium sensing receptor | Sometimes (5–29%) | In 1 condition |
| COX4I2cytochrome c oxidase subunit 4I2 | Sometimes (5–29%) | In 1 condition |
| CPA1carboxypeptidase A1 | Sometimes (5–29%) | In 1 condition |
| CTRCchymotrypsin C | Sometimes (5–29%) | In 2 conditions |
| DPAGT1dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 | Sometimes (5–29%) | In 1 condition |
| DZIP1LDAZ interacting zinc finger protein 1 like | Sometimes (5–29%) | In 1 condition |
| EIF2AK3eukaryotic translation initiation factor 2 alpha kinase 3 | Sometimes (5–29%) | In 1 condition |
| EPB41erythrocyte membrane protein band 4.1 | Sometimes (5–29%) | In 2 conditions |
| F5coagulation factor V | Sometimes (5–29%) | In 1 condition |
| FCGR3BFc gamma receptor IIIb | Sometimes (5–29%) | In 1 condition |
| FLI1Fli-1 proto-oncogene, ETS transcription factor | Sometimes (5–29%) | In 1 condition |
| GCLCglutamate-cysteine ligase catalytic subunit | Sometimes (5–29%) | In 1 condition |
| GPR35G protein-coupled receptor 35 | Sometimes (5–29%) | In 1 condition |
| GYPCglycophorin C (Gerbich blood group) | Sometimes (5–29%) | In 1 condition |
| HBG2hemoglobin subunit gamma 2 | Sometimes (5–29%) | In 1 condition |
| HMGCL3-hydroxy-3-methylglutaryl-CoA lyase | Sometimes (5–29%) | In 1 condition |
| HNF1BHNF1 homeobox B | Sometimes (5–29%) | In 1 condition |
| HTRA2HtrA serine peptidase 2 | Sometimes (5–29%) | In 1 condition |
| JAK2Janus kinase 2 | Sometimes (5–29%) | In 1 condition |
| LBRlamin B receptor | Sometimes (5–29%) | In 2 conditions |
| LIPAlipase A, lysosomal acid type | Sometimes (5–29%) | In 1 condition |
| LRP5LDL receptor related protein 5 | Sometimes (5–29%) | In 1 condition |
| LYSTlysosomal trafficking regulator | Sometimes (5–29%) | In 2 conditions |
| MMACHCmetabolism of cobalamin associated C | Sometimes (5–29%) | In 1 condition |
| MST1macrophage stimulating 1 | Sometimes (5–29%) | In 1 condition |
| NAA10N-alpha-acetyltransferase 10, NatA catalytic subunit | Sometimes (5–29%) | In 1 condition |
| NEK8NIMA related kinase 8 | Sometimes (5–29%) | In 1 condition |
| NPHP3nephrocystin 3 | Sometimes (5–29%) | In 1 condition |
| OPLAH5-oxoprolinase, ATP-hydrolysing | Sometimes (5–29%) | In 1 condition |
| PIEZO1piezo type mechanosensitive ion channel component 1 (Er blood group) | Sometimes (5–29%) | In 1 condition |
| PIGAphosphatidylinositol glycan anchor biosynthesis class A | Sometimes (5–29%) | In 1 condition |
| PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha | Sometimes (5–29%) | In 1 condition |
| PRKCSHPRKCSH beta subunit of glucosidase II | Sometimes (5–29%) | In 1 condition |
| PRSS1serine protease 1 | Sometimes (5–29%) | In 1 condition |
| PRSS2serine protease 2 | Sometimes (5–29%) | In 1 condition |
| RHCERh blood group CcEe antigens | Sometimes (5–29%) | In 1 condition |
| RHDRh blood group D antigen | Sometimes (5–29%) | In 1 condition |
| SEC63SEC63 protein translocation regulator | Sometimes (5–29%) | In 1 condition |
| SEMA4Dsemaphorin 4D | Sometimes (5–29%) | In 1 condition |
| SLC30A10solute carrier family 30 member 10 | Sometimes (5–29%) | In 1 condition |
| SMPD1sphingomyelin phosphodiesterase 1 | Sometimes (5–29%) | In 1 condition |
| SP110SP110 nuclear body protein | Sometimes (5–29%) | In 1 condition |
| SPINK1serine peptidase inhibitor Kazal type 1 | Sometimes (5–29%) | In 1 condition |
| SPTBN1spectrin beta, non-erythrocytic 1 | Sometimes (5–29%) | In 1 condition |
| STXBP2syntaxin binding protein 2 | Sometimes (5–29%) | In 1 condition |
| TCF4transcription factor 4 | Sometimes (5–29%) | In 1 condition |
| TRPV6transient receptor potential cation channel subfamily V member 6 | Sometimes (5–29%) | In 1 condition |
| UNC13Dunc-13 homolog D | Sometimes (5–29%) | In 1 condition |
| IL2RGinterleukin 2 receptor subunit gamma | Rarely (1–4%) | In 1 condition |
| ATP6AP2ATPase H+ transporting accessory protein 2 | Not recorded | In 1 condition |
| CDIN1CDAN1 interacting nuclease 1 | Not recorded | In 1 condition |
| CPOXcoproporphyrinogen oxidase | Not recorded | In 1 condition |
| DGUOKdeoxyguanosine kinase | Not recorded | In 1 condition |
| DHFRdihydrofolate reductase | Not recorded | In 1 condition |
| ETFAelectron transfer flavoprotein subunit alpha | Not recorded | In 1 condition |
| ETFBelectron transfer flavoprotein subunit beta | Not recorded | In 1 condition |
| ETFDHelectron transfer flavoprotein dehydrogenase | Not recorded | In 1 condition |
| GLRX5glutaredoxin 5 | Not recorded | In 1 condition |
| IER3IP1immediate early response 3 interacting protein 1 | Not recorded | In 1 condition |
| KCNN4potassium calcium-activated channel subfamily N member 4 | Not recorded | In 1 condition |
| KIF23kinesin family member 23 | Not recorded | In 1 condition |
| KRT18keratin 18 | Not recorded | In 1 condition |
| LPLlipoprotein lipase | Not recorded | In 1 condition |
| NBASNBAS subunit of NRZ tethering complex | Not recorded | In 1 condition |
| OCLNoccludin | Not recorded | In 1 condition |
| POU1F1POU class 1 homeobox 1 | Not recorded | In 1 condition |
| RINT1RAD50 interactor 1 | Not recorded | In 1 condition |
| SEC23BSEC23 homolog B, COPII component | Not recorded | In 1 condition |
| SKIC3SKI3 subunit of superkiller complex | Not recorded | In 1 condition |
| TBX19T-box transcription factor 19 | Not recorded | In 1 condition |
| TPI1triosephosphate isomerase 1 | Not recorded | In 1 condition |
| TULP3TUB like protein 3 | Not recorded | In 1 condition |
| USP53ubiquitin specific peptidase 53 | Not recorded | In 1 condition |
| VIPAS39VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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