Trait
Migraine
Migraine is a chronic neurological disorder characterized by episodic attacks of headache and associated symptoms.
Summary
- Also called
- Intermittent migraine headaches, Migraine headache, Migraine headaches
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Migraine, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test157 genes linked to Migraine
Changes in these genes cause rare conditions in which Migraine is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AMACRalpha-methylacyl-CoA racemase | Always | In 2 conditions |
| ATP1A2ATPase Na+/K+ transporting subunit alpha 2 | Always | In 1 condition |
| CACNA1Acalcium voltage-gated channel subunit alpha1 A | Always | In 4 conditions |
| CSNK1Dcasein kinase 1 delta | Always | In 1 condition |
| CTSAcathepsin A | Always | In 1 condition |
| JPH1junctophilin 1 | Always | In 1 condition |
| LRRC7leucine rich repeat containing 7 | Always | In 1 condition |
| NOTCH3notch receptor 3 | Always | In 3 conditions |
| PEX11Bperoxisomal biogenesis factor 11 beta | Always | In 1 condition |
| RAB3ARAB3A, member RAS oncogene family | Always | In 1 condition |
| ADA2adenosine deaminase 2 | Very often (80–99%) | In 1 condition |
| APPamyloid beta precursor protein | Very often (80–99%) | In 2 conditions |
| C4Acomplement C4A (Chido/Rodgers blood group) | Very often (80–99%) | In 1 condition |
| CCR1C-C motif chemokine receptor 1 | Very often (80–99%) | In 1 condition |
| CLTRNcollectrin, amino acid transport regulator | Very often (80–99%) | In 1 condition |
| COL5A1collagen type V alpha 1 chain | Very often (80–99%) | In 1 condition |
| ERAP1endoplasmic reticulum aminopeptidase 1 | Very often (80–99%) | In 1 condition |
| FASFas cell surface death receptor | Very often (80–99%) | In 1 condition |
| HLA-Bmajor histocompatibility complex, class I, B | Very often (80–99%) | In 2 conditions |
| IFNGR1interferon gamma receptor 1 | Very often (80–99%) | In 1 condition |
| IL10interleukin 10 | Very often (80–99%) | In 1 condition |
| IL12Ainterleukin 12A | Very often (80–99%) | In 1 condition |
| IL12A-AS1IL12A antisense RNA 1 | Very often (80–99%) | In 1 condition |
| IL23Rinterleukin 23 receptor | Very often (80–99%) | In 1 condition |
| KLRC4killer cell lectin like receptor C4 | Very often (80–99%) | In 1 condition |
| MEFVMEFV innate immunity regulator, pyrin | Very often (80–99%) | In 1 condition |
| MT-CO1mitochondrially encoded cytochrome c oxidase I | Very often (80–99%) | In 2 conditions |
| MT-CO2mitochondrially encoded cytochrome c oxidase II | Very often (80–99%) | In 2 conditions |
| MT-CO3mitochondrially encoded cytochrome c oxidase III | Very often (80–99%) | In 2 conditions |
| MT-ND1mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 | Very often (80–99%) | In 2 conditions |
| MT-ND4mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 | Very often (80–99%) | In 1 condition |
| MT-ND5mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 | Very often (80–99%) | In 2 conditions |
| MT-ND6mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 | Very often (80–99%) | In 2 conditions |
| MT-TFmitochondrially encoded tRNA-Phe (UUU/C) | Very often (80–99%) | In 2 conditions |
| MT-THmitochondrially encoded tRNA-His (CAU/C) | Very often (80–99%) | In 2 conditions |
| MT-TL1mitochondrially encoded tRNA-Leu (UUA/G) 1 | Very often (80–99%) | In 2 conditions |
| MT-TQmitochondrially encoded tRNA-Gln (CAA/G) | Very often (80–99%) | In 2 conditions |
| MT-TS1mitochondrially encoded tRNA-Ser (UCN) 1 | Very often (80–99%) | In 2 conditions |
| MT-TS2mitochondrially encoded tRNA-Ser (AGU/C) 2 | Very often (80–99%) | In 2 conditions |
| MT-TWmitochondrially encoded tRNA-Trp (UGA/G) | Very often (80–99%) | In 2 conditions |
Show 117 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| NLRP3NLR family pyrin domain containing 3 | Very often (80–99%) | In 1 condition |
| SLC6A19solute carrier family 6 member 19 | Very often (80–99%) | In 1 condition |
| STAT4signal transducer and activator of transcription 4 | Very often (80–99%) | In 1 condition |
| TLR4toll like receptor 4 | Very often (80–99%) | In 1 condition |
| UBAC2UBA domain containing 2 | Very often (80–99%) | In 1 condition |
| ACVRL1activin A receptor like type 1 | Often (30–79%) | In 2 conditions |
| ADAMTS3ADAM metallopeptidase with thrombospondin type 1 motif 3 | Often (30–79%) | In 1 condition |
| ADAMTSL1ADAMTS like 1 | Often (30–79%) | In 1 condition |
| AIPAHR interacting HSP90 co-chaperone | Often (30–79%) | In 1 condition |
| ALPK1alpha kinase 1 | Often (30–79%) | In 1 condition |
| ATMATM serine/threonine kinase | Often (30–79%) | In 1 condition |
| BMPR1Abone morphogenetic protein receptor type 1A | Often (30–79%) | In 1 condition |
| BRCA2BRCA2 DNA repair associated | Often (30–79%) | In 1 condition |
| CALRcalreticulin | Often (30–79%) | In 1 condition |
| CHEK2checkpoint kinase 2 | Often (30–79%) | In 1 condition |
| CST3cystatin C | Often (30–79%) | In 1 condition |
| ENGendoglin | Often (30–79%) | In 2 conditions |
| EPCAMepithelial cell adhesion molecule | Often (30–79%) | In 1 condition |
| GATA2GATA binding protein 2 | Often (30–79%) | In 1 condition |
| GDF2growth differentiation factor 2 | Often (30–79%) | In 1 condition |
| GPR101G protein-coupled receptor 101 | Often (30–79%) | In 1 condition |
| GUK1guanylate kinase 1 | Often (30–79%) | In 1 condition |
| IL12Binterleukin 12B | Often (30–79%) | In 1 condition |
| JAK2Janus kinase 2 | Often (30–79%) | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Often (30–79%) | In 1 condition |
| MLH1mutL homolog 1 | Often (30–79%) | In 1 condition |
| MLXMAX dimerization protein MLX | Often (30–79%) | In 1 condition |
| MPLMPL proto-oncogene, thrombopoietin receptor | Often (30–79%) | In 1 condition |
| MRPL39mitochondrial ribosomal protein L39 | Often (30–79%) | In 1 condition |
| MSH2mutS homolog 2 | Often (30–79%) | In 1 condition |
| MSH6mutS homolog 6 | Often (30–79%) | In 1 condition |
| MUTYHmutY DNA glycosylase | Often (30–79%) | In 1 condition |
| MVKmevalonate kinase | Often (30–79%) | In 1 condition |
| NAA60N-alpha-acetyltransferase 60, NatF catalytic subunit | Often (30–79%) | In 1 condition |
| NF1neurofibromin 1 | Often (30–79%) | In 1 condition |
| NPATnuclear protein, coactivator of histone transcription | Often (30–79%) | In 1 condition |
| PGK1phosphoglycerate kinase 1 | Often (30–79%) | In 2 conditions |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Often (30–79%) | In 1 condition |
| PMS1PMS1 homolog 1, mismatch repair system component | Often (30–79%) | In 1 condition |
| PMS2PMS1 homolog 2, mismatch repair system component | Often (30–79%) | In 1 condition |
| POLD1DNA polymerase delta 1, catalytic subunit | Often (30–79%) | In 1 condition |
| POLEDNA polymerase epsilon, catalytic subunit | Often (30–79%) | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Often (30–79%) | In 4 conditions |
| RPS20ribosomal protein S20 | Often (30–79%) | In 1 condition |
| SEMA4Asemaphorin 4A | Often (30–79%) | In 1 condition |
| SH2B3SH2B adaptor protein 3 | Often (30–79%) | In 1 condition |
| SMAD2SMAD family member 2 | Often (30–79%) | In 1 condition |
| SMAD3SMAD family member 3 | Often (30–79%) | In 2 conditions |
| SMAD4SMAD family member 4 | Often (30–79%) | In 1 condition |
| SMARCAL1SNF2 related chromatin remodeling annealing helicase 1 | Often (30–79%) | In 1 condition |
| SMARCB1SWI/SNF related BAF chromatin remodeling complex subunit B1 | Often (30–79%) | In 1 condition |
| SPOPspeckle type BTB/POZ protein | Often (30–79%) | In 1 condition |
| SQORsulfide quinone oxidoreductase | Often (30–79%) | In 1 condition |
| STARD7StAR related lipid transfer domain containing 7 | Often (30–79%) | In 1 condition |
| STIM1stromal interaction molecule 1 | Often (30–79%) | In 1 condition |
| SUFUSUFU negative regulator of hedgehog signaling | Often (30–79%) | In 1 condition |
| TET2tet methylcytosine dioxygenase 2 | Often (30–79%) | In 1 condition |
| TGFBR2transforming growth factor beta receptor 2 | Often (30–79%) | In 1 condition |
| TP53tumor protein p53 | Often (30–79%) | In 1 condition |
| TREX1three prime repair exonuclease 1 | Often (30–79%) | In 2 conditions |
| ZFTAzinc finger translocation associated | Often (30–79%) | In 1 condition |
| ACSF3acyl-CoA synthetase family member 3 | Sometimes (5–29%) | In 1 condition |
| COPB1coat protein complex I subunit beta 1 | Sometimes (5–29%) | In 1 condition |
| CTSHcathepsin H | Sometimes (5–29%) | In 1 condition |
| FGFR2fibroblast growth factor receptor 2 | Sometimes (5–29%) | In 1 condition |
| FGFR3fibroblast growth factor receptor 3 | Sometimes (5–29%) | In 2 conditions |
| FRMD5FERM domain containing 5 | Sometimes (5–29%) | In 1 condition |
| GABRG2gamma-aminobutyric acid type A receptor subunit gamma2 | Sometimes (5–29%) | In 1 condition |
| GRIN2Aglutamate ionotropic receptor NMDA type subunit 2A | Sometimes (5–29%) | In 1 condition |
| HCRThypocretin neuropeptide precursor | Sometimes (5–29%) | In 1 condition |
| HLA-DQB1major histocompatibility complex, class II, DQ beta 1 | Sometimes (5–29%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Sometimes (5–29%) | In 1 condition |
| JAG1jagged canonical Notch ligand 1 | Sometimes (5–29%) | In 1 condition |
| KCNA1potassium voltage-gated channel subfamily A member 1 | Sometimes (5–29%) | In 1 condition |
| KCNJ10potassium inwardly rectifying channel subfamily J member 10 | Sometimes (5–29%) | In 1 condition |
| MOGmyelin oligodendrocyte glycoprotein | Sometimes (5–29%) | In 1 condition |
| MYD88MYD88 innate immune signal transduction adaptor | Sometimes (5–29%) | In 1 condition |
| MYORGmyogenesis regulating glycosidase | Sometimes (5–29%) | In 1 condition |
| NDPnorrin cystine knot growth factor NDP | Sometimes (5–29%) | In 1 condition |
| NFIXnuclear factor I X | Sometimes (5–29%) | In 1 condition |
| P2RY11purinergic receptor P2Y11 | Sometimes (5–29%) | In 1 condition |
| PDGFBplatelet derived growth factor subunit B | Sometimes (5–29%) | In 1 condition |
| PDGFRBplatelet derived growth factor receptor beta | Sometimes (5–29%) | In 1 condition |
| PLAAT3phospholipase A and acyltransferase 3 | Sometimes (5–29%) | In 1 condition |
| PRORPprotein only RNase P catalytic subunit | Sometimes (5–29%) | In 1 condition |
| PRRT2proline rich transmembrane protein 2 | Sometimes (5–29%) | In 2 conditions |
| RNASEH1ribonuclease H1 | Sometimes (5–29%) | In 1 condition |
| RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2B | Sometimes (5–29%) | In 2 conditions |
| SH2B1SH2B adaptor protein 1 | Sometimes (5–29%) | In 1 condition |
| SLC1A3solute carrier family 1 member 3 | Sometimes (5–29%) | In 2 conditions |
| SLC2A1solute carrier family 2 member 1 | Sometimes (5–29%) | In 2 conditions |
| SRPX2sushi repeat containing protein X-linked 2 | Sometimes (5–29%) | In 1 condition |
| TNFRSF1ATNF receptor superfamily member 1A | Sometimes (5–29%) | In 1 condition |
| TNFSF4TNF superfamily member 4 | Sometimes (5–29%) | In 1 condition |
| TWIST1twist family bHLH transcription factor 1 | Sometimes (5–29%) | In 1 condition |
| TWNKtwinkle mtDNA helicase | Sometimes (5–29%) | In 4 conditions |
| ZNF365zinc finger protein 365 | Sometimes (5–29%) | In 1 condition |
| DNM1Ldynamin 1L | Rarely (1–4%) | In 1 condition |
| GP1BAglycoprotein Ib platelet subunit alpha | Rarely (1–4%) | In 1 condition |
| GP1BBglycoprotein Ib platelet subunit beta | Rarely (1–4%) | In 1 condition |
| GP9glycoprotein IX platelet | Rarely (1–4%) | In 1 condition |
| LGI1leucine rich glioma inactivated 1 | Rarely (1–4%) | In 1 condition |
| MICAL1microtubule associated monooxygenase, calponin and LIM domain containing 1 | Rarely (1–4%) | In 1 condition |
| NOP56NOP56 ribonucleoprotein | Rarely (1–4%) | In 1 condition |
| OPA1OPA1 mitochondrial dynamin like GTPase | Rarely (1–4%) | In 2 conditions |
| POLG2DNA polymerase gamma 2, accessory subunit | Rarely (1–4%) | In 1 condition |
| PPIBpeptidylprolyl isomerase B | Rarely (1–4%) | In 1 condition |
| RELNreelin | Rarely (1–4%) | In 1 condition |
| SLC25A4solute carrier family 25 member 4 | Rarely (1–4%) | In 1 condition |
| ANO1anoctamin 1 | Not recorded | In 1 condition |
| COL4A1collagen type IV alpha 1 chain | Not recorded | In 1 condition |
| HTR1A5-hydroxytryptamine receptor 1A | Not recorded | In 1 condition |
| MT-CYBmitochondrially encoded cytochrome b | Not recorded | In 1 condition |
| MT-TCmitochondrially encoded tRNA-Cys (UGU/C) | Not recorded | In 1 condition |
| MT-TKmitochondrially encoded tRNA-Lys (AAA/G) | Not recorded | In 1 condition |
| MT-TL2mitochondrially encoded tRNA-Leu (CUN) 2 | Not recorded | In 1 condition |
| MT-TVmitochondrially encoded tRNA-Val (GUN) | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks