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Trait
Breast cancer
Clinical name: Breast carcinoma
The presence of a carcinoma of the breast.
Summary
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This page as data
Add .json to the page's address, or ask for application/json, to read it as JSON.
library(jsonlite)
url <- "https://dantelabs.com/traits/breast-carcinoma.json"
page <- fromJSON(url)
page$trait$nameBreast cancerHP:0003002
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Read the genes linked to Breast cancer, and the rest of your genome, with one test.
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Get my Genome Test67 genes linked to Breast cancer
Changes in these genes cause rare conditions in which Breast cancer is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| PTENphosphatase and tensin homolog | Very often (80–99%) | In 3 conditions |
| AKT1AKT serine/threonine kinase 1 | Often (30–79%) | In 3 conditions |
| ATMATM serine/threonine kinase | Often (30–79%) | In 2 conditions |
| BARD1BRCA1 associated RING domain 1 | Often (30–79%) | In 2 conditions |
| BRCA1BRCA1 DNA repair associated | Often (30–79%) | In 5 conditions |
| BRCA2BRCA2 DNA repair associated | Often (30–79%) | In 4 conditions |
| BRIP1BRCA1 interacting DNA helicase 1 | Often (30–79%) | In 2 conditions |
| CDKN2Acyclin dependent kinase inhibitor 2A | Often (30–79%) | In 2 conditions |
| CHEK2checkpoint kinase 2 | Often (30–79%) | In 3 conditions |
| MDM2MDM2 proto-oncogene | Often (30–79%) | In 1 condition |
| MRE11MRE11 double strand break repair nuclease | Often (30–79%) | In 1 condition |
| NBNnibrin | Often (30–79%) | In 1 condition |
| NTHL1nth like DNA glycosylase 1 | Often (30–79%) | In 2 conditions |
| PALB2partner and localizer of BRCA2 | Often (30–79%) | In 3 conditions |
| RAD50RAD50 double strand break repair protein | Often (30–79%) | In 1 condition |
| RAD51RAD51 recombinase | Often (30–79%) | In 2 conditions |
| RAD51CRAD51 paralog C | Often (30–79%) | In 2 conditions |
| RAD51DRAD51 paralog D | Often (30–79%) | In 1 condition |
| TP53tumor protein p53 | Often (30–79%) | In 5 conditions |
| AAGABalpha and gamma adaptin binding protein | Sometimes (5–29%) | In 1 condition |
| APCAPC regulator of Wnt signaling pathway | Sometimes (5–29%) | In 2 conditions |
| AXIN2axin 2 | Sometimes (5–29%) | In 1 condition |
| COL14A1collagen type XIV alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| EPCAMepithelial cell adhesion molecule | Sometimes (5–29%) | In 1 condition |
| IDH1isocitrate dehydrogenase (NADP(+)) 1 | Sometimes (5–29%) | In 1 condition |
| IDH2isocitrate dehydrogenase (NADP(+)) 2 | Sometimes (5–29%) | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Sometimes (5–29%) | In 3 conditions |
| MLH1mutL homolog 1 | Sometimes (5–29%) | In 2 conditions |
| MSH2mutS homolog 2 | Sometimes (5–29%) | In 2 conditions |
| MSH6mutS homolog 6 | Sometimes (5–29%) | In 1 condition |
| PALLDpalladin, cytoskeletal associated protein | Sometimes (5–29%) | In 1 condition |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Sometimes (5–29%) | In 4 conditions |
| PMS1PMS1 homolog 1, mismatch repair system component | Sometimes (5–29%) | In 1 condition |
| PMS2PMS1 homolog 2, mismatch repair system component | Sometimes (5–29%) | In 1 condition |
| POLD1DNA polymerase delta 1, catalytic subunit | Sometimes (5–29%) | In 1 condition |
| POLEDNA polymerase epsilon, catalytic subunit | Sometimes (5–29%) | In 1 condition |
| RABL3RAB, member of RAS oncogene family like 3 | Sometimes (5–29%) | In 1 condition |
| SLC6A17solute carrier family 6 member 17 | Sometimes (5–29%) | In 1 condition |
| SMAD4SMAD family member 4 | Sometimes (5–29%) | In 1 condition |
| STK11serine/threonine kinase 11 | Sometimes (5–29%) | In 2 conditions |
Show 27 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| TGFBR2transforming growth factor beta receptor 2 | Sometimes (5–29%) | In 1 condition |
| WRNWRN RecQ like helicase | Sometimes (5–29%) | In 1 condition |
| ATRATR checkpoint kinase | Rarely (1–4%) | In 1 condition |
| GNASGNAS complex locus | Rarely (1–4%) | In 1 condition |
| MEFVMEFV innate immunity regulator, pyrin | Rarely (1–4%) | In 1 condition |
| NF1neurofibromin 1 | Rarely (1–4%) | In 2 conditions |
| PTPN6protein tyrosine phosphatase non-receptor type 6 | Rarely (1–4%) | In 1 condition |
| RNF43ring finger protein 43 | Rarely (1–4%) | In 1 condition |
| CASP8caspase 8 | Not recorded | In 1 condition |
| CDH1cadherin 1 | Not recorded | In 2 conditions |
| CTNNB1catenin beta 1 | Not recorded | In 1 condition |
| ERBB2erb-b2 receptor tyrosine kinase 2 | Not recorded | In 1 condition |
| ESR1estrogen receptor 1 | Not recorded | In 1 condition |
| FGFR2fibroblast growth factor receptor 2 | Not recorded | In 1 condition |
| HMMRhyaluronan mediated motility receptor | Not recorded | In 1 condition |
| KLLNkillin, p53 regulated DNA replication inhibitor | Not recorded | In 1 condition |
| NQO2N-ribosyldihydronicotinamide:quinone dehydrogenase 2 | Not recorded | In 1 condition |
| OPCMLopioid binding protein/cell adhesion molecule like | Not recorded | In 1 condition |
| PHB1prohibitin 1 | Not recorded | In 1 condition |
| PPM1Dprotein phosphatase, Mg2+/Mn2+ dependent 1D | Not recorded | In 1 condition |
| PRKNparkin RBR E3 ubiquitin protein ligase | Not recorded | In 1 condition |
| RAD54LRAD54 like | Not recorded | In 1 condition |
| RB1CC1RB1 inducible coiled-coil 1 | Not recorded | In 1 condition |
| SEC23BSEC23 homolog B, COPII component | Not recorded | In 1 condition |
| SLC67A1solute carrier family 67 member 1 | Not recorded | In 1 condition |
| TWIST1twist family bHLH transcription factor 1 | Not recorded | In 1 condition |
| XRCC3X-ray repair cross complementing 3 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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