Trait
Myelofibrosis
Replacement of bone marrow by fibrous tissue.
Summary
Reference genomeGRCh38hg38
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Get my Genome Test16 genes linked to Myelofibrosis
Changes in these genes cause rare conditions in which Myelofibrosis is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CALRcalreticulin | Always | In 2 conditions |
| GFI1Bgrowth factor independent 1B transcriptional repressor | Always | In 1 condition |
| JAK2Janus kinase 2 | Always | In 3 conditions |
| MPIG6Bmegakaryocyte and platelet inhibitory receptor G6b | Always | In 1 condition |
| MPLMPL proto-oncogene, thrombopoietin receptor | Always | In 2 conditions |
| SH2B3SH2B adaptor protein 3 | Always | In 2 conditions |
| TBXAS1thromboxane A synthase 1 | Always | In 1 condition |
| RBSNrabenosyn, RAB effector | Often (30–79%) | In 1 condition |
| HPGD15-hydroxyprostaglandin dehydrogenase | Sometimes (5–29%) | In 1 condition |
| SHOC2SHOC2 leucine rich repeat scaffold protein | Sometimes (5–29%) | In 1 condition |
| SLCO2A1solute carrier organic anion transporter family member 2A1 | Sometimes (5–29%) | In 1 condition |
| TET2tet methylcytosine dioxygenase 2 | Sometimes (5–29%) | In 1 condition |
| TLR8toll like receptor 8 | Sometimes (5–29%) | In 1 condition |
| TP53tumor protein p53 | Sometimes (5–29%) | In 1 condition |
| NBEAL2neurobeachin like 2 | Not recorded | In 1 condition |
| SRCSRC proto-oncogene, non-receptor tyrosine kinase | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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