Trait
Joint swelling
Summary
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test53 genes linked to Joint swelling
Changes in these genes cause rare conditions in which Joint swelling is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ASAH1N-acylsphingosine amidohydrolase 1 | Always | In 2 conditions |
| GNB2G protein subunit beta 2 | Always | In 1 condition |
| IL1RNinterleukin 1 receptor antagonist | Always | In 1 condition |
| LPIN2lipin 2 | Always | In 1 condition |
| OTULINOTU deubiquitinase with linear linkage specificity | Always | In 1 condition |
| AIPAHR interacting HSP90 co-chaperone | Very often (80–99%) | In 1 condition |
| ANKHANKH inorganic pyrophosphate transport regulator | Very often (80–99%) | In 1 condition |
| ATP7BATPase copper transporting beta | Very often (80–99%) | In 1 condition |
| CCN2cellular communication network factor 2 | Very often (80–99%) | In 1 condition |
| CCN6cellular communication network factor 6 | Very often (80–99%) | In 2 conditions |
| FGAfibrinogen alpha chain | Very often (80–99%) | In 1 condition |
| FGBfibrinogen beta chain | Very often (80–99%) | In 1 condition |
| FGGfibrinogen gamma chain | Very often (80–99%) | In 1 condition |
| GPR101G protein-coupled receptor 101 | Very often (80–99%) | In 1 condition |
| HGDhomogentisate 1,2-dioxygenase | Very often (80–99%) | In 1 condition |
| HLA-Bmajor histocompatibility complex, class I, B | Very often (80–99%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Very often (80–99%) | In 2 conditions |
| IL6interleukin 6 | Very often (80–99%) | In 1 condition |
| LACC1laccase domain multifunctional purine nucleosidase 1 | Very often (80–99%) | In 1 condition |
| MEFVMEFV innate immunity regulator, pyrin | Very often (80–99%) | In 1 condition |
| MIFmacrophage migration inhibitory factor | Very often (80–99%) | In 1 condition |
| NOD2nucleotide binding oligomerization domain containing 2 | Very often (80–99%) | In 2 conditions |
| TNFRSF11BTNF receptor superfamily member 11b | Very often (80–99%) | In 1 condition |
| TNFRSF1ATNF receptor superfamily member 1A | Very often (80–99%) | In 1 condition |
| ACP5acid phosphatase 5, tartrate resistant | Often (30–79%) | In 1 condition |
| ANKRD55ankyrin repeat domain 55 | Often (30–79%) | In 1 condition |
| BTNL2butyrophilin like 2 | Often (30–79%) | In 1 condition |
| CD247CD247 molecule | Often (30–79%) | In 1 condition |
| CHEK2checkpoint kinase 2 | Often (30–79%) | In 1 condition |
| DDR2discoidin domain receptor tyrosine kinase 2 | Often (30–79%) | In 1 condition |
| F8coagulation factor VIII | Often (30–79%) | In 2 conditions |
| HPGD15-hydroxyprostaglandin dehydrogenase | Often (30–79%) | In 2 conditions |
| IL2RAinterleukin 2 receptor subunit alpha | Often (30–79%) | In 1 condition |
| IL2RBinterleukin 2 receptor subunit beta | Often (30–79%) | In 1 condition |
| OCRLOCRL inositol polyphosphate-5-phosphatase | Often (30–79%) | In 1 condition |
| PTPN2protein tyrosine phosphatase non-receptor type 2 | Often (30–79%) | In 1 condition |
| PTPN22protein tyrosine phosphatase non-receptor type 22 | Often (30–79%) | In 1 condition |
| RB1RB transcriptional corepressor 1 | Often (30–79%) | In 1 condition |
| SLCO2A1solute carrier organic anion transporter family member 2A1 | Often (30–79%) | In 1 condition |
| STAT4signal transducer and activator of transcription 4 | Often (30–79%) | In 1 condition |
Show 13 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| TP53tumor protein p53 | Often (30–79%) | In 1 condition |
| TRAPPC2trafficking protein particle complex subunit 2 | Often (30–79%) | In 1 condition |
| BMP6bone morphogenetic protein 6 | Sometimes (5–29%) | In 1 condition |
| COL1A1collagen type I alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| COL5A1collagen type V alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| COL5A2collagen type V alpha 2 chain | Sometimes (5–29%) | In 1 condition |
| HFEhomeostatic iron regulator | Sometimes (5–29%) | In 1 condition |
| SYKspleen associated tyrosine kinase | Sometimes (5–29%) | In 1 condition |
| CD244CD244 molecule | Not recorded | In 1 condition |
| CIITAclass II major histocompatibility complex transactivator | Not recorded | In 1 condition |
| IL10interleukin 10 | Not recorded | In 1 condition |
| NFKBIL1NFKB inhibitor like 1 | Not recorded | In 1 condition |
| SLC22A4solute carrier family 22 member 4 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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