Trait
Colorectal polyposis
Multiple abnormal growths that arise from the lining of the large intestine (colon or rectum) and protrude into the intestinal lumen.
Summary
- Also called
- Colorectal polyps
Reference genomeGRCh38hg38
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Get my Genome Test17 genes linked to Colorectal polyposis
Changes in these genes cause rare conditions in which Colorectal polyposis is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| APCAPC regulator of Wnt signaling pathway | Very often (80–99%) | In 3 conditions |
| MSH3mutS homolog 3 | Very often (80–99%) | In 1 condition |
| MUTYHmutY DNA glycosylase | Very often (80–99%) | In 1 condition |
| PTENphosphatase and tensin homolog | Very often (80–99%) | In 1 condition |
| RNF43ring finger protein 43 | Very often (80–99%) | In 1 condition |
| ALKALK receptor tyrosine kinase | Often (30–79%) | In 1 condition |
| AXIN2axin 2 | Often (30–79%) | In 1 condition |
| BMPR1Abone morphogenetic protein receptor type 1A | Often (30–79%) | In 1 condition |
| DICER1dicer 1, ribonuclease III | Often (30–79%) | In 1 condition |
| GREM1gremlin 1, DAN family BMP antagonist | Often (30–79%) | In 1 condition |
| KEAP1kelch like ECH associated protein 1 | Often (30–79%) | In 1 condition |
| POLD1DNA polymerase delta 1, catalytic subunit | Often (30–79%) | In 2 conditions |
| POLEDNA polymerase epsilon, catalytic subunit | Often (30–79%) | In 2 conditions |
| CDKN2Acyclin dependent kinase inhibitor 2A | Sometimes (5–29%) | In 1 condition |
| CHEK2checkpoint kinase 2 | Sometimes (5–29%) | In 1 condition |
| MDM2MDM2 proto-oncogene | Sometimes (5–29%) | In 1 condition |
| TP53tumor protein p53 | Sometimes (5–29%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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