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Trait
Ovarian cancer
Clinical name: Ovarian neoplasm
A tumor (abnormal growth of tissue) of the ovary.
Summary
- Also called
- Ovarian tumor, Neoplasm of the ovaries, Neoplasm of the ovary, Ovarian tumour
Ovarian cancerHP:0100615
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Read the genes linked to Ovarian cancer, and the rest of your genome, with one test.
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Get my Genome Test49 genes linked to Ovarian cancer
Changes in these genes cause rare conditions in which Ovarian cancer is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| MLH1mutL homolog 1 | Always | In 2 conditions |
| MSH2mutS homolog 2 | Always | In 2 conditions |
| ATMATM serine/threonine kinase | Very often (80–99%) | In 2 conditions |
| BARD1BRCA1 associated RING domain 1 | Very often (80–99%) | In 1 condition |
| BRCA1BRCA1 DNA repair associated | Very often (80–99%) | In 3 conditions |
| BRCA2BRCA2 DNA repair associated | Very often (80–99%) | In 3 conditions |
| BRIP1BRCA1 interacting DNA helicase 1 | Very often (80–99%) | In 1 condition |
| CHEK2checkpoint kinase 2 | Very often (80–99%) | In 3 conditions |
| MRE11MRE11 double strand break repair nuclease | Very often (80–99%) | In 1 condition |
| NBNnibrin | Very often (80–99%) | In 1 condition |
| PALB2partner and localizer of BRCA2 | Very often (80–99%) | In 1 condition |
| PTENphosphatase and tensin homolog | Very often (80–99%) | In 3 conditions |
| RAD50RAD50 double strand break repair protein | Very often (80–99%) | In 1 condition |
| RAD51RAD51 recombinase | Very often (80–99%) | In 1 condition |
| RAD51CRAD51 paralog C | Very often (80–99%) | In 1 condition |
| RAD51DRAD51 paralog D | Very often (80–99%) | In 1 condition |
| TP53tumor protein p53 | Very often (80–99%) | In 2 conditions |
| DICER1dicer 1, ribonuclease III | Often (30–79%) | In 1 condition |
| KEAP1kelch like ECH associated protein 1 | Often (30–79%) | In 1 condition |
| LMNAlamin A/C | Often (30–79%) | In 1 condition |
| AKT1AKT serine/threonine kinase 1 | Sometimes (5–29%) | In 1 condition |
| EPCAMepithelial cell adhesion molecule | Sometimes (5–29%) | In 1 condition |
| EWSR1EWS RNA binding protein 1 | Sometimes (5–29%) | In 1 condition |
| FLI1Fli-1 proto-oncogene, ETS transcription factor | Sometimes (5–29%) | In 1 condition |
| FOXE1forkhead box E1 | Sometimes (5–29%) | In 1 condition |
| IDH1isocitrate dehydrogenase (NADP(+)) 1 | Sometimes (5–29%) | In 1 condition |
| IDH2isocitrate dehydrogenase (NADP(+)) 2 | Sometimes (5–29%) | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Sometimes (5–29%) | In 1 condition |
| MSH6mutS homolog 6 | Sometimes (5–29%) | In 2 conditions |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Sometimes (5–29%) | In 1 condition |
| PMS1PMS1 homolog 1, mismatch repair system component | Sometimes (5–29%) | In 1 condition |
| PMS2PMS1 homolog 2, mismatch repair system component | Sometimes (5–29%) | In 2 conditions |
| STAG3STAG3 cohesin complex component | Sometimes (5–29%) | In 1 condition |
| TGFBR2transforming growth factor beta receptor 2 | Sometimes (5–29%) | In 1 condition |
| WNT10AWnt family member 10A | Sometimes (5–29%) | In 1 condition |
| WRNWRN RecQ like helicase | Sometimes (5–29%) | In 1 condition |
| WT1WT1 transcription factor | Sometimes (5–29%) | In 1 condition |
| CDKN2Acyclin dependent kinase inhibitor 2A | Rarely (1–4%) | In 1 condition |
| MDM2MDM2 proto-oncogene | Rarely (1–4%) | In 1 condition |
| RNF43ring finger protein 43 | Rarely (1–4%) | In 1 condition |
Show 9 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| SPRED1sprouty related EVH1 domain containing 1 | Rarely (1–4%) | In 1 condition |
| ZFTAzinc finger translocation associated | Rarely (1–4%) | In 1 condition |
| BMPR1Abone morphogenetic protein receptor type 1A | Not recorded | In 1 condition |
| MUTYHmutY DNA glycosylase | Not recorded | In 1 condition |
| NPATnuclear protein, coactivator of histone transcription | Not recorded | In 1 condition |
| POLD1DNA polymerase delta 1, catalytic subunit | Not recorded | In 1 condition |
| POLEDNA polymerase epsilon, catalytic subunit | Not recorded | In 1 condition |
| RPS20ribosomal protein S20 | Not recorded | In 1 condition |
| SEMA4Asemaphorin 4A | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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