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Gene

MET

MET proto-oncogene, receptor tyrosine kinase

Summary

Cytogenetic location
7q31.2
Coordinates
Chromosome 7: 116,672,196–116,798,377 (GRCh38)
Exons
21 exons across 126.2 kb
Protein
1,390 amino acids
Also known as
HGFR, RCCP2, DFNB97
MANE Select transcript
ENST00000397752.8NM_000245.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Kidney Cancer

    • Primary or metastatic malignant neoplasm involving the kidney.

      • ClinGen rates the link definitive
      • 6 GenCC submitters rate it definitive or strong

  • Urinary and Renal System Tumour

    • Urinary System Neoplasm

      A benign or malignant, primary or metastatic neoplasm involving the urinary system.

      • ClinGen rates the link definitive
      • 6 GenCC submitters rate it definitive or strong

Broader groupings

  • Hearing Loss and Deafness

    • Nonsyndromic Genetic Hearing Loss

      One of 97 genes linked to it

      Inherited hearing loss without other medical features, including the common recessive forms caused by GJB2, OTOF, SLC26A4, STRC and many other genes, as well as dominant, X-linked and mitochondrial forms.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Knowing the genetic cause can guide hearing support and cochlear implant decisions, gene-therapy trial eligibility (for example OTOF) and family counselling.

How MET is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 7, with a bracket where MET sits. MET and 6 genes near it on chromosome 7, from 116,235,287 to 117,235,286.Chromosome 77q31.2p22.3p22.2p22.1p21.3p21.2p21.1p15.3p15.2p15.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.21q11.22q11.23q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q31.1q31.2q31.31q31.32q31.33q32.1q32.2q32.3q33q34q35q36.1q36.2q36.3116.4 Mb116.6 Mb116.8 Mb117 Mb117.2 MbTES: 116,210,493–116,258,919, forward strandTESCAV2: 116,287,380–116,508,545, forward strandCAV2CAV1: 116,524,985–116,561,179, forward strandCAV1MET: 116,672,196–116,798,377, forward strandMETCAPZA2: 116,811,070–116,947,923, forward strandCAPZA2ST7: 116,952,980–117,230,812, forward strandST7: 116,954,391–117,119,719, forward strandDiagram of MET: 21 exons on the forward strand of chromosome 7Exon 16: 1 known disease-causing siteExon 17: 1 known disease-causing siteExon 1: 116,672,196–116,672,577, 382 basesExon 2: 116,699,071–116,700,284, 1,214 basesExon 3: 116,731,668–116,731,859, 192 basesExon 4: 116,739,950–116,740,084, 135 basesExon 5: 116,740,852–116,741,025, 174 basesExon 6: 116,755,355–116,755,515, 161 basesExon 7: 116,757,437–116,757,539, 103 basesExon 8: 116,757,638–116,757,774, 137 basesExon 9: 116,758,459–116,758,620, 162 basesExon 10: 116,759,391–116,759,490, 100 basesExon 11: 116,763,050–116,763,268, 219 basesExon 12: 116,769,645–116,769,791, 147 basesExon 13: 116,771,498–116,771,654, 157 basesExon 14: 116,771,849–116,771,989, 141 basesExon 15: 116,774,881–116,775,111, 231 basesExon 16: 116,777,389–116,777,469, 81 basesExon 17: 116,778,776–116,778,957, 182 basesExon 18: 116,781,988–116,782,097, 110 basesExon 19: 116,783,304–116,783,469, 166 basesExon 20: 116,795,655–116,795,791, 137 basesExon 21: 116,795,887–116,798,377, 2,491 bases1215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.8 kb of the gene's 126.2 kb; 4,173 of those bases code for the protein.

How a genome test reads MET

2

positions in MET where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 126.2 kb of MET, introns included, not only the 6.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). MET gene: MET proto-oncogene, receptor tyrosine kinase. Retrieved 16 October 2026, from https://dantelabs.com/genes/met

Vancouver

Dante Labs. MET gene: MET proto-oncogene, receptor tyrosine kinase [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/met

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