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Trait
Blood spots
Clinical name: Purpura
Purpura (from Latin: purpura, meaning purple) is the appearance of red or purple discolorations on the skin that do not blanch on applying pressure. They are caused by bleeding underneath the skin. This term refers to an abnormally increased susceptibility to developing purpura. Purpura are larger than petechiae.
Summary
- Also called
- Red or purple spots on the skin
Blood spotsHP:0000979
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Read the genes linked to Blood spots, and the rest of your genome, with one test.
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Get my Genome Test81 genes linked to Blood spots
Changes in these genes cause rare conditions in which Blood spots is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CD81CD81 molecule | Always | In 1 condition |
| DNM1Ldynamin 1L | Always | In 1 condition |
| FYB1FYN binding protein 1 | Always | In 1 condition |
| HCKHCK proto-oncogene, Src family tyrosine kinase | Always | In 1 condition |
| LYNLYN proto-oncogene, Src family tyrosine kinase | Always | In 1 condition |
| PROS1protein S | Always | In 3 conditions |
| RUNX1RUNX family transcription factor 1 | Always | In 1 condition |
| TOP2BDNA topoisomerase II beta | Always | In 1 condition |
| ORAI1ORAI calcium release-activated calcium modulator 1 | Very often (80–99%) | In 1 condition |
| STIM1stromal interaction molecule 1 | Very often (80–99%) | In 1 condition |
| ADA2adenosine deaminase 2 | Often (30–79%) | In 1 condition |
| BCORBCL6 corepressor | Often (30–79%) | In 1 condition |
| CD109CD109 molecule | Often (30–79%) | In 1 condition |
| FCGR2CFc gamma receptor IIc (gene/pseudogene) | Often (30–79%) | In 1 condition |
| FIP1L1factor interacting with PAPOLA and CPSF1 | Often (30–79%) | In 1 condition |
| GNA14G protein subunit alpha 14 | Often (30–79%) | In 2 conditions |
| GP1BAglycoprotein Ib platelet subunit alpha | Often (30–79%) | In 2 conditions |
| GP1BBglycoprotein Ib platelet subunit beta | Often (30–79%) | In 3 conditions |
| IRF2BP2interferon regulatory factor 2 binding protein 2 | Often (30–79%) | In 1 condition |
| ITGA2integrin subunit alpha 2 | Often (30–79%) | In 1 condition |
| ITGA2Bintegrin subunit alpha 2b | Often (30–79%) | In 3 conditions |
| ITGB3integrin subunit beta 3 | Often (30–79%) | In 2 conditions |
| NABP1nucleic acid binding protein 1 | Often (30–79%) | In 1 condition |
| NPM1nucleophosmin 1 | Often (30–79%) | In 1 condition |
| NUMA1nuclear mitotic apparatus protein 1 | Often (30–79%) | In 1 condition |
| PMLPML nuclear body scaffold | Often (30–79%) | In 1 condition |
| PRF1perforin 1 | Often (30–79%) | In 1 condition |
| PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha | Often (30–79%) | In 1 condition |
| PROCprotein C, inactivator of coagulation factors Va and VIIIa | Often (30–79%) | In 2 conditions |
| RARAretinoic acid receptor alpha | Often (30–79%) | In 1 condition |
| STAT3signal transducer and activator of transcription 3 | Often (30–79%) | In 1 condition |
| STAT5Bsignal transducer and activator of transcription 5B | Often (30–79%) | In 1 condition |
| STX11syntaxin 11 | Often (30–79%) | In 1 condition |
| STXBP2syntaxin binding protein 2 | Often (30–79%) | In 1 condition |
| TBL1XR1TBL1X/Y related 1 | Often (30–79%) | In 1 condition |
| UNC13Dunc-13 homolog D | Often (30–79%) | In 1 condition |
| WASWASP actin nucleation promoting factor | Often (30–79%) | In 2 conditions |
| ZBTB16zinc finger and BTB domain containing 16 | Often (30–79%) | In 1 condition |
| ARL6IP6ARF like GTPase 6 interacting protein 6 | Sometimes (5–29%) | In 1 condition |
| ARVCFARVCF delta catenin family member | Sometimes (5–29%) | In 1 condition |
Show 41 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| ATRXATRX chromatin remodeler | Sometimes (5–29%) | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Sometimes (5–29%) | In 1 condition |
| CALRcalreticulin | Sometimes (5–29%) | In 2 conditions |
| CDH23cadherin related 23 | Sometimes (5–29%) | In 1 condition |
| COMTcatechol-O-methyltransferase | Sometimes (5–29%) | In 1 condition |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Sometimes (5–29%) | In 1 condition |
| GNA11G protein subunit alpha 11 | Sometimes (5–29%) | In 1 condition |
| HIRAhistone cell cycle regulator | Sometimes (5–29%) | In 1 condition |
| HLA-DPA1major histocompatibility complex, class II, DP alpha 1 | Sometimes (5–29%) | In 1 condition |
| HLA-DPB1major histocompatibility complex, class II, DP beta 1 | Sometimes (5–29%) | In 1 condition |
| JAK2Janus kinase 2 | Sometimes (5–29%) | In 2 conditions |
| JMJD1Cjumonji domain containing 1C | Sometimes (5–29%) | In 1 condition |
| MPLMPL proto-oncogene, thrombopoietin receptor | Sometimes (5–29%) | In 2 conditions |
| MVKmevalonate kinase | Sometimes (5–29%) | In 1 condition |
| MYD88MYD88 innate immune signal transduction adaptor | Sometimes (5–29%) | In 1 condition |
| NLRP3NLR family pyrin domain containing 3 | Sometimes (5–29%) | In 1 condition |
| NR3C1nuclear receptor subfamily 3 group C member 1 | Sometimes (5–29%) | In 1 condition |
| PRTN3proteinase 3 | Sometimes (5–29%) | In 1 condition |
| PTPN22protein tyrosine phosphatase non-receptor type 22 | Sometimes (5–29%) | In 1 condition |
| RREB1ras responsive element binding protein 1 | Sometimes (5–29%) | In 1 condition |
| SEC24CSEC24 homolog C, COPII component | Sometimes (5–29%) | In 1 condition |
| TBX1T-box transcription factor 1 | Sometimes (5–29%) | In 1 condition |
| TET2tet methylcytosine dioxygenase 2 | Sometimes (5–29%) | In 1 condition |
| TP53tumor protein p53 | Sometimes (5–29%) | In 1 condition |
| UFD1ubiquitin recognition factor in ER associated degradation 1 | Sometimes (5–29%) | In 1 condition |
| USP48ubiquitin specific peptidase 48 | Sometimes (5–29%) | In 1 condition |
| USP8ubiquitin specific peptidase 8 | Sometimes (5–29%) | In 2 conditions |
| F8coagulation factor VIII | Rarely (1–4%) | In 1 condition |
| ACP5acid phosphatase 5, tartrate resistant | Not recorded | In 1 condition |
| AIPAHR interacting HSP90 co-chaperone | Not recorded | In 1 condition |
| C2complement C2 | Not recorded | In 1 condition |
| C4Acomplement C4A (Chido/Rodgers blood group) | Not recorded | In 1 condition |
| CFHcomplement factor H | Not recorded | In 1 condition |
| CFHR1complement factor H related 1 | Not recorded | In 1 condition |
| CFHR3complement factor H related 3 | Not recorded | In 1 condition |
| GBA1glucosylceramidase beta 1 | Not recorded | In 1 condition |
| GP9glycoprotein IX platelet | Not recorded | In 1 condition |
| HOXA11homeobox A11 | Not recorded | In 1 condition |
| SH2B3SH2B adaptor protein 3 | Not recorded | In 1 condition |
| TFR2transferrin receptor 2 | Not recorded | In 1 condition |
| TREX1three prime repair exonuclease 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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