Trait
Elevated white blood count
Clinical name: Increased total leukocyte count
An abnormal increase in the number of leukocytes in the blood.
Summary
- Also called
- High white blood count, Increased blood leukocyte number, Leukocytosis
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Elevated white blood count, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test110 genes linked to Elevated white blood count
Changes in these genes cause rare conditions in which Elevated white blood count is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ARPC5actin related protein 2/3 complex subunit 5 | Always | In 1 condition |
| DCLRE1CDNA cross-link repair 1C | Always | In 2 conditions |
| IFNGinterferon gamma | Always | In 1 condition |
| IKZF2IKAROS family zinc finger 2 | Always | In 1 condition |
| IL27RAinterleukin 27 receptor subunit alpha | Always | In 1 condition |
| IL36RNinterleukin 36 receptor antagonist | Always | In 2 conditions |
| IL37interleukin 37 | Always | In 1 condition |
| ITGB2integrin subunit beta 2 | Always | In 1 condition |
| LACC1laccase domain multifunctional purine nucleosidase 1 | Always | In 1 condition |
| LYNLYN proto-oncogene, Src family tyrosine kinase | Always | In 1 condition |
| MICU1mitochondrial calcium uptake 1 | Always | In 1 condition |
| MVKmevalonate kinase | Always | In 2 conditions |
| NBNnibrin | Always | In 1 condition |
| NLRP12NLR family pyrin domain containing 12 | Always | In 1 condition |
| NLRP3NLR family pyrin domain containing 3 | Always | In 4 conditions |
| OAS12'-5'-oligoadenylate synthetase 1 | Always | In 1 condition |
| OSTM1osteoclastogenesis associated transmembrane protein 1 | Always | In 1 condition |
| OTULINOTU deubiquitinase with linear linkage specificity | Always | In 2 conditions |
| PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta | Always | In 1 condition |
| RAC2Rac family small GTPase 2 | Always | In 2 conditions |
| RAG1recombination activating 1 | Always | In 2 conditions |
| RAG2recombination activating 2 | Always | In 2 conditions |
| RELREL proto-oncogene, NF-kB subunit | Always | In 1 condition |
| SHARPINSHANK associated RH domain interactor | Always | In 1 condition |
| STAT2signal transducer and activator of transcription 2 | Always | In 1 condition |
| SUPT7LSPT7 like, STAGA complex subunit gamma | Always | In 1 condition |
| TTC7Atetratricopeptide repeat domain 7A | Always | In 1 condition |
| WASWASP actin nucleation promoting factor | Always | In 1 condition |
| ZPR1ZPR1 zinc finger | Always | In 1 condition |
| CASRcalcium sensing receptor | Very often (80–99%) | In 1 condition |
| CPA1carboxypeptidase A1 | Very often (80–99%) | In 1 condition |
| CTRCchymotrypsin C | Very often (80–99%) | In 1 condition |
| PRSS1serine protease 1 | Very often (80–99%) | In 1 condition |
| PRSS2serine protease 2 | Very often (80–99%) | In 1 condition |
| SLC35C1solute carrier family 35 member C1 | Very often (80–99%) | In 1 condition |
| TRPV6transient receptor potential cation channel subfamily V member 6 | Very often (80–99%) | In 1 condition |
| ABL1ABL proto-oncogene 1, non-receptor tyrosine kinase | Often (30–79%) | In 1 condition |
| ACAT1acetyl-CoA acetyltransferase 1 | Often (30–79%) | In 1 condition |
| ADAadenosine deaminase | Often (30–79%) | In 1 condition |
| AP1S3adaptor related protein complex 1 subunit sigma 3 | Often (30–79%) | In 1 condition |
Show 70 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| ASXL1ASXL transcriptional regulator 1 | Often (30–79%) | In 2 conditions |
| ATRXATRX chromatin remodeler | Often (30–79%) | In 1 condition |
| BCRBCR activator of RhoGEF and GTPase | Often (30–79%) | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Often (30–79%) | In 1 condition |
| CBLCbl proto-oncogene | Often (30–79%) | In 1 condition |
| CDH23cadherin related 23 | Often (30–79%) | In 1 condition |
| CHD7chromodomain helicase DNA binding protein 7 | Often (30–79%) | In 1 condition |
| DOCK11dedicator of cytokinesis 11 | Often (30–79%) | In 1 condition |
| HBBhemoglobin subunit beta | Often (30–79%) | In 3 conditions |
| HMOX1heme oxygenase 1 | Often (30–79%) | In 1 condition |
| IL2RGinterleukin 2 receptor subunit gamma | Often (30–79%) | In 1 condition |
| IL7Rinterleukin 7 receptor | Often (30–79%) | In 1 condition |
| KITKIT proto-oncogene, receptor tyrosine kinase | Often (30–79%) | In 1 condition |
| LPIN2lipin 2 | Often (30–79%) | In 1 condition |
| MEFVMEFV innate immunity regulator, pyrin | Often (30–79%) | In 3 conditions |
| NR3C1nuclear receptor subfamily 3 group C member 1 | Often (30–79%) | In 1 condition |
| NUDCD3NudC domain containing 3 | Often (30–79%) | In 1 condition |
| PSMB10proteasome 20S subunit beta 10 | Often (30–79%) | In 1 condition |
| PSMB9proteasome 20S subunit beta 9 | Often (30–79%) | In 1 condition |
| PTPN6protein tyrosine phosphatase non-receptor type 6 | Often (30–79%) | In 1 condition |
| RBCK1RANBP2-type and C3HC4-type zinc finger containing 1 | Often (30–79%) | In 1 condition |
| RBM8ARNA binding motif protein 8A | Often (30–79%) | In 1 condition |
| RMRPRNA component of mitochondrial RNA processing endoribonuclease | Often (30–79%) | In 1 condition |
| RUNX1RUNX family transcription factor 1 | Often (30–79%) | In 2 conditions |
| SRSF2serine and arginine rich splicing factor 2 | Often (30–79%) | In 2 conditions |
| TBK1TANK binding kinase 1 | Often (30–79%) | In 1 condition |
| TET2tet methylcytosine dioxygenase 2 | Often (30–79%) | In 5 conditions |
| TGFB1transforming growth factor beta 1 | Often (30–79%) | In 1 condition |
| TICAM1TIR domain containing adaptor molecule 1 | Often (30–79%) | In 1 condition |
| TLR3toll like receptor 3 | Often (30–79%) | In 1 condition |
| TNFRSF1ATNF receptor superfamily member 1A | Often (30–79%) | In 1 condition |
| TP53tumor protein p53 | Often (30–79%) | In 2 conditions |
| TRAF3TNF receptor associated factor 3 | Often (30–79%) | In 1 condition |
| UNC93B1unc-93B1 regulator of TLR signaling | Often (30–79%) | In 1 condition |
| USP48ubiquitin specific peptidase 48 | Often (30–79%) | In 1 condition |
| USP8ubiquitin specific peptidase 8 | Often (30–79%) | In 1 condition |
| ADA2adenosine deaminase 2 | Sometimes (5–29%) | In 1 condition |
| AGR2anterior gradient 2, protein disulphide isomerase family member | Sometimes (5–29%) | In 1 condition |
| BCORBCL6 corepressor | Sometimes (5–29%) | In 1 condition |
| CALRcalreticulin | Sometimes (5–29%) | In 2 conditions |
| CYP27B1cytochrome P450 family 27 subfamily B member 1 | Sometimes (5–29%) | In 1 condition |
| CYP2R1cytochrome P450 family 2 subfamily R member 1 | Sometimes (5–29%) | In 1 condition |
| FIP1L1factor interacting with PAPOLA and CPSF1 | Sometimes (5–29%) | In 1 condition |
| GATA2GATA binding protein 2 | Sometimes (5–29%) | In 1 condition |
| HMGCL3-hydroxy-3-methylglutaryl-CoA lyase | Sometimes (5–29%) | In 1 condition |
| IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma | Sometimes (5–29%) | In 2 conditions |
| IRF2BP2interferon regulatory factor 2 binding protein 2 | Sometimes (5–29%) | In 1 condition |
| JAK2Janus kinase 2 | Sometimes (5–29%) | In 4 conditions |
| LIG4DNA ligase 4 | Sometimes (5–29%) | In 1 condition |
| MPLMPL proto-oncogene, thrombopoietin receptor | Sometimes (5–29%) | In 2 conditions |
| NABP1nucleic acid binding protein 1 | Sometimes (5–29%) | In 1 condition |
| NPM1nucleophosmin 1 | Sometimes (5–29%) | In 1 condition |
| NUMA1nuclear mitotic apparatus protein 1 | Sometimes (5–29%) | In 1 condition |
| PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin | Sometimes (5–29%) | In 1 condition |
| PMLPML nuclear body scaffold | Sometimes (5–29%) | In 1 condition |
| PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha | Sometimes (5–29%) | In 1 condition |
| RARAretinoic acid receptor alpha | Sometimes (5–29%) | In 1 condition |
| SALL4spalt like transcription factor 4 | Sometimes (5–29%) | In 2 conditions |
| SH2B3SH2B adaptor protein 3 | Sometimes (5–29%) | In 1 condition |
| STAT3signal transducer and activator of transcription 3 | Sometimes (5–29%) | In 1 condition |
| STAT5Bsignal transducer and activator of transcription 5B | Sometimes (5–29%) | In 1 condition |
| TBL1XR1TBL1X/Y related 1 | Sometimes (5–29%) | In 1 condition |
| ZBTB16zinc finger and BTB domain containing 16 | Sometimes (5–29%) | In 1 condition |
| SF3B1splicing factor 3b subunit 1 | Rarely (1–4%) | In 1 condition |
| ANKRD26ankyrin repeat domain 26 | Not recorded | In 1 condition |
| CASKcalcium/calmodulin dependent serine protein kinase | Not recorded | In 1 condition |
| FERMT3FERM domain containing kindlin 3 | Not recorded | In 1 condition |
| G6PDglucose-6-phosphate dehydrogenase | Not recorded | In 1 condition |
| GATA1GATA binding protein 1 | Not recorded | In 1 condition |
| IFNGR1interferon gamma receptor 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks