Trait
Pain
An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage.
Summary
- Body system
- Constitutional symptom
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test98 genes linked to Pain
Changes in these genes cause rare conditions in which Pain is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| KDM6Blysine demethylase 6B | Always | In 1 condition |
| LRRC7leucine rich repeat containing 7 | Always | In 1 condition |
| TM2D3TM2 domain containing 3 | Always | In 1 condition |
| ZMYM3zinc finger MYM-type containing 3 | Always | In 1 condition |
| AP1S3adaptor related protein complex 1 subunit sigma 3 | Very often (80–99%) | In 1 condition |
| HBBhemoglobin subunit beta | Very often (80–99%) | In 1 condition |
| HOGA14-hydroxy-2-oxoglutarate aldolase 1 | Very often (80–99%) | In 1 condition |
| IL36RNinterleukin 36 receptor antagonist | Very often (80–99%) | In 1 condition |
| MEFVMEFV innate immunity regulator, pyrin | Very often (80–99%) | In 1 condition |
| PTPN6protein tyrosine phosphatase non-receptor type 6 | Very often (80–99%) | In 1 condition |
| ANGangiogenin | Often (30–79%) | In 1 condition |
| ANXA11annexin A11 | Often (30–79%) | In 1 condition |
| ATXN2ataxin 2 | Often (30–79%) | In 1 condition |
| CCNFcyclin F | Often (30–79%) | In 1 condition |
| CFAP410cilia and flagella associated protein 410 | Often (30–79%) | In 1 condition |
| CHCHD10coiled-coil-helix-coiled-coil-helix domain containing 10 | Often (30–79%) | In 1 condition |
| CHEK2checkpoint kinase 2 | Often (30–79%) | In 1 condition |
| CHMP2Bcharged multivesicular body protein 2B | Often (30–79%) | In 1 condition |
| COQ6coenzyme Q6, monooxygenase | Often (30–79%) | In 1 condition |
| DAOD-amino acid oxidase | Often (30–79%) | In 1 condition |
| DCTN1dynactin subunit 1 | Often (30–79%) | In 1 condition |
| ERBB4erb-b2 receptor tyrosine kinase 4 | Often (30–79%) | In 1 condition |
| EXT1exostosin glycosyltransferase 1 | Often (30–79%) | In 1 condition |
| EXT2exostosin glycosyltransferase 2 | Often (30–79%) | In 1 condition |
| FDXRferredoxin reductase | Often (30–79%) | In 1 condition |
| FIG4FIG4 phosphoinositide 5-phosphatase | Often (30–79%) | In 1 condition |
| FUSFUS RNA binding protein | Often (30–79%) | In 1 condition |
| GLE1GLE1 RNA export mediator | Often (30–79%) | In 1 condition |
| GLT8D1glycosyltransferase 8 domain containing 1 | Often (30–79%) | In 1 condition |
| GNA14G protein subunit alpha 14 | Often (30–79%) | In 2 conditions |
| HNRNPA1heterogeneous nuclear ribonucleoprotein A1 | Often (30–79%) | In 1 condition |
| KYkyphoscoliosis peptidase | Often (30–79%) | In 1 condition |
| LRP12LDL receptor related protein 12 | Often (30–79%) | In 1 condition |
| LZTR1leucine zipper like post translational regulator 1 | Often (30–79%) | In 1 condition |
| MATR3matrin 3 | Often (30–79%) | In 1 condition |
| MMEmembrane metalloendopeptidase | Often (30–79%) | In 1 condition |
| NEFHneurofilament heavy chain | Often (30–79%) | In 1 condition |
| NEK1NIMA related kinase 1 | Often (30–79%) | In 1 condition |
| NF2NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor | Often (30–79%) | In 1 condition |
| OPA3outer mitochondrial membrane lipid metabolism regulator OPA3 | Often (30–79%) | In 1 condition |
Show 58 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| OPTNoptineurin | Often (30–79%) | In 1 condition |
| PABPN1poly(A) binding protein nuclear 1 | Often (30–79%) | In 1 condition |
| PFN1profilin 1 | Often (30–79%) | In 1 condition |
| PRPHperipherin | Often (30–79%) | In 1 condition |
| RB1RB transcriptional corepressor 1 | Often (30–79%) | In 1 condition |
| SMARCB1SWI/SNF related BAF chromatin remodeling complex subunit B1 | Often (30–79%) | In 1 condition |
| SOD1superoxide dismutase 1 | Often (30–79%) | In 1 condition |
| SQSTM1sequestosome 1 | Often (30–79%) | In 1 condition |
| TAF15TATA-box binding protein associated factor 15 | Often (30–79%) | In 1 condition |
| TARDBPTAR DNA binding protein | Often (30–79%) | In 1 condition |
| TBK1TANK binding kinase 1 | Often (30–79%) | In 1 condition |
| TP53tumor protein p53 | Often (30–79%) | In 1 condition |
| TREM2triggering receptor expressed on myeloid cells 2 | Often (30–79%) | In 1 condition |
| UBQLN2ubiquilin 2 | Often (30–79%) | In 1 condition |
| UNC13Aunc-13 homolog A | Often (30–79%) | In 1 condition |
| VAPBVAMP associated protein B and C | Often (30–79%) | In 1 condition |
| VCPvalosin containing protein | Often (30–79%) | In 1 condition |
| ZFTAzinc finger translocation associated | Often (30–79%) | In 1 condition |
| AAGABalpha and gamma adaptin binding protein | Sometimes (5–29%) | In 1 condition |
| ABCA12ATP binding cassette subfamily A member 12 | Sometimes (5–29%) | In 1 condition |
| ALOX12Barachidonate 12-lipoxygenase, 12R type | Sometimes (5–29%) | In 1 condition |
| ALOXE3arachidonate epidermal lipoxygenase 3 | Sometimes (5–29%) | In 1 condition |
| ASPRV1aspartic peptidase retroviral like 1 | Sometimes (5–29%) | In 1 condition |
| CACNA1Scalcium voltage-gated channel subunit alpha1 S | Sometimes (5–29%) | In 1 condition |
| CARS2cysteinyl-tRNA synthetase 2, mitochondrial | Sometimes (5–29%) | In 1 condition |
| COL14A1collagen type XIV alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| COL1A1collagen type I alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| CYP4F22cytochrome P450 family 4 subfamily F member 22 | Sometimes (5–29%) | In 1 condition |
| DEPDC5DEP domain containing 5, GATOR1 subcomplex subunit | Sometimes (5–29%) | In 1 condition |
| FOXE1forkhead box E1 | Sometimes (5–29%) | In 1 condition |
| HABP2hyaluronan binding protein 2 | Sometimes (5–29%) | In 1 condition |
| HARS1histidyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| KCNE3potassium voltage-gated channel subfamily E regulatory subunit 3 | Sometimes (5–29%) | In 1 condition |
| LIPNlipase family member N | Sometimes (5–29%) | In 1 condition |
| LRP1LDL receptor related protein 1 | Sometimes (5–29%) | In 1 condition |
| MINPP1multiple inositol-polyphosphate phosphatase 1 | Sometimes (5–29%) | In 1 condition |
| NF1neurofibromin 1 | Sometimes (5–29%) | In 1 condition |
| NIPAL4NIPA like domain containing 4 | Sometimes (5–29%) | In 1 condition |
| NPRL2NPR2 like, GATOR1 complex subunit | Sometimes (5–29%) | In 1 condition |
| NPRL3NPR3 like, GATOR1 complex subunit | Sometimes (5–29%) | In 1 condition |
| PDGFBplatelet derived growth factor subunit B | Sometimes (5–29%) | In 1 condition |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Sometimes (5–29%) | In 1 condition |
| RASA1RAS p21 protein activator 1 | Sometimes (5–29%) | In 1 condition |
| REEP2receptor accessory protein 2 | Sometimes (5–29%) | In 1 condition |
| SCN3Asodium voltage-gated channel alpha subunit 3 | Sometimes (5–29%) | In 1 condition |
| SCN4Asodium voltage-gated channel alpha subunit 4 | Sometimes (5–29%) | In 1 condition |
| SDR9C7short chain dehydrogenase/reductase family 9C member 7 | Sometimes (5–29%) | In 1 condition |
| SULT2B1sulfotransferase family 2B member 1 | Sometimes (5–29%) | In 1 condition |
| TGM1transglutaminase 1 | Sometimes (5–29%) | In 1 condition |
| ACADVLacyl-CoA dehydrogenase very long chain | Rarely (1–4%) | In 1 condition |
| CATcatalase | Rarely (1–4%) | In 1 condition |
| RNU4-2RNA, U4 small nuclear 2 | Rarely (1–4%) | In 1 condition |
| COQ7coenzyme Q7, hydroxylase | Not recorded | In 1 condition |
| FERMT3FERM domain containing kindlin 3 | Not recorded | In 1 condition |
| MFN2mitofusin 2 | Not recorded | In 1 condition |
| NGLY1N-glycanase 1 | Not recorded | In 1 condition |
| SCN11Asodium voltage-gated channel alpha subunit 11 | Not recorded | In 1 condition |
| SCN9Asodium voltage-gated channel alpha subunit 9 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
- Abdominal pain327 genes
- Joint pain202 genes
- Muscle ache176 genes
- Chest pain143 genes
- Bone pain90 genes
- Back pain68 genes
- Limb pain18 genes
- Flank pain15 genes
- Chronic pain14 genes
- Painful menstruation14 genes
- Hip pain13 genes
- Epigastric pain12 genes
- Erythromelalgia10 genes
- Shoulder pain7 genes
- Allodynia5 genes
- Episodic pain3 genes
- Lower jaw pain3 genes
- Sore throat3 genes
- Groin pain2 genes
- Jaw pain2 genes
- Tendon pain2 genes
- Anal pain1 gene
- Costochondral pain1 gene
- Neuralgia
- Pain in head and neck region
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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