Trait

Intestinal pseudo-obstruction

A functional rather than mechanical obstruction of the intestines, associated with manifestations that resemble those caused by an intestinal obstruction, including distension, abdominal pain, nausea, vomiting, constipation or diarrhea, in an individual in whom a mechanical blockage has been excluded.

HPO HP:0004389

Also called: Intestinal pseudoobstruction
Body system: Abnormality of the digestive system

This page as data

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36 genes linked to Intestinal pseudo-obstruction

Changes in these genes cause rare conditions in which Intestinal pseudo-obstruction is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
LIG3DNA ligase 3	Always	In 1 condition
POLGDNA polymerase gamma, catalytic subunit	Always	In 4 conditions
RAD21RAD21 cohesin complex component	Always	In 1 condition
SGO1shugoshin 1	Always	In 1 condition
BRCA1BRCA1 DNA repair associated	Often (30–79%)	In 1 condition
BRCA2BRCA2 DNA repair associated	Often (30–79%)	In 1 condition
CDKN2Acyclin dependent kinase inhibitor 2A	Often (30–79%)	In 1 condition
ERBB3erb-b2 receptor tyrosine kinase 3	Often (30–79%)	In 1 condition
KRASKRas proto-oncogene, GTPase	Often (30–79%)	In 1 condition
PALB2partner and localizer of BRCA2	Often (30–79%)	In 1 condition
PALLDpalladin, cytoskeletal associated protein	Often (30–79%)	In 1 condition
RABL3RAB, member of RAS oncogene family like 3	Often (30–79%)	In 1 condition
SMAD4SMAD family member 4	Often (30–79%)	In 1 condition
TP53tumor protein p53	Often (30–79%)	In 1 condition
TYMPthymidine phosphorylase	Often (30–79%)	In 1 condition
HNRNPKheterogeneous nuclear ribonucleoprotein K	Sometimes (5–29%)	In 2 conditions
MT-CO1mitochondrially encoded cytochrome c oxidase I	Sometimes (5–29%)	In 1 condition
MT-CO2mitochondrially encoded cytochrome c oxidase II	Sometimes (5–29%)	In 1 condition
MT-CO3mitochondrially encoded cytochrome c oxidase III	Sometimes (5–29%)	In 1 condition
MT-ND1mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1	Sometimes (5–29%)	In 1 condition
MT-ND4mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4	Sometimes (5–29%)	In 1 condition
MT-ND5mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5	Sometimes (5–29%)	In 1 condition
MT-ND6mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6	Sometimes (5–29%)	In 1 condition
MT-TFmitochondrially encoded tRNA-Phe (UUU/C)	Sometimes (5–29%)	In 1 condition
MT-THmitochondrially encoded tRNA-His (CAU/C)	Sometimes (5–29%)	In 1 condition
MT-TL1mitochondrially encoded tRNA-Leu (UUA/G) 1	Sometimes (5–29%)	In 1 condition
MT-TQmitochondrially encoded tRNA-Gln (CAA/G)	Sometimes (5–29%)	In 1 condition
MT-TS1mitochondrially encoded tRNA-Ser (UCN) 1	Sometimes (5–29%)	In 1 condition
MT-TS2mitochondrially encoded tRNA-Ser (AGU/C) 2	Sometimes (5–29%)	In 1 condition
MT-TWmitochondrially encoded tRNA-Trp (UGA/G)	Sometimes (5–29%)	In 1 condition
MYH11myosin heavy chain 11	Sometimes (5–29%)	In 1 condition
SMOsmoothened, frizzled class receptor	Sometimes (5–29%)	In 1 condition
TWNKtwinkle mtDNA helicase	Sometimes (5–29%)	In 2 conditions
ACTG2actin gamma 2, smooth muscle	Not recorded	In 1 condition
FLNAfilamin A	Not recorded	In 1 condition
IDSiduronate 2-sulfatase	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormality of the intestine Gastrointestinal dysmotility

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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