Trait
Spontaneous fracture
Clinical name: Pathologic fracture
A pathologic fracture occurs when a bone breaks in an area that is weakened secondarily to another disease process such as tumor, infection, and certain inherited bone disorders. A pathologic fracture can occur without a degree of trauma required to cause fracture in healthy bone.
Summary
- Body system
- Abnormality of the musculoskeletal system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test63 genes linked to Spontaneous fracture
Changes in these genes cause rare conditions in which Spontaneous fracture is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| METMET proto-oncogene, receptor tyrosine kinase | Always | In 1 condition |
| PLOD3procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 | Always | In 1 condition |
| SLC4A2solute carrier family 4 member 2 | Always | In 1 condition |
| ATP7BATPase copper transporting beta | Very often (80–99%) | In 1 condition |
| CCND1cyclin D1 | Very often (80–99%) | In 1 condition |
| BANF1barrier to autointegration nuclear assembly factor 1 | Often (30–79%) | In 1 condition |
| CTC1CST telomere replication complex component 1 | Often (30–79%) | In 1 condition |
| EFEMP2EGF-like fibulin extracellular matrix protein 2 | Often (30–79%) | In 1 condition |
| FBLN5fibulin 5 | Often (30–79%) | In 1 condition |
| LIFRLIF receptor subunit alpha | Often (30–79%) | In 1 condition |
| LTBP1latent transforming growth factor beta binding protein 1 | Often (30–79%) | In 1 condition |
| ALKALK receptor tyrosine kinase | Sometimes (5–29%) | In 1 condition |
| ASXL1ASXL transcriptional regulator 1 | Sometimes (5–29%) | In 1 condition |
| ATL1atlastin GTPase 1 | Sometimes (5–29%) | In 1 condition |
| ATL3atlastin GTPase 3 | Sometimes (5–29%) | In 1 condition |
| B2Mbeta-2-microglobulin | Sometimes (5–29%) | In 1 condition |
| CBLCbl proto-oncogene | Sometimes (5–29%) | In 1 condition |
| GBA1glucosylceramidase beta 1 | Sometimes (5–29%) | In 2 conditions |
| HACE1HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 | Sometimes (5–29%) | In 1 condition |
| IDH1isocitrate dehydrogenase (NADP(+)) 1 | Sometimes (5–29%) | In 1 condition |
| IDH2isocitrate dehydrogenase (NADP(+)) 2 | Sometimes (5–29%) | In 1 condition |
| IER3IP1immediate early response 3 interacting protein 1 | Sometimes (5–29%) | In 1 condition |
| LIN28Blin-28 RNA binding posttranscriptional regulator B | Sometimes (5–29%) | In 1 condition |
| LMO1LIM domain only 1 | Sometimes (5–29%) | In 1 condition |
| MYCNMYCN proto-oncogene, bHLH transcription factor | Sometimes (5–29%) | In 1 condition |
| PHOX2Bpaired like homeobox 2B | Sometimes (5–29%) | In 1 condition |
| PTH1Rparathyroid hormone 1 receptor | Sometimes (5–29%) | In 2 conditions |
| RECQL4RecQ like helicase 4 | Sometimes (5–29%) | In 1 condition |
| RUNX1RUNX family transcription factor 1 | Sometimes (5–29%) | In 1 condition |
| SCARB2scavenger receptor class B member 2 | Sometimes (5–29%) | In 1 condition |
| SLC34A1solute carrier family 34 member 1 | Sometimes (5–29%) | In 1 condition |
| SLC34A3solute carrier family 34 member 3 | Sometimes (5–29%) | In 1 condition |
| SPTLC1serine palmitoyltransferase long chain base subunit 1 | Sometimes (5–29%) | In 1 condition |
| SPTLC2serine palmitoyltransferase long chain base subunit 2 | Sometimes (5–29%) | In 1 condition |
| SRSF2serine and arginine rich splicing factor 2 | Sometimes (5–29%) | In 1 condition |
| TET2tet methylcytosine dioxygenase 2 | Sometimes (5–29%) | In 1 condition |
| VIPAS39VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog | Sometimes (5–29%) | In 1 condition |
| VPS33BVPS33B late endosome and lysosome associated | Sometimes (5–29%) | In 1 condition |
| CHEK2checkpoint kinase 2 | Rarely (1–4%) | In 1 condition |
| HNRNPA1heterogeneous nuclear ribonucleoprotein A1 | Rarely (1–4%) | In 1 condition |
Show 23 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| HNRNPA2B1heterogeneous nuclear ribonucleoprotein A2/B1 | Rarely (1–4%) | In 1 condition |
| RB1RB transcriptional corepressor 1 | Rarely (1–4%) | In 1 condition |
| SLC7A7solute carrier family 7 member 7 | Rarely (1–4%) | In 1 condition |
| SMPD1sphingomyelin phosphodiesterase 1 | Rarely (1–4%) | In 1 condition |
| TP53tumor protein p53 | Rarely (1–4%) | In 1 condition |
| VCPvalosin containing protein | Rarely (1–4%) | In 1 condition |
| AGAaspartylglucosaminidase | Not recorded | In 1 condition |
| AGXTalanine--glyoxylate aminotransferase | Not recorded | In 1 condition |
| ALPLalkaline phosphatase, biomineralization associated | Not recorded | In 1 condition |
| B3GALT6beta-1,3-galactosyltransferase 6 | Not recorded | In 1 condition |
| GKglycerol kinase | Not recorded | In 1 condition |
| GNASGNAS complex locus | Not recorded | In 1 condition |
| GNPTABN-acetylglucosamine-1-phosphate transferase subunits alpha and beta | Not recorded | In 1 condition |
| LRP5LDL receptor related protein 5 | Not recorded | In 1 condition |
| MTAPmethylthioadenosine phosphorylase | Not recorded | In 1 condition |
| NOTCH2notch receptor 2 | Not recorded | In 1 condition |
| OCRLOCRL inositol polyphosphate-5-phosphatase | Not recorded | In 1 condition |
| SLC4A1solute carrier family 4 member 1 (Diego blood group) | Not recorded | In 1 condition |
| TCIRG1T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 | Not recorded | In 1 condition |
| TNFRSF11ATNF receptor superfamily member 11a | Not recorded | In 1 condition |
| TREM2triggering receptor expressed on myeloid cells 2 | Not recorded | In 2 conditions |
| TYROBPtransmembrane immune signaling adaptor TYROBP | Not recorded | In 1 condition |
| UROSuroporphyrinogen III synthase | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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