Trait
Acne
A skin condition in which there is an increase in sebum secretion by the pilosebaceous apparatus associated with open comedones (blackheads), closed comedones (whiteheads), and pustular nodules (papules, pustules, and cysts).
Summary
- Also called
- Breaking out
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test58 genes linked to Acne
Changes in these genes cause rare conditions in which Acne is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ESR1estrogen receptor 1 | Always | In 2 conditions |
| LRRC7leucine rich repeat containing 7 | Always | In 1 condition |
| PSMD12proteasome 26S subunit, non-ATPase 12 | Always | In 1 condition |
| PSTPIP1proline-serine-threonine phosphatase interacting protein 1 | Always | In 2 conditions |
| SLCO2A1solute carrier organic anion transporter family member 2A1 | Always | In 3 conditions |
| WNT4Wnt family member 4 | Always | In 2 conditions |
| ECM1extracellular matrix protein 1 | Very often (80–99%) | In 1 condition |
| SH3PXD2BSH3 and PX domains 2B | Very often (80–99%) | In 2 conditions |
| ARVCFARVCF delta catenin family member | Often (30–79%) | In 1 condition |
| ATRXATRX chromatin remodeler | Often (30–79%) | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Often (30–79%) | In 1 condition |
| C4Acomplement C4A (Chido/Rodgers blood group) | Often (30–79%) | In 1 condition |
| CCR1C-C motif chemokine receptor 1 | Often (30–79%) | In 1 condition |
| CDH23cadherin related 23 | Often (30–79%) | In 1 condition |
| COMTcatechol-O-methyltransferase | Often (30–79%) | In 1 condition |
| CYP11B1cytochrome P450 family 11 subfamily B member 1 | Often (30–79%) | In 1 condition |
| ERAP1endoplasmic reticulum aminopeptidase 1 | Often (30–79%) | In 1 condition |
| FASFas cell surface death receptor | Often (30–79%) | In 1 condition |
| GP1BBglycoprotein Ib platelet subunit beta | Often (30–79%) | In 1 condition |
| HIRAhistone cell cycle regulator | Often (30–79%) | In 1 condition |
| HLA-Bmajor histocompatibility complex, class I, B | Often (30–79%) | In 1 condition |
| HPGD15-hydroxyprostaglandin dehydrogenase | Often (30–79%) | In 1 condition |
| IFNGR1interferon gamma receptor 1 | Often (30–79%) | In 1 condition |
| IL10interleukin 10 | Often (30–79%) | In 1 condition |
| IL12Ainterleukin 12A | Often (30–79%) | In 1 condition |
| IL12A-AS1IL12A antisense RNA 1 | Often (30–79%) | In 1 condition |
| IL23Rinterleukin 23 receptor | Often (30–79%) | In 1 condition |
| JMJD1Cjumonji domain containing 1C | Often (30–79%) | In 1 condition |
| KLRC4killer cell lectin like receptor C4 | Often (30–79%) | In 1 condition |
| LHCGRluteinizing hormone/choriogonadotropin receptor | Often (30–79%) | In 1 condition |
| LPIN2lipin 2 | Often (30–79%) | In 1 condition |
| MEFVMEFV innate immunity regulator, pyrin | Often (30–79%) | In 2 conditions |
| NR3C1nuclear receptor subfamily 3 group C member 1 | Often (30–79%) | In 2 conditions |
| PTPN6protein tyrosine phosphatase non-receptor type 6 | Often (30–79%) | In 1 condition |
| RREB1ras responsive element binding protein 1 | Often (30–79%) | In 1 condition |
| SEC24CSEC24 homolog C, COPII component | Often (30–79%) | In 1 condition |
| STAT4signal transducer and activator of transcription 4 | Often (30–79%) | In 1 condition |
| TBX1T-box transcription factor 1 | Often (30–79%) | In 2 conditions |
| TLR4toll like receptor 4 | Often (30–79%) | In 1 condition |
| TP53tumor protein p53 | Often (30–79%) | In 1 condition |
Show 18 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| UBAC2UBA domain containing 2 | Often (30–79%) | In 1 condition |
| UFD1ubiquitin recognition factor in ER associated degradation 1 | Often (30–79%) | In 1 condition |
| USP48ubiquitin specific peptidase 48 | Often (30–79%) | In 1 condition |
| USP8ubiquitin specific peptidase 8 | Often (30–79%) | In 1 condition |
| XYLT1xylosyltransferase 1 | Often (30–79%) | In 1 condition |
| AIPAHR interacting HSP90 co-chaperone | Sometimes (5–29%) | In 1 condition |
| ARMC5armadillo repeat containing 5 | Sometimes (5–29%) | In 1 condition |
| GNASGNAS complex locus | Sometimes (5–29%) | In 1 condition |
| GPR101G protein-coupled receptor 101 | Sometimes (5–29%) | In 1 condition |
| H6PDhexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase | Sometimes (5–29%) | In 1 condition |
| KDM1Alysine demethylase 1A | Sometimes (5–29%) | In 1 condition |
| MEIS2Meis homeobox 2 | Sometimes (5–29%) | In 1 condition |
| ARandrogen receptor | Rarely (1–4%) | In 1 condition |
| AGAaspartylglucosaminidase | Not recorded | In 1 condition |
| FGFR2fibroblast growth factor receptor 2 | Not recorded | In 1 condition |
| PAPSS23'-phosphoadenosine 5'-phosphosulfate synthase 2 | Not recorded | In 1 condition |
| PRKACAprotein kinase cAMP-activated catalytic subunit alpha | Not recorded | In 1 condition |
| XIAPX-linked inhibitor of apoptosis | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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