Trait
Memory impairment
An impairment of memory as manifested by a reduced ability to remember things such as dates and names, and increased forgetfulness.
Summary
- Also called
- Amnesia, Forgetfulness, Memory loss, Memory problems, Poor memory
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test153 genes linked to Memory impairment
Changes in these genes cause rare conditions in which Memory impairment is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| APOEapolipoprotein E | Always | In 2 conditions |
| ARHGEF15Rho guanine nucleotide exchange factor 15 | Always | In 1 condition |
| CSF1Rcolony stimulating factor 1 receptor | Always | In 1 condition |
| CTSAcathepsin A | Always | In 1 condition |
| CYLDCYLD lysine 63 deubiquitinase | Always | In 1 condition |
| EIF2B2eukaryotic translation initiation factor 2B subunit beta | Always | In 1 condition |
| JPH3junctophilin 3 | Always | In 2 conditions |
| MPV17mitochondrial inner membrane protein MPV17 | Always | In 1 condition |
| NOTCH3notch receptor 3 | Always | In 2 conditions |
| PSEN2presenilin 2 | Always | In 2 conditions |
| RAB3ARAB3A, member RAS oncogene family | Always | In 1 condition |
| RRP12ribosomal RNA processing 12 homolog | Always | In 2 conditions |
| SCO2synthesis of cytochrome C oxidase 2 | Always | In 1 condition |
| ADA2adenosine deaminase 2 | Very often (80–99%) | In 1 condition |
| APPamyloid beta precursor protein | Very often (80–99%) | In 2 conditions |
| CHMP2Bcharged multivesicular body protein 2B | Very often (80–99%) | In 3 conditions |
| FMR1fragile X messenger ribonucleoprotein 1 | Very often (80–99%) | In 2 conditions |
| GNEglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | Very often (80–99%) | In 1 condition |
| GRNgranulin precursor | Very often (80–99%) | In 3 conditions |
| MAPTmicrotubule associated protein tau | Very often (80–99%) | In 5 conditions |
| PRKAR1Bprotein kinase cAMP-dependent type I regulatory subunit beta | Very often (80–99%) | In 1 condition |
| PSEN1presenilin 1 | Very often (80–99%) | In 4 conditions |
| SORL1sortilin related receptor 1 | Very often (80–99%) | In 1 condition |
| SQSTM1sequestosome 1 | Very often (80–99%) | In 1 condition |
| TMEM106Btransmembrane protein 106B | Very often (80–99%) | In 2 conditions |
| TOMM40translocase of outer mitochondrial membrane 40 | Very often (80–99%) | In 1 condition |
| TREM2triggering receptor expressed on myeloid cells 2 | Very often (80–99%) | In 6 conditions |
| TYROBPtransmembrane immune signaling adaptor TYROBP | Very often (80–99%) | In 2 conditions |
| VCPvalosin containing protein | Very often (80–99%) | In 3 conditions |
| ARSAarylsulfatase A | Often (30–79%) | In 1 condition |
| ATXN1ataxin 1 | Often (30–79%) | In 1 condition |
| CAMTA1calmodulin binding transcription activator 1 | Often (30–79%) | In 1 condition |
| DNMT1DNA methyltransferase 1 | Often (30–79%) | In 3 conditions |
| FGF14fibroblast growth factor 14 | Often (30–79%) | In 1 condition |
| GOSR2golgi SNAP receptor complex member 2 | Often (30–79%) | In 1 condition |
| HTThuntingtin | Often (30–79%) | In 1 condition |
| LAMB1laminin subunit beta 1 | Often (30–79%) | In 1 condition |
| MT-CO1mitochondrially encoded cytochrome c oxidase I | Often (30–79%) | In 1 condition |
| MT-CO2mitochondrially encoded cytochrome c oxidase II | Often (30–79%) | In 1 condition |
| MT-CO3mitochondrially encoded cytochrome c oxidase III | Often (30–79%) | In 1 condition |
Show 113 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| MT-ND1mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 | Often (30–79%) | In 1 condition |
| MT-ND4mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 | Often (30–79%) | In 1 condition |
| MT-ND5mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 | Often (30–79%) | In 1 condition |
| MT-ND6mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 | Often (30–79%) | In 1 condition |
| MT-TFmitochondrially encoded tRNA-Phe (UUU/C) | Often (30–79%) | In 1 condition |
| MT-THmitochondrially encoded tRNA-His (CAU/C) | Often (30–79%) | In 1 condition |
| MT-TL1mitochondrially encoded tRNA-Leu (UUA/G) 1 | Often (30–79%) | In 1 condition |
| MT-TQmitochondrially encoded tRNA-Gln (CAA/G) | Often (30–79%) | In 1 condition |
| MT-TS1mitochondrially encoded tRNA-Ser (UCN) 1 | Often (30–79%) | In 1 condition |
| MT-TS2mitochondrially encoded tRNA-Ser (AGU/C) 2 | Often (30–79%) | In 1 condition |
| MT-TWmitochondrially encoded tRNA-Trp (UGA/G) | Often (30–79%) | In 1 condition |
| NF1neurofibromin 1 | Often (30–79%) | In 1 condition |
| NIPA1NIPA magnesium transporter 1 | Often (30–79%) | In 1 condition |
| NIPA2NIPA magnesium transporter 2 | Often (30–79%) | In 1 condition |
| POU4F1POU class 4 homeobox 1 | Often (30–79%) | In 1 condition |
| PRNPprion protein (Kanno blood group) | Often (30–79%) | In 4 conditions |
| PSAPprosaposin | Often (30–79%) | In 1 condition |
| SIM1SIM bHLH transcription factor 1 | Often (30–79%) | In 1 condition |
| SLC25A13solute carrier family 25 member 13 | Often (30–79%) | In 1 condition |
| SLC2A3solute carrier family 2 member 3 | Often (30–79%) | In 1 condition |
| SPG11SPG11 vesicle trafficking associated, spatacsin | Often (30–79%) | In 1 condition |
| SPG7SPG7 matrix AAA peptidase subunit, paraplegin | Often (30–79%) | In 2 conditions |
| TUBG1tubulin gamma 1 | Often (30–79%) | In 1 condition |
| VAMP1vesicle associated membrane protein 1 | Often (30–79%) | In 2 conditions |
| ABCD1ATP binding cassette subfamily D member 1 | Sometimes (5–29%) | In 2 conditions |
| ACSF3acyl-CoA synthetase family member 3 | Sometimes (5–29%) | In 1 condition |
| AKT1AKT serine/threonine kinase 1 | Sometimes (5–29%) | In 1 condition |
| ALDH18A1aldehyde dehydrogenase 18 family member A1 | Sometimes (5–29%) | In 1 condition |
| AMACRalpha-methylacyl-CoA racemase | Sometimes (5–29%) | In 1 condition |
| ARMC5armadillo repeat containing 5 | Sometimes (5–29%) | In 1 condition |
| ATMATM serine/threonine kinase | Sometimes (5–29%) | In 1 condition |
| ATN1atrophin 1 | Sometimes (5–29%) | In 1 condition |
| ATRXATRX chromatin remodeler | Sometimes (5–29%) | In 1 condition |
| ATXN3ataxin 3 | Sometimes (5–29%) | In 3 conditions |
| BAP1BRCA1 associated deubiquitinase 1 | Sometimes (5–29%) | In 1 condition |
| BMPR1Abone morphogenetic protein receptor type 1A | Sometimes (5–29%) | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Sometimes (5–29%) | In 1 condition |
| BRCA2BRCA2 DNA repair associated | Sometimes (5–29%) | In 1 condition |
| C4Acomplement C4A (Chido/Rodgers blood group) | Sometimes (5–29%) | In 1 condition |
| CCR1C-C motif chemokine receptor 1 | Sometimes (5–29%) | In 1 condition |
| CDH23cadherin related 23 | Sometimes (5–29%) | In 1 condition |
| CHEK2checkpoint kinase 2 | Sometimes (5–29%) | In 1 condition |
| CMPK2cytidine/uridine monophosphate kinase 2 | Sometimes (5–29%) | In 1 condition |
| CPceruloplasmin | Sometimes (5–29%) | In 1 condition |
| EPCAMepithelial cell adhesion molecule | Sometimes (5–29%) | In 1 condition |
| ERAP1endoplasmic reticulum aminopeptidase 1 | Sometimes (5–29%) | In 1 condition |
| FASFas cell surface death receptor | Sometimes (5–29%) | In 1 condition |
| GNASGNAS complex locus | Sometimes (5–29%) | In 1 condition |
| GRIN2Aglutamate ionotropic receptor NMDA type subunit 2A | Sometimes (5–29%) | In 1 condition |
| HLA-Bmajor histocompatibility complex, class I, B | Sometimes (5–29%) | In 1 condition |
| HMBShydroxymethylbilane synthase | Sometimes (5–29%) | In 1 condition |
| IFNGR1interferon gamma receptor 1 | Sometimes (5–29%) | In 1 condition |
| IL10interleukin 10 | Sometimes (5–29%) | In 1 condition |
| IL12Ainterleukin 12A | Sometimes (5–29%) | In 1 condition |
| IL12A-AS1IL12A antisense RNA 1 | Sometimes (5–29%) | In 1 condition |
| IL23Rinterleukin 23 receptor | Sometimes (5–29%) | In 1 condition |
| JAM2junctional adhesion molecule 2 | Sometimes (5–29%) | In 2 conditions |
| KDM1Alysine demethylase 1A | Sometimes (5–29%) | In 1 condition |
| KLRC4killer cell lectin like receptor C4 | Sometimes (5–29%) | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Sometimes (5–29%) | In 1 condition |
| MEFVMEFV innate immunity regulator, pyrin | Sometimes (5–29%) | In 1 condition |
| MLH1mutL homolog 1 | Sometimes (5–29%) | In 1 condition |
| MMACHCmetabolism of cobalamin associated C | Sometimes (5–29%) | In 1 condition |
| MSH2mutS homolog 2 | Sometimes (5–29%) | In 1 condition |
| MSH6mutS homolog 6 | Sometimes (5–29%) | In 1 condition |
| MUTYHmutY DNA glycosylase | Sometimes (5–29%) | In 1 condition |
| MYD88MYD88 innate immune signal transduction adaptor | Sometimes (5–29%) | In 1 condition |
| MYORGmyogenesis regulating glycosidase | Sometimes (5–29%) | In 3 conditions |
| NAA60N-alpha-acetyltransferase 60, NatF catalytic subunit | Sometimes (5–29%) | In 2 conditions |
| NF2NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor | Sometimes (5–29%) | In 2 conditions |
| NPATnuclear protein, coactivator of histone transcription | Sometimes (5–29%) | In 1 condition |
| NPTX1neuronal pentraxin 1 | Sometimes (5–29%) | In 1 condition |
| NR3C1nuclear receptor subfamily 3 group C member 1 | Sometimes (5–29%) | In 1 condition |
| PDGFBplatelet derived growth factor subunit B | Sometimes (5–29%) | In 4 conditions |
| PDGFRBplatelet derived growth factor receptor beta | Sometimes (5–29%) | In 2 conditions |
| PIDD1p53-induced death domain protein 1 | Sometimes (5–29%) | In 1 condition |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Sometimes (5–29%) | In 2 conditions |
| PMS1PMS1 homolog 1, mismatch repair system component | Sometimes (5–29%) | In 1 condition |
| PMS2PMS1 homolog 2, mismatch repair system component | Sometimes (5–29%) | In 1 condition |
| POLD1DNA polymerase delta 1, catalytic subunit | Sometimes (5–29%) | In 1 condition |
| POLEDNA polymerase epsilon, catalytic subunit | Sometimes (5–29%) | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Sometimes (5–29%) | In 1 condition |
| PRORPprotein only RNase P catalytic subunit | Sometimes (5–29%) | In 1 condition |
| REEP2receptor accessory protein 2 | Sometimes (5–29%) | In 1 condition |
| RPS20ribosomal protein S20 | Sometimes (5–29%) | In 1 condition |
| SEMA4Asemaphorin 4A | Sometimes (5–29%) | In 1 condition |
| SLC20A2solute carrier family 20 member 2 | Sometimes (5–29%) | In 2 conditions |
| SMARCB1SWI/SNF related BAF chromatin remodeling complex subunit B1 | Sometimes (5–29%) | In 1 condition |
| SMARCE1SWI/SNF related BAF chromatin remodeling complex subunit E1 | Sometimes (5–29%) | In 1 condition |
| SMOsmoothened, frizzled class receptor | Sometimes (5–29%) | In 1 condition |
| STAT4signal transducer and activator of transcription 4 | Sometimes (5–29%) | In 1 condition |
| STUB1STIP1 homology and U-box containing protein 1 | Sometimes (5–29%) | In 1 condition |
| SUFUSUFU negative regulator of hedgehog signaling | Sometimes (5–29%) | In 1 condition |
| TERTtelomerase reverse transcriptase | Sometimes (5–29%) | In 1 condition |
| TGFBR2transforming growth factor beta receptor 2 | Sometimes (5–29%) | In 1 condition |
| TIA1TIA1 cytotoxic granule associated RNA binding protein | Sometimes (5–29%) | In 1 condition |
| TLR4toll like receptor 4 | Sometimes (5–29%) | In 1 condition |
| TP53tumor protein p53 | Sometimes (5–29%) | In 1 condition |
| TRAF7TNF receptor associated factor 7 | Sometimes (5–29%) | In 1 condition |
| TREX1three prime repair exonuclease 1 | Sometimes (5–29%) | In 1 condition |
| TWNKtwinkle mtDNA helicase | Sometimes (5–29%) | In 1 condition |
| UBAC2UBA domain containing 2 | Sometimes (5–29%) | In 1 condition |
| UGT1A1UDP glucuronosyltransferase family 1 member A1 | Sometimes (5–29%) | In 1 condition |
| USP48ubiquitin specific peptidase 48 | Sometimes (5–29%) | In 1 condition |
| USP8ubiquitin specific peptidase 8 | Sometimes (5–29%) | In 1 condition |
| XPR1xenotropic and polytropic retrovirus receptor 1 | Sometimes (5–29%) | In 3 conditions |
| AFG3L2AFG3 like matrix AAA peptidase subunit 2 | Rarely (1–4%) | In 1 condition |
| ABCA7ATP binding cassette subfamily A member 7 | Not recorded | In 1 condition |
| ECM1extracellular matrix protein 1 | Not recorded | In 1 condition |
| EIF2B1eukaryotic translation initiation factor 2B subunit alpha | Not recorded | In 1 condition |
| HLA-DQB1major histocompatibility complex, class II, DQ beta 1 | Not recorded | In 1 condition |
| PRKCGprotein kinase C gamma | Not recorded | In 1 condition |
| SPASTspastin | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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