Skip to content
Use your HSA or FSA funds

Gene

CLPP

caseinolytic mitochondrial matrix peptidase proteolytic subunit

Summary

Cytogenetic location
19p13.3
Coordinates
Chromosome 19: 6,361,531–6,370,242 (GRCh38)
Exons
6 exons across 8.7 kb
Protein
277 amino acids
MANE Select transcript
ENST00000245816.11NM_006012.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Female Infertility

    • Diminished or absent ability of a female to achieve conception.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong

How CLPP is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 19, with a bracket where CLPP sits. CLPP and 28 genes near it on chromosome 19, from 5,865,887 to 6,865,886.Chromosome 1919p13.3p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.436 Mb6.2 Mb6.4 Mb6.6 Mb6.8 MbFUT5: 5,865,826–5,870,540, reverse strandFUT5: 5,866,171–5,903,787, reverse strandNDUFA11: 5,891,207–5,904,006, reverse strandVMAC: 5,904,723–5,910,853, forward strandVMAC: 5,904,841–5,914,707, forward strandCAPS: 5,912,339–5,916,211, forward strandCAPSRANBP3: 5,916,138–5,978,288, reverse strandRANBP3RFX2: 5,993,164–6,199,572, reverse strandRFX2ACSBG2: 6,135,247–6,193,094, forward strandACSBG2MLLT1: 6,210,377–6,280,029, reverse strandMLLT1ACER1: 6,306,030–6,333,612, reverse strandACER1CLPP: 6,361,531–6,370,242, forward strandCLPPALKBH7: 6,372,715–6,377,261, forward strandALKBH7PSPN: 6,375,148–6,379,058, reverse strandPSPNGTF2F1: 6,379,545–6,393,981, reverse strandGTF2F1KHSRP: 6,413,102–6,424,824, reverse strandKHSRPSLC25A41: 6,426,037–6,433,779, reverse strandSLC25A23: 6,436,068–6,465,203, reverse strandSLC25A23CRB3: 6,463,777–6,467,239, forward strandCRB3DENND1C: 6,467,207–6,482,557, reverse strandDENND1CTUBB4A: 6,494,308–6,502,848, reverse strandTUBB4ATNFSF9: 6,530,985–6,535,926, forward strandTNFSF9CD70: 6,583,183–6,604,103, reverse strandCD70TNFSF14: 6,658,085–6,670,621, reverse strandTNFSF14C3: 6,677,704–6,730,562, reverse strandC3GPR108: 6,729,914–6,737,665, reverse strandGPR108TRIP10: 6,737,925–6,751,530, forward strandTRIP10SH2D3A: 6,751,899–6,768,109, reverse strandSH2D3AVAV1: 6,772,676–6,857,366, forward strandVAV1Diagram of CLPP: 6 exons on the forward strand of chromosome 19Exon 1: 2 known disease-causing sitesExon 2: 1 known disease-causing siteExon 3: 2 known disease-causing sitesExon 4: 3 known disease-causing sitesExon 5: 1 known disease-causing siteExon 1: 6,361,531–6,361,772, 242 basesExon 2: 6,361,869–6,361,940, 72 basesExon 3: 6,362,446–6,362,542, 97 basesExon 4: 6,364,452–6,364,639, 188 basesExon 5: 6,366,258–6,366,363, 106 basesExon 6: 6,368,538–6,370,242, 1,705 bases1234565′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.4 kb of the gene's 8.7 kb; 834 of those bases code for the protein.

How a genome test reads CLPP

11

positions in CLPP where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 8.7 kb of CLPP, introns included, not only the 2.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CLPP gene: caseinolytic mitochondrial matrix peptidase proteolytic subunit. Retrieved 17 October 2026, from https://dantelabs.com/genes/clpp

Vancouver

Dante Labs. CLPP gene: caseinolytic mitochondrial matrix peptidase proteolytic subunit [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/clpp

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test