Trait
Cleft hand
Clinical name: Ectrodactyly
A condition in which middle parts of the hands and/or feet (digits and meta-carpals and -tarsals) are missing giving a cleft appearance. The severity is very variable ranging from slightly hypoplastic 3rd toe/fingers over absent 2nd or 3rd toes/fingers as far as oligo- or monodactyl hands and/or feet.
Summary
- Also called
- Lobster claw hand
Reference genomeGRCh38hg38
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Get my Genome Test15 genes linked to Cleft hand
Changes in these genes cause rare conditions in which Cleft hand is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| FLVCR1FLVCR choline and heme transporter 1 | Always | In 1 condition |
| UBA2ubiquitin like modifier activating enzyme 2 | Always | In 1 condition |
| BHLHA9basic helix-loop-helix family member a9 | Very often (80–99%) | In 2 conditions |
| CDH3cadherin 3 | Very often (80–99%) | In 1 condition |
| FGFR1fibroblast growth factor receptor 1 | Very often (80–99%) | In 2 conditions |
| TP63tumor protein p63 | Very often (80–99%) | In 3 conditions |
| WNT7AWnt family member 7A | Very often (80–99%) | In 1 condition |
| MBTPS2membrane bound transcription factor peptidase, site 2 | Often (30–79%) | In 2 conditions |
| PORCNporcupine O-acyltransferase | Often (30–79%) | In 1 condition |
| CDKN1Ccyclin dependent kinase inhibitor 1C | Sometimes (5–29%) | In 1 condition |
| HMGA2high mobility group AT-hook 2 | Sometimes (5–29%) | In 1 condition |
| IGF2insulin like growth factor 2 | Sometimes (5–29%) | In 1 condition |
| PLAG1PLAG1 zinc finger | Sometimes (5–29%) | In 1 condition |
| WLSWnt ligand secretion mediator | Sometimes (5–29%) | In 1 condition |
| DLX5distal-less homeobox 5 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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