Trait
Webbed 2nd and 3rd toes
Clinical name: 2-3 toe syndactyly
Syndactyly with fusion of toes two and three.
Summary
- Also called
- 2-3 syndactyly of feet, 2-3 toe soft tissue syndactyly, 2-3 toes syndactyly, partial or complete syndactyly 2nd-3rd toes, Syndactyly of second and third toes, Toe syndactyly, 2-3
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Webbed 2nd and 3rd toes, and the rest of your genome, with one test.
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Get my Genome Test97 genes linked to Webbed 2nd and 3rd toes
Changes in these genes cause rare conditions in which Webbed 2nd and 3rd toes is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| BBS7Bardet-Biedl syndrome 7 | Always | In 1 condition |
| CLCF1cardiotrophin like cytokine factor 1 | Always | In 1 condition |
| CSGALNACT1chondroitin sulfate N-acetylgalactosaminyltransferase 1 | Always | In 1 condition |
| DDX11DEAD/H-box helicase 11 | Always | In 1 condition |
| DHCR77-dehydrocholesterol reductase | Always | In 2 conditions |
| HEPHL1hephaestin like 1 | Always | In 1 condition |
| IL11RAinterleukin 11 receptor subunit alpha | Always | In 1 condition |
| ITPR1inositol 1,4,5-trisphosphate receptor type 1 | Always | In 1 condition |
| JKAMPJNK1/MAPK8 associated membrane protein | Always | In 1 condition |
| MEIS2Meis homeobox 2 | Always | In 1 condition |
| PIGYphosphatidylinositol glycan anchor biosynthesis class Y | Always | In 1 condition |
| RAD21RAD21 cohesin complex component | Always | In 1 condition |
| RNU6ATACRNA, U6atac small nuclear | Always | In 1 condition |
| SIK3SIK family kinase 3 | Always | In 1 condition |
| SLC12A2solute carrier family 12 member 2 | Always | In 1 condition |
| SMC3structural maintenance of chromosomes 3 | Always | In 1 condition |
| TAF4TATA-box binding protein associated factor 4 | Always | In 1 condition |
| TM2D3TM2 domain containing 3 | Always | In 1 condition |
| TRA2Btransformer 2 beta homolog | Always | In 1 condition |
| WDPCPWD repeat containing planar cell polarity effector | Always | In 1 condition |
| BHLHA9basic helix-loop-helix family member a9 | Very often (80–99%) | In 1 condition |
| GNEglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | Very often (80–99%) | In 2 conditions |
| ALDH1A2aldehyde dehydrogenase 1 family member A2 | Often (30–79%) | In 1 condition |
| BCORBCL6 corepressor | Often (30–79%) | In 2 conditions |
| CERT1ceramide transporter 1 | Often (30–79%) | In 1 condition |
| CNTNAP1contactin associated protein 1 | Often (30–79%) | In 1 condition |
| EBPEBP cholestenol delta-isomerase | Often (30–79%) | In 2 conditions |
| FDFT1farnesyl-diphosphate farnesyltransferase 1 | Often (30–79%) | In 1 condition |
| FGFR1fibroblast growth factor receptor 1 | Often (30–79%) | In 1 condition |
| FGFR2fibroblast growth factor receptor 2 | Often (30–79%) | In 2 conditions |
| H4C9H4 clustered histone 9 | Often (30–79%) | In 1 condition |
| HOXD13homeobox D13 | Often (30–79%) | In 1 condition |
| IFT172intraflagellar transport 172 | Often (30–79%) | In 1 condition |
| IFT43intraflagellar transport 43 | Often (30–79%) | In 2 conditions |
| KMT2Alysine methyltransferase 2A | Often (30–79%) | In 1 condition |
| KMT2Blysine methyltransferase 2B | Often (30–79%) | In 1 condition |
| LRRC8Cleucine rich repeat containing 8 VRAC subunit C | Often (30–79%) | In 1 condition |
| MED25mediator complex subunit 25 | Often (30–79%) | In 2 conditions |
| MEF2Cmyocyte enhancer factor 2C | Often (30–79%) | In 1 condition |
| MYCNMYCN proto-oncogene, bHLH transcription factor | Often (30–79%) | In 2 conditions |
Show 57 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| MYRFmyelin regulatory factor | Often (30–79%) | In 1 condition |
| NBNnibrin | Often (30–79%) | In 1 condition |
| NEDD4LNEDD4 like E3 ubiquitin protein ligase | Often (30–79%) | In 1 condition |
| PDE6Dphosphodiesterase 6D | Often (30–79%) | In 1 condition |
| PSMD12proteasome 26S subunit, non-ATPase 12 | Often (30–79%) | In 1 condition |
| RALARAS like proto-oncogene A | Often (30–79%) | In 1 condition |
| SCARF2scavenger receptor class F member 2 | Often (30–79%) | In 1 condition |
| SHANK3SH3 and multiple ankyrin repeat domains 3 | Often (30–79%) | In 1 condition |
| SHMT2serine hydroxymethyltransferase 2 | Often (30–79%) | In 1 condition |
| SOX5SRY-box transcription factor 5 | Often (30–79%) | In 1 condition |
| TRIOtrio Rho guanine nucleotide exchange factor | Often (30–79%) | In 2 conditions |
| TRMT5tRNA methyltransferase 5 | Often (30–79%) | In 1 condition |
| AP1G1adaptor related protein complex 1 subunit gamma 1 | Sometimes (5–29%) | In 1 condition |
| ARMC9armadillo repeat containing 9 | Sometimes (5–29%) | In 1 condition |
| CDC45cell division cycle 45 | Sometimes (5–29%) | In 1 condition |
| CNOT2CCR4-NOT transcription complex subunit 2 | Sometimes (5–29%) | In 1 condition |
| CTCFCCCTC-binding factor | Sometimes (5–29%) | In 1 condition |
| DDX6DEAD-box helicase 6 | Sometimes (5–29%) | In 1 condition |
| FBXW11F-box and WD repeat domain containing 11 | Sometimes (5–29%) | In 1 condition |
| JARID2jumonji and AT-rich interaction domain containing 2 | Sometimes (5–29%) | In 1 condition |
| KCNJ2potassium inwardly rectifying channel subfamily J member 2 | Sometimes (5–29%) | In 1 condition |
| KCNJ5potassium inwardly rectifying channel subfamily J member 5 | Sometimes (5–29%) | In 1 condition |
| KDM5Alysine demethylase 5A | Sometimes (5–29%) | In 1 condition |
| MAB21L2mab-21 like 2 | Sometimes (5–29%) | In 1 condition |
| MAPRE2microtubule associated protein RP/EB family member 2 | Sometimes (5–29%) | In 1 condition |
| PHIPPHIP subunit of CUL4-Ring ligase complex | Sometimes (5–29%) | In 1 condition |
| PLAAT3phospholipase A and acyltransferase 3 | Sometimes (5–29%) | In 1 condition |
| POLR3ARNA polymerase III subunit A | Sometimes (5–29%) | In 1 condition |
| PUF60poly(U) binding splicing factor 60 | Sometimes (5–29%) | In 1 condition |
| RAI1retinoic acid induced 1 | Sometimes (5–29%) | In 1 condition |
| RBPJrecombination signal binding protein for immunoglobulin kappa J region | Sometimes (5–29%) | In 1 condition |
| SATB1SATB homeobox 1 | Sometimes (5–29%) | In 1 condition |
| STAG1STAG1 cohesin complex component | Sometimes (5–29%) | In 1 condition |
| SYT1synaptotagmin 1 | Sometimes (5–29%) | In 1 condition |
| TTI2TELO2 interacting protein 2 | Sometimes (5–29%) | In 1 condition |
| UBE2Aubiquitin conjugating enzyme E2 A | Sometimes (5–29%) | In 1 condition |
| ADNPactivity dependent neuroprotector homeobox | Rarely (1–4%) | In 1 condition |
| APC2APC regulator of Wnt signaling pathway 2 | Rarely (1–4%) | In 1 condition |
| MAN1B1mannosidase alpha class 1B member 1 | Rarely (1–4%) | In 1 condition |
| NSD1nuclear receptor binding SET domain protein 1 | Rarely (1–4%) | In 1 condition |
| TBCKTBC1 domain containing kinase | Rarely (1–4%) | In 1 condition |
| ARCN1archain 1 coat protein complex I subunit delta | Not recorded | In 1 condition |
| BMP2bone morphogenetic protein 2 | Not recorded | In 1 condition |
| BMPR1Bbone morphogenetic protein receptor type 1B | Not recorded | In 1 condition |
| CEP55centrosomal protein 55 | Not recorded | In 1 condition |
| GDF5growth differentiation factor 5 | Not recorded | In 1 condition |
| KCTD1potassium channel tetramerization domain containing 1 | Not recorded | In 1 condition |
| LMBR1limb development membrane protein 1 | Not recorded | In 1 condition |
| NIPBLNIPBL cohesin loading factor | Not recorded | In 1 condition |
| NOGnoggin | Not recorded | In 1 condition |
| SALL1spalt like transcription factor 1 | Not recorded | In 1 condition |
| SLC12A6solute carrier family 12 member 6 | Not recorded | In 1 condition |
| SMAD4SMAD family member 4 | Not recorded | In 1 condition |
| TBX15T-box transcription factor 15 | Not recorded | In 1 condition |
| TP63tumor protein p63 | Not recorded | In 1 condition |
| TXNL4Athioredoxin like 4A | Not recorded | In 1 condition |
| ZMIZ1zinc finger MIZ-type containing 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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