Trait

Thick nail

Clinical name: Onychogryphosis

Onychogryphosis is a disorder of nail plate growth that is clinically characterized by an opaque, yellow-brown thickening of the nail plate with associated gross hyperkeratosis, elongation, and increased curvature.

HPO HP:0001805

Also called: Thickened nails, Dystrophic thickened nails, Onychogryposis
Body system: Abnormality of the integument

This page as data

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19 genes linked to Thick nail

Changes in these genes cause rare conditions in which Thick nail is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
ADAM17ADAM metallopeptidase domain 17	Always	In 2 conditions
ITGB4integrin subunit beta 4	Always	In 1 condition
LMNAlamin A/C	Always	In 1 condition
COL7A1collagen type VII alpha 1 chain	Very often (80–99%)	In 1 condition
CTSCcathepsin C	Often (30–79%)	In 2 conditions
HPGD15-hydroxyprostaglandin dehydrogenase	Often (30–79%)	In 1 condition
KRT83keratin 83	Often (30–79%)	In 1 condition
WDR19WD repeat domain 19	Often (30–79%)	In 1 condition
FZD6frizzled class receptor 6	Sometimes (5–29%)	In 1 condition
GJB2gap junction protein beta 2	Sometimes (5–29%)	In 1 condition
GJB6gap junction protein beta 6	Sometimes (5–29%)	In 1 condition
IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Sometimes (5–29%)	In 2 conditions
KRT14keratin 14	Sometimes (5–29%)	In 1 condition
KRT5keratin 5	Sometimes (5–29%)	In 2 conditions
LORICRINloricrin cornified envelope precursor protein	Sometimes (5–29%)	In 1 condition
KRT16keratin 16	Not recorded	In 1 condition
KRT6Akeratin 6A	Not recorded	In 1 condition
TP63tumor protein p63	Not recorded	In 1 condition
ZSWIM6zinc finger SWIM-type containing 6	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Abnormality of the nail

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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