Trait
Absent nails
Clinical name: Anonychia
Aplasia of the nail.
Summary
- Also called
- Aplastic nails
- Body system
- Abnormality of the integument
Reference genomeGRCh38hg38
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Get my Genome Test33 genes linked to Absent nails
Changes in these genes cause rare conditions in which Absent nails is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ATP6V1B2ATPase H+ transporting V1 subunit B2 | Always | In 1 condition |
| DSPdesmoplakin | Always | In 1 condition |
| HOXA13homeobox A13 | Always | In 1 condition |
| RBBP8RB binding protein 8, endonuclease | Always | In 1 condition |
| RSPO4R-spondin 4 | Always | In 1 condition |
| LRP4LDL receptor related protein 4 | Very often (80–99%) | In 1 condition |
| COL17A1collagen type XVII alpha 1 chain | Often (30–79%) | In 2 conditions |
| COL7A1collagen type VII alpha 1 chain | Often (30–79%) | In 5 conditions |
| FIG4FIG4 phosphoinositide 5-phosphatase | Often (30–79%) | In 1 condition |
| ITGB4integrin subunit beta 4 | Often (30–79%) | In 2 conditions |
| KCNH1potassium voltage-gated channel subfamily H member 1 | Often (30–79%) | In 1 condition |
| LAMA3laminin subunit alpha 3 | Often (30–79%) | In 2 conditions |
| LAMB3laminin subunit beta 3 | Often (30–79%) | In 2 conditions |
| LAMC2laminin subunit gamma 2 | Often (30–79%) | In 2 conditions |
| MMP1matrix metallopeptidase 1 | Often (30–79%) | In 1 condition |
| ZBTB20zinc finger and BTB domain containing 20 | Often (30–79%) | In 1 condition |
| ACTG2actin gamma 2, smooth muscle | Sometimes (5–29%) | In 1 condition |
| ATP2A2ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 | Sometimes (5–29%) | In 1 condition |
| GJB6gap junction protein beta 6 | Sometimes (5–29%) | In 1 condition |
| PORCNporcupine O-acyltransferase | Sometimes (5–29%) | In 1 condition |
| SLC25A24solute carrier family 25 member 24 | Rarely (1–4%) | In 1 condition |
| ARID1BAT-rich interaction domain 1B | Not recorded | In 1 condition |
| GRHL2grainyhead like transcription factor 2 | Not recorded | In 1 condition |
| ITGA6integrin subunit alpha 6 | Not recorded | In 1 condition |
| LMX1BLIM homeobox transcription factor 1 beta | Not recorded | In 1 condition |
| NOGnoggin | Not recorded | In 1 condition |
| PLECplectin | Not recorded | In 1 condition |
| RIPK4receptor interacting serine/threonine kinase 4 | Not recorded | In 1 condition |
| ROR2ROR family WNT receptor 2 | Not recorded | In 1 condition |
| TBC1D24TBC1 domain family member 24 | Not recorded | In 1 condition |
| TP63tumor protein p63 | Not recorded | In 1 condition |
| WNT10AWnt family member 10A | Not recorded | In 1 condition |
| WNT7AWnt family member 7A | Not recorded | In 2 conditions |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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