Trait
Decreased ability to sweat
Clinical name: Hypohidrosis
Abnormally diminished capacity to sweat.
Summary
- Also called
- Decreased sweating, Sweating, decreased, Impaired sweating, Inadequate sweating, Oligohidrosis
- Body system
- Abnormality of the integument
Reference genomeGRCh38hg38
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Get my Genome Test82 genes linked to Decreased ability to sweat
Changes in these genes cause rare conditions in which Decreased ability to sweat is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CERS3ceramide synthase 3 | Always | In 2 conditions |
| COG6component of oligomeric golgi complex 6 | Always | In 3 conditions |
| CST6cystatin E/M | Always | In 1 condition |
| EDAectodysplasin A | Always | In 2 conditions |
| EDARectodysplasin A receptor | Always | In 4 conditions |
| EDARADDEDAR associated via death domain | Always | In 5 conditions |
| FAM111BFAM111 trypsin like peptidase B | Always | In 1 condition |
| GJB2gap junction protein beta 2 | Always | In 2 conditions |
| IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma | Always | In 2 conditions |
| KDF1keratinocyte differentiation factor 1 | Always | In 2 conditions |
| LRRC7leucine rich repeat containing 7 | Always | In 1 condition |
| ABCA12ATP binding cassette subfamily A member 12 | Very often (80–99%) | In 2 conditions |
| ALOX12Barachidonate 12-lipoxygenase, 12R type | Very often (80–99%) | In 3 conditions |
| ALOXE3arachidonate epidermal lipoxygenase 3 | Very often (80–99%) | In 4 conditions |
| ASPRV1aspartic peptidase retroviral like 1 | Very often (80–99%) | In 1 condition |
| CLCF1cardiotrophin like cytokine factor 1 | Very often (80–99%) | In 1 condition |
| CRLF1cytokine receptor like factor 1 | Very often (80–99%) | In 1 condition |
| CYP4F22cytochrome P450 family 4 subfamily F member 22 | Very often (80–99%) | In 1 condition |
| EDA2Rectodysplasin A2 receptor | Very often (80–99%) | In 1 condition |
| ELOVL4ELOVL fatty acid elongase 4 | Very often (80–99%) | In 1 condition |
| ELP1elongator acetyltransferase complex subunit 1 | Very often (80–99%) | In 1 condition |
| FLGfilaggrin | Very often (80–99%) | In 1 condition |
| GLAgalactosidase alpha | Very often (80–99%) | In 2 conditions |
| KCTD1potassium channel tetramerization domain containing 1 | Very often (80–99%) | In 2 conditions |
| LIFRLIF receptor subunit alpha | Very often (80–99%) | In 1 condition |
| LIPNlipase family member N | Very often (80–99%) | In 1 condition |
| LRP6LDL receptor related protein 6 | Very often (80–99%) | In 1 condition |
| NFKBIANFKB inhibitor alpha | Very often (80–99%) | In 2 conditions |
| NIPAL4NIPA like domain containing 4 | Very often (80–99%) | In 3 conditions |
| PNPLA1patatin like domain 1, omega-hydroxyceramide transacylase | Very often (80–99%) | In 1 condition |
| SDR9C7short chain dehydrogenase/reductase family 9C member 7 | Very often (80–99%) | In 2 conditions |
| STSsteroid sulfatase | Very often (80–99%) | In 3 conditions |
| SULT2B1sulfotransferase family 2B member 1 | Very often (80–99%) | In 2 conditions |
| TGM1transglutaminase 1 | Very often (80–99%) | In 3 conditions |
| TRAF6TNF receptor associated factor 6 | Very often (80–99%) | In 1 condition |
| TSPEARthrombospondin type laminin G domain and EAR repeats | Very often (80–99%) | In 1 condition |
| ARXaristaless related homeobox | Often (30–79%) | In 1 condition |
| COL11A1collagen type XI alpha 1 chain | Often (30–79%) | In 1 condition |
| CSTBcystatin B | Often (30–79%) | In 1 condition |
| ERCC4ERCC excision repair 4, endonuclease catalytic subunit | Often (30–79%) | In 1 condition |
Show 42 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| ERCC6ERCC excision repair 6, chromatin remodeling factor | Often (30–79%) | In 1 condition |
| ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit | Often (30–79%) | In 1 condition |
| KRT14keratin 14 | Often (30–79%) | In 3 conditions |
| MADDMAP kinase activating death domain | Often (30–79%) | In 1 condition |
| MBTPS2membrane bound transcription factor peptidase, site 2 | Often (30–79%) | In 2 conditions |
| PKP1plakophilin 1 | Often (30–79%) | In 1 condition |
| POLA1DNA polymerase alpha 1, catalytic subunit | Often (30–79%) | In 1 condition |
| PORCNporcupine O-acyltransferase | Often (30–79%) | In 1 condition |
| PRDM12PR/SET domain 12 | Often (30–79%) | In 1 condition |
| RIPK4receptor interacting serine/threonine kinase 4 | Often (30–79%) | In 1 condition |
| ROGDIrogdi atypical leucine zipper | Often (30–79%) | In 1 condition |
| SHANK3SH3 and multiple ankyrin repeat domains 3 | Often (30–79%) | In 1 condition |
| SLC13A5solute carrier family 13 member 5 | Often (30–79%) | In 1 condition |
| SMARCAD1SNF2 related chromatin remodeling ATPase with DExD box 1 | Often (30–79%) | In 1 condition |
| SOX10SRY-box transcription factor 10 | Often (30–79%) | In 2 conditions |
| TRIP4thyroid hormone receptor interactor 4 | Often (30–79%) | In 1 condition |
| WNT10AWnt family member 10A | Often (30–79%) | In 3 conditions |
| ADAT3adenosine deaminase tRNA specific 3 | Sometimes (5–29%) | In 1 condition |
| ALDH3A2aldehyde dehydrogenase 3 family member A2 | Sometimes (5–29%) | In 1 condition |
| ALX4ALX homeobox 4 | Sometimes (5–29%) | In 1 condition |
| ARNT2aryl hydrocarbon receptor nuclear translocator 2 | Sometimes (5–29%) | In 1 condition |
| FGFR1fibroblast growth factor receptor 1 | Sometimes (5–29%) | In 1 condition |
| GHRgrowth hormone receptor | Sometimes (5–29%) | In 1 condition |
| GJB6gap junction protein beta 6 | Sometimes (5–29%) | In 1 condition |
| GMPPAGDP-mannose pyrophosphorylase A | Sometimes (5–29%) | In 1 condition |
| HESX1HESX homeobox 1 | Sometimes (5–29%) | In 1 condition |
| ITPR3inositol 1,4,5-trisphosphate receptor type 3 | Sometimes (5–29%) | In 1 condition |
| LEF1lymphoid enhancer binding factor 1 | Sometimes (5–29%) | In 1 condition |
| NECTIN1nectin cell adhesion molecule 1 | Sometimes (5–29%) | In 1 condition |
| OTX2orthodenticle homeobox 2 | Sometimes (5–29%) | In 1 condition |
| PROKR2prokineticin receptor 2 | Sometimes (5–29%) | In 1 condition |
| SOX2SRY-box transcription factor 2 | Sometimes (5–29%) | In 1 condition |
| SOX3SRY-box transcription factor 3 | Sometimes (5–29%) | In 1 condition |
| TP63tumor protein p63 | Sometimes (5–29%) | In 4 conditions |
| CASKcalcium/calmodulin dependent serine protein kinase | Not recorded | In 1 condition |
| CLDN10claudin 10 | Not recorded | In 1 condition |
| COQ2coenzyme Q2, polyprenyltransferase | Not recorded | In 1 condition |
| CTNScystinosin, lysosomal cystine transporter | Not recorded | In 1 condition |
| HEXBhexosaminidase subunit beta | Not recorded | In 1 condition |
| SCN9Asodium voltage-gated channel alpha subunit 9 | Not recorded | In 1 condition |
| STIM1stromal interaction molecule 1 | Not recorded | In 1 condition |
| ZFHX2zinc finger homeobox 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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