Trait
Split foot
A condition in which middle parts of the foot (toes and metatarsals) are missing giving a cleft appearance. The severity is very variable ranging from slightly hypoplastic 3rd toe over absent 2nd or 3rd toes as far as oligo- or monodactyl feet.
Summary
- Also called
- Lobster-claw foot deformity, Split-foot, Foot ectrodactyly
Reference genomeGRCh38hg38
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Get my Genome Test14 genes linked to Split foot
Changes in these genes cause rare conditions in which Split foot is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| DLX5distal-less homeobox 5 | Always | In 3 conditions |
| UBA2ubiquitin like modifier activating enzyme 2 | Always | In 1 condition |
| MAP3K20mitogen-activated protein kinase kinase kinase 20 | Very often (80–99%) | In 2 conditions |
| TP63tumor protein p63 | Very often (80–99%) | In 7 conditions |
| BTRCbeta-transducin repeat containing E3 ubiquitin protein ligase | Often (30–79%) | In 1 condition |
| DLX6distal-less homeobox 6 | Often (30–79%) | In 1 condition |
| EPS15L1epidermal growth factor receptor pathway substrate 15 like 1 | Often (30–79%) | In 1 condition |
| FBXW4F-box and WD repeat domain containing 4 | Often (30–79%) | In 1 condition |
| SEM1SEM1 26S proteasome subunit | Often (30–79%) | In 1 condition |
| WNT10BWnt family member 10B | Often (30–79%) | In 2 conditions |
| FGFR2fibroblast growth factor receptor 2 | Sometimes (5–29%) | In 1 condition |
| GLI3GLI family zinc finger 3 | Sometimes (5–29%) | In 1 condition |
| LEF1lymphoid enhancer binding factor 1 | Sometimes (5–29%) | In 1 condition |
| PORCNporcupine O-acyltransferase | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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