Trait
Fused toes
Clinical name: Toe syndactyly
Webbing or fusion of the toes, involving soft parts only or including bone structure. Bony fusions are referred to as "bony" Syndactyly if the fusion occurs in a radio-ulnar axis. Fusions of bones of the toes in a proximo-distal axis are referred to as "Symphalangism".
Summary
- Also called
- Webbed toes, Foot syndactyly, Syndactyly of feet, Syndactyly of toes
Reference genomeGRCh38hg38
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Get my Genome Test137 genes linked to Fused toes
Changes in these genes cause rare conditions in which Fused toes is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CCNQcyclin Q | Always | In 2 conditions |
| DONSONDNA replication fork stabilization factor DONSON | Always | In 1 condition |
| EN1engrailed homeobox 1 | Always | In 1 condition |
| MEGF8multiple EGF like domains 8 | Always | In 1 condition |
| MRPS28mitochondrial ribosomal protein S28 | Always | In 1 condition |
| POLR3GLRNA polymerase III subunit GL | Always | In 1 condition |
| PUM1pumilio RNA binding family member 1 | Always | In 1 condition |
| RAB23RAB23, member RAS oncogene family | Always | In 2 conditions |
| SCNM1sodium channel modifier 1 | Always | In 1 condition |
| BHLHA9basic helix-loop-helix family member a9 | Very often (80–99%) | In 1 condition |
| BRD4bromodomain containing 4 | Very often (80–99%) | In 1 condition |
| FGFR2fibroblast growth factor receptor 2 | Very often (80–99%) | In 8 conditions |
| GJA1gap junction protein alpha 1 | Very often (80–99%) | In 1 condition |
| HDAC8histone deacetylase 8 | Very often (80–99%) | In 2 conditions |
| HOXD13homeobox D13 | Very often (80–99%) | In 1 condition |
| IRF6interferon regulatory factor 6 | Very often (80–99%) | In 1 condition |
| LMBR1limb development membrane protein 1 | Very often (80–99%) | In 2 conditions |
| MAU2MAU2 sister chromatid cohesion factor | Very often (80–99%) | In 1 condition |
| MYCNMYCN proto-oncogene, bHLH transcription factor | Very often (80–99%) | In 1 condition |
| NECTIN1nectin cell adhesion molecule 1 | Very often (80–99%) | In 1 condition |
| NIPBLNIPBL cohesin loading factor | Very often (80–99%) | In 2 conditions |
| NR4A2nuclear receptor subfamily 4 group A member 2 | Very often (80–99%) | In 1 condition |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Very often (80–99%) | In 1 condition |
| RAD21RAD21 cohesin complex component | Very often (80–99%) | In 1 condition |
| RIPK4receptor interacting serine/threonine kinase 4 | Very often (80–99%) | In 1 condition |
| SMC1Astructural maintenance of chromosomes 1A | Very often (80–99%) | In 1 condition |
| SMC3structural maintenance of chromosomes 3 | Very often (80–99%) | In 2 conditions |
| SMOC1SPARC related modular calcium binding 1 | Very often (80–99%) | In 2 conditions |
| TBR1T-box brain transcription factor 1 | Very often (80–99%) | In 1 condition |
| TP63tumor protein p63 | Very often (80–99%) | In 5 conditions |
| APCAPC regulator of Wnt signaling pathway | Often (30–79%) | In 1 condition |
| B3GLCTbeta 3-glucosyltransferase | Often (30–79%) | In 1 condition |
| CPLANE1ciliogenesis and planar polarity effector complex subunit 1 | Often (30–79%) | In 1 condition |
| ESCO2establishment of sister chromatid cohesion N-acetyltransferase 2 | Often (30–79%) | In 1 condition |
| FGFR1fibroblast growth factor receptor 1 | Often (30–79%) | In 1 condition |
| FLI1Fli-1 proto-oncogene, ETS transcription factor | Often (30–79%) | In 1 condition |
| FRAS1Fraser extracellular matrix complex subunit 1 | Often (30–79%) | In 1 condition |
| FREM2FRAS1 related extracellular matrix 2 | Often (30–79%) | In 1 condition |
| GLI3GLI family zinc finger 3 | Often (30–79%) | In 3 conditions |
| GPC3glypican 3 | Often (30–79%) | In 1 condition |
Show 97 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| GPC4glypican 4 | Often (30–79%) | In 1 condition |
| GRIP1glutamate receptor interacting protein 1 | Often (30–79%) | In 1 condition |
| HDAC4histone deacetylase 4 | Often (30–79%) | In 1 condition |
| IQSEC2IQ motif and Sec7 domain ArfGEF 2 | Often (30–79%) | In 1 condition |
| KIF7kinesin family member 7 | Often (30–79%) | In 1 condition |
| LRP4LDL receptor related protein 4 | Often (30–79%) | In 1 condition |
| MIR17HGmiR-17-92a-1 cluster host gene | Often (30–79%) | In 1 condition |
| NOGnoggin | Often (30–79%) | In 1 condition |
| PIGYphosphatidylinositol glycan anchor biosynthesis class Y | Often (30–79%) | In 1 condition |
| PSAT1phosphoserine aminotransferase 1 | Often (30–79%) | In 1 condition |
| RAI1retinoic acid induced 1 | Often (30–79%) | In 1 condition |
| SC5Dsterol-C5-desaturase | Often (30–79%) | In 1 condition |
| SHHsonic hedgehog signaling molecule | Often (30–79%) | In 1 condition |
| SMAD2SMAD family member 2 | Often (30–79%) | In 1 condition |
| SMOsmoothened, frizzled class receptor | Often (30–79%) | In 2 conditions |
| TSHZ3teashirt zinc finger homeobox 3 | Often (30–79%) | In 1 condition |
| WLSWnt ligand secretion mediator | Often (30–79%) | In 1 condition |
| WNT7AWnt family member 7A | Often (30–79%) | In 1 condition |
| ARL6IP6ARF like GTPase 6 interacting protein 6 | Sometimes (5–29%) | In 1 condition |
| BCRBCR activator of RhoGEF and GTPase | Sometimes (5–29%) | In 1 condition |
| BMS1BMS1 ribosome biogenesis factor | Sometimes (5–29%) | In 1 condition |
| BRCA1BRCA1 DNA repair associated | Sometimes (5–29%) | In 1 condition |
| BRCA2BRCA2 DNA repair associated | Sometimes (5–29%) | In 1 condition |
| BRIP1BRCA1 interacting DNA helicase 1 | Sometimes (5–29%) | In 1 condition |
| CD96CD96 molecule | Sometimes (5–29%) | In 2 conditions |
| CEP120centrosomal protein 120 | Sometimes (5–29%) | In 1 condition |
| CRKLCRK like proto-oncogene, adaptor protein | Sometimes (5–29%) | In 1 condition |
| CUL4Bcullin 4B | Sometimes (5–29%) | In 1 condition |
| DACT1dishevelled binding antagonist of beta catenin 1 | Sometimes (5–29%) | In 1 condition |
| DLL4delta like canonical Notch ligand 4 | Sometimes (5–29%) | In 1 condition |
| DYNC2H1dynein cytoplasmic 2 heavy chain 1 | Sometimes (5–29%) | In 1 condition |
| DYNC2I1dynein 2 intermediate chain 1 | Sometimes (5–29%) | In 1 condition |
| DYNC2I2dynein 2 intermediate chain 2 | Sometimes (5–29%) | In 1 condition |
| DYNC2LI1dynein cytoplasmic 2 light intermediate chain 1 | Sometimes (5–29%) | In 1 condition |
| ERCC4ERCC excision repair 4, endonuclease catalytic subunit | Sometimes (5–29%) | In 1 condition |
| FAAP100FA core complex associated protein 100 | Sometimes (5–29%) | In 1 condition |
| FANCAFA complementation group A | Sometimes (5–29%) | In 1 condition |
| FANCBFA complementation group B | Sometimes (5–29%) | In 1 condition |
| FANCCFA complementation group C | Sometimes (5–29%) | In 1 condition |
| FANCD2FA complementation group D2 | Sometimes (5–29%) | In 1 condition |
| FANCEFA complementation group E | Sometimes (5–29%) | In 1 condition |
| FANCFFA complementation group F | Sometimes (5–29%) | In 1 condition |
| FANCGFA complementation group G | Sometimes (5–29%) | In 1 condition |
| FANCIFA complementation group I | Sometimes (5–29%) | In 1 condition |
| FANCLFA complementation group L | Sometimes (5–29%) | In 1 condition |
| FANCMFA complementation group M | Sometimes (5–29%) | In 1 condition |
| FBXO11F-box protein 11 | Sometimes (5–29%) | In 1 condition |
| FGF10fibroblast growth factor 10 | Sometimes (5–29%) | In 1 condition |
| FGFR3fibroblast growth factor receptor 3 | Sometimes (5–29%) | In 1 condition |
| GNA11G protein subunit alpha 11 | Sometimes (5–29%) | In 1 condition |
| H3-3AH3.3 histone A | Sometimes (5–29%) | In 1 condition |
| IFT140intraflagellar transport 140 | Sometimes (5–29%) | In 1 condition |
| IFT172intraflagellar transport 172 | Sometimes (5–29%) | In 1 condition |
| IFT80intraflagellar transport 80 | Sometimes (5–29%) | In 1 condition |
| ITGB4integrin subunit beta 4 | Sometimes (5–29%) | In 1 condition |
| KIAA0753KIAA0753 | Sometimes (5–29%) | In 1 condition |
| MAD2L2mitotic arrest deficient 2 like 2 | Sometimes (5–29%) | In 1 condition |
| MAPK1mitogen-activated protein kinase 1 | Sometimes (5–29%) | In 1 condition |
| MEF2Cmyocyte enhancer factor 2C | Sometimes (5–29%) | In 1 condition |
| NEK9NIMA related kinase 9 | Sometimes (5–29%) | In 1 condition |
| NXNnucleoredoxin | Sometimes (5–29%) | In 1 condition |
| OTUD6BOTU deubiquitinase 6B | Sometimes (5–29%) | In 1 condition |
| PALB2partner and localizer of BRCA2 | Sometimes (5–29%) | In 1 condition |
| PLECplectin | Sometimes (5–29%) | In 1 condition |
| RAD51RAD51 recombinase | Sometimes (5–29%) | In 1 condition |
| RAD51CRAD51 paralog C | Sometimes (5–29%) | In 1 condition |
| RFWD3ring finger and WD repeat domain 3 | Sometimes (5–29%) | In 1 condition |
| ROR2ROR family WNT receptor 2 | Sometimes (5–29%) | In 1 condition |
| RPL10ribosomal protein L10 | Sometimes (5–29%) | In 1 condition |
| SALL1spalt like transcription factor 1 | Sometimes (5–29%) | In 1 condition |
| SALL4spalt like transcription factor 4 | Sometimes (5–29%) | In 1 condition |
| SIN3ASIN3 transcription regulator family member A | Sometimes (5–29%) | In 1 condition |
| SLX4SLX4 structure-specific endonuclease subunit | Sometimes (5–29%) | In 1 condition |
| TBX22T-box transcription factor 22 | Sometimes (5–29%) | In 1 condition |
| TFAP2Btranscription factor AP-2 beta | Sometimes (5–29%) | In 1 condition |
| TTC21Btetratricopeptide repeat domain 21B | Sometimes (5–29%) | In 1 condition |
| TWIST2twist family bHLH transcription factor 2 | Sometimes (5–29%) | In 2 conditions |
| UBA2ubiquitin like modifier activating enzyme 2 | Sometimes (5–29%) | In 1 condition |
| UBE2Tubiquitin conjugating enzyme E2 T | Sometimes (5–29%) | In 1 condition |
| WDR19WD repeat domain 19 | Sometimes (5–29%) | In 1 condition |
| XRCC2X-ray repair cross complementing 2 | Sometimes (5–29%) | In 1 condition |
| ZNF699zinc finger protein 699 | Sometimes (5–29%) | In 1 condition |
| CTCFCCCTC-binding factor | Rarely (1–4%) | In 1 condition |
| ARHGAP31Rho GTPase activating protein 31 | Not recorded | In 1 condition |
| ATP6V1B2ATPase H+ transporting V1 subunit B2 | Not recorded | In 1 condition |
| BMP4bone morphogenetic protein 4 | Not recorded | In 1 condition |
| EFNB1ephrin B1 | Not recorded | In 1 condition |
| FIG4FIG4 phosphoinositide 5-phosphatase | Not recorded | In 1 condition |
| FLNAfilamin A | Not recorded | In 2 conditions |
| KCNJ2potassium inwardly rectifying channel subfamily J member 2 | Not recorded | In 1 condition |
| PHGDHphosphoglycerate dehydrogenase | Not recorded | In 1 condition |
| PORCNporcupine O-acyltransferase | Not recorded | In 1 condition |
| SF3B4splicing factor 3b subunit 4 | Not recorded | In 1 condition |
| TBC1D32TBC1 domain family member 32 | Not recorded | In 1 condition |
| TCTN3tectonic family member 3 | Not recorded | In 1 condition |
| TWIST1twist family bHLH transcription factor 1 | Not recorded | In 1 condition |
| WNT10BWnt family member 10B | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
- Webbed 2nd and 3rd toes97 genes
- Webbed 4th-5th toes14 genes
- Webbed skin of toes12 genes
- Webbed 3rd-4th toes7 genes
- Webbed 2nd-4th toes5 genes
- Webbed 2nd-5th toes4 genes
- Webbed first and second toes4 genes
- Webbed 1st-3rd toes1 gene
- Webbed 1st-5th toes1 gene
- Webbed 3rd-5th toes1 gene
- Webbed first through fourth toes1 gene
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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