Trait
Sparse eyebrow
Decreased density/number of eyebrow hairs.
Summary
- Also called
- Sparse eyebrows, Hypotrichosis of eyebrow
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Sparse eyebrow, and the rest of your genome, with one test.
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Get my Genome Test151 genes linked to Sparse eyebrow
Changes in these genes cause rare conditions in which Sparse eyebrow is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ALX4ALX homeobox 4 | Always | In 1 condition |
| ANTXR1ANTXR cell adhesion molecule 1 | Always | In 2 conditions |
| BANF1barrier to autointegration nuclear assembly factor 1 | Always | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Always | In 1 condition |
| BRF1BRF1 general transcription factor IIIB subunit | Always | In 2 conditions |
| CILK1ciliogenesis associated kinase 1 | Always | In 1 condition |
| CLDN1claudin 1 | Always | In 2 conditions |
| CRIPTCXXC repeat containing interactor of PDZ3 domain | Always | In 1 condition |
| DLX4distal-less homeobox 4 | Always | In 1 condition |
| DNA2DNA replication helicase/nuclease 2 | Always | In 1 condition |
| DONSONDNA replication fork stabilization factor DONSON | Always | In 1 condition |
| DPH1diphthamide biosynthesis 1 | Always | In 2 conditions |
| DSC3desmocollin 3 | Always | In 1 condition |
| EDARectodysplasin A receptor | Always | In 2 conditions |
| EDARADDEDAR associated via death domain | Always | In 2 conditions |
| ELFN1extracellular leucine rich repeat and fibronectin type III domain containing 1 | Always | In 1 condition |
| FAM111BFAM111 trypsin like peptidase B | Always | In 1 condition |
| GJA1gap junction protein alpha 1 | Always | In 2 conditions |
| GJB2gap junction protein beta 2 | Always | In 3 conditions |
| GTPBP1GTP binding protein 1 | Always | In 1 condition |
| GTPBP2GTP binding protein 2 | Always | In 1 condition |
| HERC1HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | Always | In 2 conditions |
| HRURFHR upstream open reading frame | Always | In 1 condition |
| IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma | Always | In 2 conditions |
| IRX5iroquois homeobox 5 | Always | In 1 condition |
| ITGA3integrin subunit alpha 3 | Always | In 1 condition |
| ITPR3inositol 1,4,5-trisphosphate receptor type 3 | Always | In 1 condition |
| KANK2KN motif and ankyrin repeat domains 2 | Always | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Always | In 1 condition |
| KRT74keratin 74 | Always | In 1 condition |
| LIPHlipase H | Always | In 2 conditions |
| LRP1LDL receptor related protein 1 | Always | In 2 conditions |
| MAP2K1mitogen-activated protein kinase kinase 1 | Always | In 1 condition |
| MAP2K2mitogen-activated protein kinase kinase 2 | Always | In 1 condition |
| MARS1methionyl-tRNA synthetase 1 | Always | In 1 condition |
| MED12mediator complex subunit 12 | Always | In 1 condition |
| NSD1nuclear receptor binding SET domain protein 1 | Always | In 1 condition |
| PAN2poly(A) specific ribonuclease subunit PAN2 | Always | In 1 condition |
| PPP2R3Cprotein phosphatase 2 regulatory subunit B''gamma | Always | In 1 condition |
| PUM1pumilio RNA binding family member 1 | Always | In 1 condition |
Show 111 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| RIN2Ras and Rab interactor 2 | Always | In 1 condition |
| RNF113Aring finger protein 113A | Always | In 1 condition |
| RNU2-2RNA, U2 small nuclear 2 | Always | In 1 condition |
| SMSspermine synthase | Always | In 2 conditions |
| SONSON DNA and RNA binding protein | Always | In 2 conditions |
| SOS1SOS Ras/Rac guanine nucleotide exchange factor 1 | Always | In 1 condition |
| SPINK5serine peptidase inhibitor Kazal type 5 | Always | In 2 conditions |
| ST14ST14 transmembrane serine protease matriptase | Always | In 1 condition |
| SUPT7LSPT7 like, STAGA complex subunit gamma | Always | In 1 condition |
| TM2D3TM2 domain containing 3 | Always | In 1 condition |
| TP63tumor protein p63 | Always | In 4 conditions |
| UBE3Bubiquitin protein ligase E3B | Always | In 1 condition |
| WNT10BWnt family member 10B | Always | In 1 condition |
| YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta | Always | In 1 condition |
| ZMPSTE24zinc metallopeptidase STE24 | Always | In 2 conditions |
| APCDD1APC down-regulated 1 | Very often (80–99%) | In 1 condition |
| BRD4bromodomain containing 4 | Very often (80–99%) | In 1 condition |
| CHST3carbohydrate sulfotransferase 3 | Very often (80–99%) | In 2 conditions |
| DPH2diphthamide biosynthesis 2 | Very often (80–99%) | In 1 condition |
| DPH5diphthamide biosynthesis 5 | Very often (80–99%) | In 1 condition |
| DSG4desmoglein 4 | Very often (80–99%) | In 2 conditions |
| LMNAlamin A/C | Very often (80–99%) | In 1 condition |
| LPAR6lysophosphatidic acid receptor 6 | Very often (80–99%) | In 2 conditions |
| LSSlanosterol synthase | Very often (80–99%) | In 1 condition |
| MAB21L1mab-21 like 1 | Very often (80–99%) | In 1 condition |
| RMRPRNA component of mitochondrial RNA processing endoribonuclease | Very often (80–99%) | In 2 conditions |
| RPL21ribosomal protein L21 | Very often (80–99%) | In 1 condition |
| SNRPEsmall nuclear ribonucleoprotein polypeptide E | Very often (80–99%) | In 1 condition |
| SOS2SOS Ras/Rho guanine nucleotide exchange factor 2 | Very often (80–99%) | In 1 condition |
| TRPS1transcriptional repressor GATA binding 1 | Very often (80–99%) | In 1 condition |
| AARS1alanyl-tRNA synthetase 1 | Often (30–79%) | In 1 condition |
| ALX1ALX homeobox 1 | Often (30–79%) | In 1 condition |
| B4GALT7beta-1,4-galactosyltransferase 7 | Often (30–79%) | In 1 condition |
| CEP120centrosomal protein 120 | Often (30–79%) | In 1 condition |
| CHD6chromodomain helicase DNA binding protein 6 | Often (30–79%) | In 1 condition |
| DSPdesmoplakin | Often (30–79%) | In 1 condition |
| FIG4FIG4 phosphoinositide 5-phosphatase | Often (30–79%) | In 2 conditions |
| GJB6gap junction protein beta 6 | Often (30–79%) | In 3 conditions |
| HDAC4histone deacetylase 4 | Often (30–79%) | In 1 condition |
| KDM6Alysine demethylase 6A | Often (30–79%) | In 1 condition |
| KMT2Dlysine methyltransferase 2D | Often (30–79%) | In 2 conditions |
| LARP7La ribonucleoprotein 7, transcriptional regulator | Often (30–79%) | In 1 condition |
| LEF1lymphoid enhancer binding factor 1 | Often (30–79%) | In 1 condition |
| LGI1leucine rich glioma inactivated 1 | Often (30–79%) | In 1 condition |
| LZTR1leucine zipper like post translational regulator 1 | Often (30–79%) | In 2 conditions |
| MAN1B1mannosidase alpha class 1B member 1 | Often (30–79%) | In 2 conditions |
| MAPKAPK5MAPK activated protein kinase 5 | Often (30–79%) | In 1 condition |
| MBTPS2membrane bound transcription factor peptidase, site 2 | Often (30–79%) | In 2 conditions |
| MED25mediator complex subunit 25 | Often (30–79%) | In 1 condition |
| MTX2metaxin 2 | Often (30–79%) | In 1 condition |
| POGZpogo transposable element derived with ZNF domain | Often (30–79%) | In 1 condition |
| RAP1BRAP1B, member of RAS oncogene family | Often (30–79%) | In 1 condition |
| RECQL4RecQ like helicase 4 | Often (30–79%) | In 1 condition |
| RPS28ribosomal protein S28 | Often (30–79%) | In 1 condition |
| SAT1spermidine/spermine N1-acetyltransferase 1 | Often (30–79%) | In 1 condition |
| SMARCA2SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2 | Often (30–79%) | In 1 condition |
| SPOPspeckle type BTB/POZ protein | Often (30–79%) | In 1 condition |
| STAG2STAG2 cohesin complex component | Often (30–79%) | In 1 condition |
| USB1U6 snRNA biogenesis phosphodiesterase 1 | Often (30–79%) | In 1 condition |
| VAC14VAC14 component of PIKFYVE complex | Often (30–79%) | In 1 condition |
| WLSWnt ligand secretion mediator | Often (30–79%) | In 1 condition |
| WNT10AWnt family member 10A | Often (30–79%) | In 2 conditions |
| BCL11ABCL11 transcription factor A | Sometimes (5–29%) | In 1 condition |
| CDC42cell division cycle 42 | Sometimes (5–29%) | In 2 conditions |
| CDC42BPBCDC42 binding protein kinase beta | Sometimes (5–29%) | In 1 condition |
| CNTNAP2contactin associated protein 2 | Sometimes (5–29%) | In 1 condition |
| COL11A1collagen type XI alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| CWC27CWC27 spliceosome associated cyclophilin | Sometimes (5–29%) | In 1 condition |
| DDX3XDEAD-box helicase 3 X-linked | Sometimes (5–29%) | In 1 condition |
| DOLKdolichol kinase | Sometimes (5–29%) | In 1 condition |
| EBPEBP cholestenol delta-isomerase | Sometimes (5–29%) | In 2 conditions |
| FBXO11F-box protein 11 | Sometimes (5–29%) | In 1 condition |
| GAD1glutamate decarboxylase 1 | Sometimes (5–29%) | In 1 condition |
| H3-3AH3.3 histone A | Sometimes (5–29%) | In 1 condition |
| JARID2jumonji and AT-rich interaction domain containing 2 | Sometimes (5–29%) | In 1 condition |
| KDM1Alysine demethylase 1A | Sometimes (5–29%) | In 1 condition |
| KIFBPkinesin family binding protein | Sometimes (5–29%) | In 1 condition |
| LTV1LTV1 ribosome biogenesis factor | Sometimes (5–29%) | In 1 condition |
| MED12Lmediator complex subunit 12L | Sometimes (5–29%) | In 1 condition |
| MED16mediator complex subunit 16 | Sometimes (5–29%) | In 1 condition |
| MEGF8multiple EGF like domains 8 | Sometimes (5–29%) | In 1 condition |
| NF1neurofibromin 1 | Sometimes (5–29%) | In 1 condition |
| NFIBnuclear factor I B | Sometimes (5–29%) | In 1 condition |
| ODC1ornithine decarboxylase 1 | Sometimes (5–29%) | In 1 condition |
| RAF1Raf-1 proto-oncogene, serine/threonine kinase | Sometimes (5–29%) | In 1 condition |
| RELREL proto-oncogene, NF-kB subunit | Sometimes (5–29%) | In 1 condition |
| RHOBTB2Rho related BTB domain containing 2 | Sometimes (5–29%) | In 1 condition |
| SPRED2sprouty related EVH1 domain containing 2 | Sometimes (5–29%) | In 1 condition |
| TBCDtubulin folding cofactor D | Sometimes (5–29%) | In 2 conditions |
| TMEM147transmembrane protein 147 | Sometimes (5–29%) | In 1 condition |
| TWIST2twist family bHLH transcription factor 2 | Sometimes (5–29%) | In 1 condition |
| XPO1exportin 1 | Sometimes (5–29%) | In 1 condition |
| YY1YY1 transcription factor | Sometimes (5–29%) | In 2 conditions |
| CTCFCCCTC-binding factor | Rarely (1–4%) | In 1 condition |
| MARK2microtubule affinity regulating kinase 2 | Rarely (1–4%) | In 1 condition |
| ATAD3AATPase family AAA domain containing 3A | Not recorded | In 1 condition |
| CDH3cadherin 3 | Not recorded | In 1 condition |
| EDAectodysplasin A | Not recorded | In 1 condition |
| GNPTABN-acetylglucosamine-1-phosphate transferase subunits alpha and beta | Not recorded | In 1 condition |
| HECW2HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 | Not recorded | In 1 condition |
| JUPjunction plakoglobin | Not recorded | In 1 condition |
| KRT17keratin 17 | Not recorded | In 1 condition |
| KRT6Bkeratin 6B | Not recorded | In 1 condition |
| MEIS2Meis homeobox 2 | Not recorded | In 1 condition |
| NAA10N-alpha-acetyltransferase 10, NatA catalytic subunit | Not recorded | In 1 condition |
| NECTIN1nectin cell adhesion molecule 1 | Not recorded | In 1 condition |
| POLR3ARNA polymerase III subunit A | Not recorded | In 1 condition |
| RNU12RNA, U12 small nuclear | Not recorded | In 1 condition |
| RNU4ATACRNA, U4atac small nuclear | Not recorded | In 1 condition |
| THUMPD1THUMP domain 1 NAT10 acetyltransferase adaptor | Not recorded | In 1 condition |
| WDR35WD repeat domain 35 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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