Trait
Absence of tears in the eyes
Clinical name: Alacrima
The complete absence of aqueous tear production. Typically, this is clinically measured by a Schirmer I test result of 0 millimeters of wetting on the filter paper strip after 5 minutes.
Summary
- Also called
- Absent tear secretion, 0 mm wetting on Schirmer I test, Absent lacrimal fluids, Absent lacrimation on Schirmer I test, Absent tear flow on Schirmer I test, Absolute aqueous tear deficiency on Schirmer I test
- Body system
- Abnormality of the eye
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test19 genes linked to Absence of tears in the eyes
Changes in these genes cause rare conditions in which Absence of tears in the eyes is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AAASaladin WD repeat nucleoporin | Always | In 2 conditions |
| CLDN10claudin 10 | Always | In 1 condition |
| FGF10fibroblast growth factor 10 | Always | In 1 condition |
| FGFR3fibroblast growth factor receptor 3 | Always | In 1 condition |
| GMPPAGDP-mannose pyrophosphorylase A | Always | In 2 conditions |
| NDC1NDC1 transmembrane nucleoporin | Always | In 1 condition |
| PAX1paired box 1 | Always | In 1 condition |
| PIGQphosphatidylinositol glycan anchor biosynthesis class Q | Always | In 1 condition |
| SLC12A2solute carrier family 12 member 2 | Always | In 1 condition |
| SOX10SRY-box transcription factor 10 | Always | In 1 condition |
| TP63tumor protein p63 | Always | In 1 condition |
| ELP1elongator acetyltransferase complex subunit 1 | Very often (80–99%) | In 2 conditions |
| NGLY1N-glycanase 1 | Very often (80–99%) | In 2 conditions |
| TRAPPC11trafficking protein particle complex subunit 11 | Very often (80–99%) | In 2 conditions |
| DSTdystonin | Often (30–79%) | In 1 condition |
| FGFR2fibroblast growth factor receptor 2 | Often (30–79%) | In 1 condition |
| MADDMAP kinase activating death domain | Often (30–79%) | In 2 conditions |
| MRAPmelanocortin 2 receptor accessory protein | Often (30–79%) | In 1 condition |
| SETBP1SET binding protein 1 | Sometimes (5–29%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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