Trait
Thickening of palms and soles
Clinical name: Palmoplantar keratoderma
Abnormal thickening of the skin of the palms of the hands and the soles of the feet.
Summary
- Also called
- Keratoderma, Palmar and plantar keratoderma
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Thickening of palms and soles, and the rest of your genome, with one test.
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Get my Genome Test107 genes linked to Thickening of palms and soles
Changes in these genes cause rare conditions in which Thickening of palms and soles is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| DSG1desmoglein 1 | Always | In 3 conditions |
| DSPdesmoplakin | Always | In 4 conditions |
| ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 1 | Always | In 1 condition |
| GJA1gap junction protein alpha 1 | Always | In 4 conditions |
| GJB2gap junction protein beta 2 | Always | In 5 conditions |
| GRHL2grainyhead like transcription factor 2 | Always | In 1 condition |
| JUPjunction plakoglobin | Always | In 2 conditions |
| KANK2KN motif and ankyrin repeat domains 2 | Always | In 1 condition |
| KRT1keratin 1 | Always | In 5 conditions |
| KRT16keratin 16 | Always | In 2 conditions |
| NIPAL4NIPA like domain containing 4 | Always | In 3 conditions |
| NLRP1NLR family pyrin domain containing 1 | Always | In 1 condition |
| PERPp53 apoptosis effector related to PMP22 | Always | In 2 conditions |
| PNPLA1patatin like domain 1, omega-hydroxyceramide transacylase | Always | In 2 conditions |
| SNAP29synaptosome associated protein 29 | Always | In 1 condition |
| TP63tumor protein p63 | Always | In 2 conditions |
| TRPV3transient receptor potential cation channel subfamily V member 3 | Always | In 2 conditions |
| USB1U6 snRNA biogenesis phosphodiesterase 1 | Always | In 2 conditions |
| WNT10AWnt family member 10A | Always | In 2 conditions |
| AAGABalpha and gamma adaptin binding protein | Very often (80–99%) | In 1 condition |
| ABCA12ATP binding cassette subfamily A member 12 | Very often (80–99%) | In 3 conditions |
| ALOX12Barachidonate 12-lipoxygenase, 12R type | Very often (80–99%) | In 3 conditions |
| ALOXE3arachidonate epidermal lipoxygenase 3 | Very often (80–99%) | In 4 conditions |
| ASPRV1aspartic peptidase retroviral like 1 | Very often (80–99%) | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Very often (80–99%) | In 1 condition |
| CARD14caspase recruitment domain family member 14 | Very often (80–99%) | In 2 conditions |
| CFTRCF transmembrane conductance regulator | Very often (80–99%) | In 1 condition |
| COL14A1collagen type XIV alpha 1 chain | Very often (80–99%) | In 1 condition |
| CTSCcathepsin C | Very often (80–99%) | In 2 conditions |
| CYP4F22cytochrome P450 family 4 subfamily F member 22 | Very often (80–99%) | In 2 conditions |
| FERMT1FERM domain containing kindlin 1 | Very often (80–99%) | In 1 condition |
| FGFR2fibroblast growth factor receptor 2 | Very often (80–99%) | In 1 condition |
| KDSR3-ketodihydrosphingosine reductase | Very often (80–99%) | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Very often (80–99%) | In 1 condition |
| KRT14keratin 14 | Very often (80–99%) | In 2 conditions |
| KRT17keratin 17 | Very often (80–99%) | In 1 condition |
| KRT2keratin 2 | Very often (80–99%) | In 1 condition |
| KRT5keratin 5 | Very often (80–99%) | In 1 condition |
| KRT6Akeratin 6A | Very often (80–99%) | In 2 conditions |
| KRT6Bkeratin 6B | Very often (80–99%) | In 2 conditions |
Show 67 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| KRT83keratin 83 | Very often (80–99%) | In 1 condition |
| LIPNlipase family member N | Very often (80–99%) | In 1 condition |
| LORICRINloricrin cornified envelope precursor protein | Very often (80–99%) | In 2 conditions |
| LSSlanosterol synthase | Very often (80–99%) | In 1 condition |
| MAP2K1mitogen-activated protein kinase kinase 1 | Very often (80–99%) | In 1 condition |
| MAP2K2mitogen-activated protein kinase kinase 2 | Very often (80–99%) | In 1 condition |
| MBTPS2membrane bound transcription factor peptidase, site 2 | Very often (80–99%) | In 4 conditions |
| MT-TS1mitochondrially encoded tRNA-Ser (UCN) 1 | Very often (80–99%) | In 1 condition |
| PEPDpeptidase D | Very often (80–99%) | In 1 condition |
| PKP1plakophilin 1 | Very often (80–99%) | In 1 condition |
| POMPproteasome maturation protein | Very often (80–99%) | In 1 condition |
| PTENphosphatase and tensin homolog | Very often (80–99%) | In 1 condition |
| RHBDF2rhomboid 5 homolog 2 | Very often (80–99%) | In 1 condition |
| RSPO1R-spondin 1 | Very often (80–99%) | In 2 conditions |
| SDR9C7short chain dehydrogenase/reductase family 9C member 7 | Very often (80–99%) | In 2 conditions |
| SERPINB7serpin family B member 7 | Very often (80–99%) | In 1 condition |
| SLURP1secreted LY6/PLAUR domain containing 1 | Very often (80–99%) | In 1 condition |
| SMARCAD1SNF2 related chromatin remodeling ATPase with DExD box 1 | Very often (80–99%) | In 2 conditions |
| SULT2B1sulfotransferase family 2B member 1 | Very often (80–99%) | In 2 conditions |
| TATtyrosine aminotransferase | Very often (80–99%) | In 1 condition |
| TGM1transglutaminase 1 | Very often (80–99%) | In 2 conditions |
| TRPM4transient receptor potential cation channel subfamily M member 4 | Very often (80–99%) | In 1 condition |
| AAASaladin WD repeat nucleoporin | Often (30–79%) | In 1 condition |
| AP1B1adaptor related protein complex 1 subunit beta 1 | Often (30–79%) | In 1 condition |
| ATP2A2ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 | Often (30–79%) | In 1 condition |
| CD28CD28 molecule | Often (30–79%) | In 1 condition |
| CERS3ceramide synthase 3 | Often (30–79%) | In 1 condition |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Often (30–79%) | In 1 condition |
| GJB6gap junction protein beta 6 | Often (30–79%) | In 2 conditions |
| GMPPAGDP-mannose pyrophosphorylase A | Often (30–79%) | In 1 condition |
| KRT10keratin 10 | Often (30–79%) | In 2 conditions |
| PLECplectin | Often (30–79%) | In 1 condition |
| PORCNporcupine O-acyltransferase | Often (30–79%) | In 1 condition |
| SASH1SAM and SH3 domain containing 1 | Often (30–79%) | In 1 condition |
| TNFRSF1BTNF receptor superfamily member 1B | Often (30–79%) | In 1 condition |
| TRAPPC11trafficking protein particle complex subunit 11 | Often (30–79%) | In 1 condition |
| ACDACD shelterin complex subunit and telomerase recruitment factor | Sometimes (5–29%) | In 1 condition |
| COL17A1collagen type XVII alpha 1 chain | Sometimes (5–29%) | In 2 conditions |
| CTC1CST telomere replication complex component 1 | Sometimes (5–29%) | In 1 condition |
| DKC1dyskerin pseudouridine synthase 1 | Sometimes (5–29%) | In 1 condition |
| HPGD15-hydroxyprostaglandin dehydrogenase | Sometimes (5–29%) | In 1 condition |
| ITGB4integrin subunit beta 4 | Sometimes (5–29%) | In 1 condition |
| LAMA3laminin subunit alpha 3 | Sometimes (5–29%) | In 1 condition |
| LAMB3laminin subunit beta 3 | Sometimes (5–29%) | In 1 condition |
| LAMC2laminin subunit gamma 2 | Sometimes (5–29%) | In 1 condition |
| LRP1LDL receptor related protein 1 | Sometimes (5–29%) | In 1 condition |
| MCOLN1mucolipin TRP cation channel 1 | Sometimes (5–29%) | In 1 condition |
| NHP2NHP2 ribonucleoprotein | Sometimes (5–29%) | In 1 condition |
| NOP10NOP10 ribonucleoprotein | Sometimes (5–29%) | In 1 condition |
| NPM1nucleophosmin 1 | Sometimes (5–29%) | In 1 condition |
| PARNpoly(A)-specific ribonuclease | Sometimes (5–29%) | In 1 condition |
| RTEL1regulator of telomere elongation helicase 1 | Sometimes (5–29%) | In 1 condition |
| SAT1spermidine/spermine N1-acetyltransferase 1 | Sometimes (5–29%) | In 1 condition |
| SLCO2A1solute carrier organic anion transporter family member 2A1 | Sometimes (5–29%) | In 1 condition |
| SRD5A3steroid 5 alpha-reductase 3 | Sometimes (5–29%) | In 1 condition |
| STSsteroid sulfatase | Sometimes (5–29%) | In 1 condition |
| TERCtelomerase RNA component | Sometimes (5–29%) | In 1 condition |
| TERTtelomerase reverse transcriptase | Sometimes (5–29%) | In 1 condition |
| TINF2TERF1 interacting nuclear factor 2 | Sometimes (5–29%) | In 1 condition |
| TYMSthymidylate synthetase | Sometimes (5–29%) | In 1 condition |
| WRAP53WD repeat containing antisense to TP53 | Sometimes (5–29%) | In 1 condition |
| COL7A1collagen type VII alpha 1 chain | Not recorded | In 4 conditions |
| CSTAcystatin A | Not recorded | In 1 condition |
| DSC2desmocollin 2 | Not recorded | In 1 condition |
| KLK11kallikrein related peptidase 11 | Not recorded | In 1 condition |
| KRT6Ckeratin 6C | Not recorded | In 1 condition |
| MMP1matrix metallopeptidase 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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