Trait
Dental cavities
Clinical name: Carious teeth
Caries is a multifactorial bacterial infection affecting the structure of the tooth. This term has been used to describe the presence of more than expected dental caries.
Summary
- Also called
- Dental decay, Rotting teeth, Tooth cavities, Tooth decay, Caries, Cariosity of teeth, Dental caries, Early dental caries, Frequent caries
- Body system
- Abnormality of head or neck
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test171 genes linked to Dental cavities
Changes in these genes cause rare conditions in which Dental cavities is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AP3B1adaptor related protein complex 3 subunit beta 1 | Always | In 1 condition |
| COL17A1collagen type XVII alpha 1 chain | Always | In 3 conditions |
| FGF10fibroblast growth factor 10 | Always | In 3 conditions |
| FGFR3fibroblast growth factor receptor 3 | Always | In 2 conditions |
| IFT52intraflagellar transport 52 | Always | In 1 condition |
| IKZF2IKAROS family zinc finger 2 | Always | In 1 condition |
| LAMB3laminin subunit beta 3 | Always | In 2 conditions |
| LIFRLIF receptor subunit alpha | Always | In 1 condition |
| PAX1paired box 1 | Always | In 1 condition |
| RBM28RNA binding motif protein 28 | Always | In 2 conditions |
| RBSNrabenosyn, RAB effector | Always | In 1 condition |
| SEC23ASEC23 homolog A, COPII component | Always | In 2 conditions |
| SLC24A4solute carrier family 24 member 4 | Always | In 1 condition |
| THOC6THO complex subunit 6 | Always | In 2 conditions |
| TP63tumor protein p63 | Always | In 3 conditions |
| USB1U6 snRNA biogenesis phosphodiesterase 1 | Always | In 2 conditions |
| ATP6V0A2ATPase H+ transporting V0 subunit a2 | Very often (80–99%) | In 4 conditions |
| ATP6V1AATPase H+ transporting V1 subunit A | Very often (80–99%) | In 1 condition |
| ATP6V1E1ATPase H+ transporting V1 subunit E1 | Very often (80–99%) | In 1 condition |
| CDH11cadherin 11 | Very often (80–99%) | In 1 condition |
| CNNM4cyclin and CBS domain divalent metal cation transport mediator 4 | Very often (80–99%) | In 1 condition |
| COL7A1collagen type VII alpha 1 chain | Very often (80–99%) | In 5 conditions |
| FGF3fibroblast growth factor 3 | Very often (80–99%) | In 1 condition |
| GJA1gap junction protein alpha 1 | Very often (80–99%) | In 2 conditions |
| IFIH1interferon induced with helicase C domain 1 | Very often (80–99%) | In 1 condition |
| MMP1matrix metallopeptidase 1 | Very often (80–99%) | In 1 condition |
| PEPDpeptidase D | Very often (80–99%) | In 1 condition |
| RUNX2RUNX family transcription factor 2 | Very often (80–99%) | In 1 condition |
| ACDACD shelterin complex subunit and telomerase recruitment factor | Often (30–79%) | In 1 condition |
| AGAaspartylglucosaminidase | Often (30–79%) | In 1 condition |
| ARSBarylsulfatase B | Often (30–79%) | In 1 condition |
| ARVCFARVCF delta catenin family member | Often (30–79%) | In 1 condition |
| ATRATR checkpoint kinase | Often (30–79%) | In 1 condition |
| CAV1caveolin 1 | Often (30–79%) | In 1 condition |
| CCN2cellular communication network factor 2 | Often (30–79%) | In 1 condition |
| CCR6C-C motif chemokine receptor 6 | Often (30–79%) | In 1 condition |
| CDH1cadherin 1 | Often (30–79%) | In 1 condition |
| CDH3cadherin 3 | Often (30–79%) | In 1 condition |
| COG6component of oligomeric golgi complex 6 | Often (30–79%) | In 2 conditions |
| COMTcatechol-O-methyltransferase | Often (30–79%) | In 1 condition |
Show 131 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| COX4I2cytochrome c oxidase subunit 4I2 | Often (30–79%) | In 1 condition |
| CTC1CST telomere replication complex component 1 | Often (30–79%) | In 1 condition |
| CTNND1catenin delta 1 | Often (30–79%) | In 1 condition |
| CTSCcathepsin C | Often (30–79%) | In 1 condition |
| DKC1dyskerin pseudouridine synthase 1 | Often (30–79%) | In 2 conditions |
| DPH5diphthamide biosynthesis 5 | Often (30–79%) | In 1 condition |
| EP300EP300 lysine acetyltransferase | Often (30–79%) | In 2 conditions |
| ERCC6ERCC excision repair 6, chromatin remodeling factor | Often (30–79%) | In 3 conditions |
| ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit | Often (30–79%) | In 2 conditions |
| FAM111AFAM111 trypsin like peptidase A | Often (30–79%) | In 1 condition |
| FERMT1FERM domain containing kindlin 1 | Often (30–79%) | In 2 conditions |
| FGFR2fibroblast growth factor receptor 2 | Often (30–79%) | In 2 conditions |
| GP1BBglycoprotein Ib platelet subunit beta | Often (30–79%) | In 1 condition |
| GTF2H5general transcription factor IIH subunit 5 | Often (30–79%) | In 2 conditions |
| HIRAhistone cell cycle regulator | Often (30–79%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Often (30–79%) | In 1 condition |
| IRF5interferon regulatory factor 5 | Often (30–79%) | In 1 condition |
| JMJD1Cjumonji domain containing 1C | Often (30–79%) | In 1 condition |
| LAMA3laminin subunit alpha 3 | Often (30–79%) | In 2 conditions |
| MBTPS2membrane bound transcription factor peptidase, site 2 | Often (30–79%) | In 1 condition |
| MMP13matrix metallopeptidase 13 | Often (30–79%) | In 1 condition |
| NECTIN1nectin cell adhesion molecule 1 | Often (30–79%) | In 1 condition |
| NHP2NHP2 ribonucleoprotein | Often (30–79%) | In 2 conditions |
| NOP10NOP10 ribonucleoprotein | Often (30–79%) | In 2 conditions |
| NPM1nucleophosmin 1 | Often (30–79%) | In 1 condition |
| PARNpoly(A)-specific ribonuclease | Often (30–79%) | In 2 conditions |
| PERPp53 apoptosis effector related to PMP22 | Often (30–79%) | In 1 condition |
| PGM2L1phosphoglucomutase 2 like 1 | Often (30–79%) | In 1 condition |
| RREB1ras responsive element binding protein 1 | Often (30–79%) | In 1 condition |
| RTEL1regulator of telomere elongation helicase 1 | Often (30–79%) | In 1 condition |
| SEC24CSEC24 homolog C, COPII component | Often (30–79%) | In 1 condition |
| SFRP4secreted frizzled related protein 4 | Often (30–79%) | In 2 conditions |
| SLC10A7solute carrier family 10 member 7 | Often (30–79%) | In 1 condition |
| SRCAPSnf2 related CREBBP activator protein | Often (30–79%) | In 2 conditions |
| TBCEtubulin folding cofactor E | Often (30–79%) | In 2 conditions |
| TBX1T-box transcription factor 1 | Often (30–79%) | In 1 condition |
| TERCtelomerase RNA component | Often (30–79%) | In 2 conditions |
| TERTtelomerase reverse transcriptase | Often (30–79%) | In 2 conditions |
| TINF2TERF1 interacting nuclear factor 2 | Often (30–79%) | In 2 conditions |
| TRPV3transient receptor potential cation channel subfamily V member 3 | Often (30–79%) | In 1 condition |
| TYMSthymidylate synthetase | Often (30–79%) | In 1 condition |
| UFD1ubiquitin recognition factor in ER associated degradation 1 | Often (30–79%) | In 1 condition |
| WRAP53WD repeat containing antisense to TP53 | Often (30–79%) | In 1 condition |
| AARS1alanyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| ABL1ABL proto-oncogene 1, non-receptor tyrosine kinase | Sometimes (5–29%) | In 1 condition |
| ADNPactivity dependent neuroprotector homeobox | Sometimes (5–29%) | In 1 condition |
| AKT1AKT serine/threonine kinase 1 | Sometimes (5–29%) | In 1 condition |
| ANAPC1anaphase promoting complex subunit 1 | Sometimes (5–29%) | In 1 condition |
| APCAPC regulator of Wnt signaling pathway | Sometimes (5–29%) | In 1 condition |
| ASLargininosuccinate lyase | Sometimes (5–29%) | In 1 condition |
| B3GALT6beta-1,3-galactosyltransferase 6 | Sometimes (5–29%) | In 1 condition |
| BAZ1Bbromodomain adjacent to zinc finger domain 1B | Sometimes (5–29%) | In 1 condition |
| BUD23BUD23 rRNA methyltransferase and ribosome maturation factor | Sometimes (5–29%) | In 1 condition |
| CARS1cysteinyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| CLCN7Cl-/H+ antiporter 7 | Sometimes (5–29%) | In 1 condition |
| CLIP2CAP-Gly domain containing linker protein 2 | Sometimes (5–29%) | In 1 condition |
| COL2A1collagen type II alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| CREBBPCREB binding lysine acetyltransferase | Sometimes (5–29%) | In 2 conditions |
| CTSKcathepsin K | Sometimes (5–29%) | In 2 conditions |
| DBR1debranching RNA lariats 1 | Sometimes (5–29%) | In 1 condition |
| DNAJC21DnaJ heat shock protein family (Hsp40) member C21 | Sometimes (5–29%) | In 1 condition |
| DNAJC30DnaJ heat shock protein family (Hsp40) member C30 | Sometimes (5–29%) | In 1 condition |
| EFL1elongation factor like GTPase 1 | Sometimes (5–29%) | In 1 condition |
| EIF4Heukaryotic translation initiation factor 4H | Sometimes (5–29%) | In 1 condition |
| ELNelastin | Sometimes (5–29%) | In 1 condition |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Sometimes (5–29%) | In 1 condition |
| ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit | Sometimes (5–29%) | In 1 condition |
| FKBP6FKBP prolyl isomerase family member 6 (inactive) | Sometimes (5–29%) | In 1 condition |
| GTF2E2general transcription factor IIE subunit 2 | Sometimes (5–29%) | In 1 condition |
| GTF2Igeneral transcription factor IIi | Sometimes (5–29%) | In 1 condition |
| GTF2IRD1GTF2I repeat domain containing 1 | Sometimes (5–29%) | In 1 condition |
| GTF2IRD2GTF2I repeat domain containing 2 | Sometimes (5–29%) | In 1 condition |
| HERC2HECT and RLD domain containing E3 ubiquitin protein ligase 2 | Sometimes (5–29%) | In 1 condition |
| KDM5Alysine demethylase 5A | Sometimes (5–29%) | In 1 condition |
| KMT2Dlysine methyltransferase 2D | Sometimes (5–29%) | In 1 condition |
| KRT14keratin 14 | Sometimes (5–29%) | In 2 conditions |
| LIMK1LIM domain kinase 1 | Sometimes (5–29%) | In 1 condition |
| MAGEL2MAGE family member L2 | Sometimes (5–29%) | In 1 condition |
| MEGF8multiple EGF like domains 8 | Sometimes (5–29%) | In 1 condition |
| METTL27methyltransferase like 27 | Sometimes (5–29%) | In 1 condition |
| MKRN3makorin ring finger protein 3 | Sometimes (5–29%) | In 1 condition |
| MPLKIPM-phase specific PLK1 interacting protein | Sometimes (5–29%) | In 1 condition |
| NCF1neutrophil cytosolic factor 1 | Sometimes (5–29%) | In 1 condition |
| NPAP1nuclear pore associated protein 1 | Sometimes (5–29%) | In 1 condition |
| OCRLOCRL inositol polyphosphate-5-phosphatase | Sometimes (5–29%) | In 1 condition |
| PKP1plakophilin 1 | Sometimes (5–29%) | In 1 condition |
| PPP1CBprotein phosphatase 1 catalytic subunit beta | Sometimes (5–29%) | In 1 condition |
| PTCH1patched 1 | Sometimes (5–29%) | In 1 condition |
| PTCH2patched 2 | Sometimes (5–29%) | In 1 condition |
| PWAR1Prader Willi/Angelman region RNA 1 | Sometimes (5–29%) | In 1 condition |
| PWRN1Prader-Willi region non-protein coding RNA 1 | Sometimes (5–29%) | In 1 condition |
| RECQL4RecQ like helicase 4 | Sometimes (5–29%) | In 1 condition |
| RFC2replication factor C subunit 2 | Sometimes (5–29%) | In 1 condition |
| RNF113Aring finger protein 113A | Sometimes (5–29%) | In 1 condition |
| SATB1SATB homeobox 1 | Sometimes (5–29%) | In 1 condition |
| SBDSSBDS ribosome maturation factor | Sometimes (5–29%) | In 1 condition |
| SCNM1sodium channel modifier 1 | Sometimes (5–29%) | In 1 condition |
| SHOC2SHOC2 leucine rich repeat scaffold protein | Sometimes (5–29%) | In 1 condition |
| SLC19A1solute carrier family 19 member 1 | Sometimes (5–29%) | In 1 condition |
| SLC37A4solute carrier family 37 member 4 | Sometimes (5–29%) | In 1 condition |
| SLF2SMC5/6 complex localization factor 2 | Sometimes (5–29%) | In 1 condition |
| SNORD115-1small nucleolar RNA, C/D box 115-1 | Sometimes (5–29%) | In 1 condition |
| SNORD116-1small nucleolar RNA, C/D box 116-1 | Sometimes (5–29%) | In 1 condition |
| SNRPBsmall nuclear ribonucleoprotein polypeptides B and B1 | Sometimes (5–29%) | In 1 condition |
| SNRPNsmall nuclear ribonucleoprotein polypeptide N | Sometimes (5–29%) | In 1 condition |
| SOX9SRY-box transcription factor 9 | Sometimes (5–29%) | In 1 condition |
| STX1Asyntaxin 1A | Sometimes (5–29%) | In 1 condition |
| SUFUSUFU negative regulator of hedgehog signaling | Sometimes (5–29%) | In 1 condition |
| TARS1threonyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| TBL2transducin beta like 2 | Sometimes (5–29%) | In 1 condition |
| TGFB1transforming growth factor beta 1 | Sometimes (5–29%) | In 2 conditions |
| TMEM270transmembrane protein 270 | Sometimes (5–29%) | In 1 condition |
| VPS37DVPS37D subunit of ESCRT-I | Sometimes (5–29%) | In 1 condition |
| ZMYM2zinc finger MYM-type containing 2 | Sometimes (5–29%) | In 1 condition |
| ALDH3A2aldehyde dehydrogenase 3 family member A2 | Rarely (1–4%) | In 1 condition |
| ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 1 | Rarely (1–4%) | In 1 condition |
| ALPLalkaline phosphatase, biomineralization associated | Not recorded | In 2 conditions |
| CRLF1cytokine receptor like factor 1 | Not recorded | In 1 condition |
| GALNSgalactosamine (N-acetyl)-6-sulfatase | Not recorded | In 1 condition |
| GLB1galactosidase beta 1 | Not recorded | In 1 condition |
| KLK4kallikrein related peptidase 4 | Not recorded | In 1 condition |
| LAMC2laminin subunit gamma 2 | Not recorded | In 1 condition |
| MAPRE2microtubule associated protein RP/EB family member 2 | Not recorded | In 1 condition |
| OFD1OFD1 centriole and centriolar satellite protein | Not recorded | In 1 condition |
| PLECplectin | Not recorded | In 1 condition |
| SGMS2sphingomyelin synthase 2 | Not recorded | In 1 condition |
| TCIRG1T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 | Not recorded | In 1 condition |
| TNFSF11TNF superfamily member 11 | Not recorded | In 1 condition |
| TRPS1transcriptional repressor GATA binding 1 | Not recorded | In 1 condition |
| UBE3Bubiquitin protein ligase E3B | Not recorded | In 1 condition |
| VDRvitamin D receptor | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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