Trait
Small nipples
Clinical name: Hypoplastic nipples
Underdevelopment of the nipple.
Summary
- Also called
- Nipple hypoplasia
- Body system
- Abnormality of the breast
Reference genomeGRCh38hg38
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Get my Genome Test43 genes linked to Small nipples
Changes in these genes cause rare conditions in which Small nipples is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CCDC47coiled-coil domain containing 47 | Always | In 1 condition |
| FAT4FAT atypical cadherin 4 | Always | In 1 condition |
| FIG4FIG4 phosphoinositide 5-phosphatase | Always | In 1 condition |
| KDM6Blysine demethylase 6B | Always | In 1 condition |
| TBX3T-box transcription factor 3 | Always | In 2 conditions |
| TP63tumor protein p63 | Always | In 5 conditions |
| KRT10keratin 10 | Very often (80–99%) | In 1 condition |
| BRD4bromodomain containing 4 | Often (30–79%) | In 1 condition |
| HDAC8histone deacetylase 8 | Often (30–79%) | In 1 condition |
| KDM6Alysine demethylase 6A | Often (30–79%) | In 1 condition |
| KMT2Dlysine methyltransferase 2D | Often (30–79%) | In 2 conditions |
| LEF1lymphoid enhancer binding factor 1 | Often (30–79%) | In 1 condition |
| MAU2MAU2 sister chromatid cohesion factor | Often (30–79%) | In 1 condition |
| NIPBLNIPBL cohesin loading factor | Often (30–79%) | In 2 conditions |
| NKX2-5NK2 homeobox 5 | Often (30–79%) | In 1 condition |
| NSD1nuclear receptor binding SET domain protein 1 | Often (30–79%) | In 1 condition |
| PTPRFprotein tyrosine phosphatase receptor type F | Often (30–79%) | In 1 condition |
| RAD21RAD21 cohesin complex component | Often (30–79%) | In 1 condition |
| SMC1Astructural maintenance of chromosomes 1A | Often (30–79%) | In 1 condition |
| SMC3structural maintenance of chromosomes 3 | Often (30–79%) | In 1 condition |
| TWIST2twist family bHLH transcription factor 2 | Often (30–79%) | In 3 conditions |
| ALG9ALG9 alpha-1,2-mannosyltransferase | Sometimes (5–29%) | In 1 condition |
| DLK1delta like non-canonical Notch ligand 1 | Sometimes (5–29%) | In 1 condition |
| KIF15kinesin family member 15 | Sometimes (5–29%) | In 1 condition |
| MEG3maternally expressed 3 | Sometimes (5–29%) | In 1 condition |
| MEGF8multiple EGF like domains 8 | Sometimes (5–29%) | In 1 condition |
| MGAT2alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | Sometimes (5–29%) | In 1 condition |
| PEX2peroxisomal biogenesis factor 2 | Sometimes (5–29%) | In 1 condition |
| RTL1retrotransposon Gag like 1 | Sometimes (5–29%) | In 1 condition |
| USP9Xubiquitin specific peptidase 9 X-linked | Sometimes (5–29%) | In 1 condition |
| ANTXR1ANTXR cell adhesion molecule 1 | Not recorded | In 1 condition |
| CHRNGcholinergic receptor nicotinic gamma subunit | Not recorded | In 1 condition |
| EDAectodysplasin A | Not recorded | In 1 condition |
| EDARADDEDAR associated via death domain | Not recorded | In 1 condition |
| GNEglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | Not recorded | In 1 condition |
| IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma | Not recorded | In 1 condition |
| PIGLphosphatidylinositol glycan anchor biosynthesis class L | Not recorded | In 1 condition |
| PORCNporcupine O-acyltransferase | Not recorded | In 1 condition |
| SETBP1SET binding protein 1 | Not recorded | In 1 condition |
| SLC25A24solute carrier family 25 member 24 | Not recorded | In 1 condition |
Show 3 more genes
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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