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Trait
Eczema
Clinical name: Eczematoid dermatitis
Eczema is a form of dermatitis that is characterized by scaly, pruritic, erythematous lesions located on flexural surfaces.
Summary
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This page as data
Add .json to the page's address, or ask for application/json, to read it as JSON.
library(jsonlite)
url <- "https://dantelabs.com/traits/eczematoid-dermatitis.json"
page <- fromJSON(url)
page$trait$nameEczemaHP:0000964
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Get my Genome Test149 genes linked to Eczema
Changes in these genes cause rare conditions in which Eczema is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CASP8caspase 8 | Always | In 1 condition |
| CST6cystatin E/M | Always | In 1 condition |
| DCLRE1CDNA cross-link repair 1C | Always | In 1 condition |
| DRG1developmentally regulated GTP binding protein 1 | Always | In 1 condition |
| IL2RAinterleukin 2 receptor subunit alpha | Always | In 1 condition |
| IL6STinterleukin 6 cytokine family signal transducer | Always | In 2 conditions |
| IRF4interferon regulatory factor 4 | Always | In 1 condition |
| LRRC7leucine rich repeat containing 7 | Always | In 1 condition |
| OSBPL2oxysterol binding protein like 2 | Always | In 1 condition |
| PEPDpeptidase D | Always | In 1 condition |
| PIK3CGphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma | Always | In 1 condition |
| PTCRApre T cell antigen receptor alpha | Always | In 1 condition |
| RAG1recombination activating 1 | Always | In 1 condition |
| RAG2recombination activating 2 | Always | In 1 condition |
| RNU6ATACRNA, U6atac small nuclear | Always | In 1 condition |
| SIK3SIK family kinase 3 | Always | In 1 condition |
| TOM1target of myb1 membrane trafficking protein | Always | In 1 condition |
| WIPF1WAS/WASL interacting protein family member 1 | Always | In 1 condition |
| ZNF341zinc finger protein 341 | Always | In 1 condition |
| CD28CD28 molecule | Very often (80–99%) | In 1 condition |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Very often (80–99%) | In 3 conditions |
| DOCK8dedicator of cytokinesis 8 | Very often (80–99%) | In 1 condition |
| FOXP3forkhead box P3 | Very often (80–99%) | In 2 conditions |
| HLA-DQB1major histocompatibility complex, class II, DQ beta 1 | Very often (80–99%) | In 2 conditions |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Very often (80–99%) | In 1 condition |
| PGM3phosphoglucomutase 3 | Very often (80–99%) | In 2 conditions |
| RNU12RNA, U12 small nuclear | Very often (80–99%) | In 1 condition |
| SPINK5serine peptidase inhibitor Kazal type 5 | Very often (80–99%) | In 2 conditions |
| STAT3signal transducer and activator of transcription 3 | Very often (80–99%) | In 3 conditions |
| TNFRSF1BTNF receptor superfamily member 1B | Very often (80–99%) | In 1 condition |
| WASWASP actin nucleation promoting factor | Very often (80–99%) | In 3 conditions |
| AARS1alanyl-tRNA synthetase 1 | Often (30–79%) | In 2 conditions |
| ADA2adenosine deaminase 2 | Often (30–79%) | In 1 condition |
| ARPC5actin related protein 2/3 complex subunit 5 | Often (30–79%) | In 1 condition |
| CARMIL2capping protein regulator and myosin 1 linker 2 | Often (30–79%) | In 1 condition |
| CSTAcystatin A | Often (30–79%) | In 1 condition |
| DPP9dipeptidyl peptidase 9 | Often (30–79%) | In 1 condition |
| FLGfilaggrin | Often (30–79%) | In 2 conditions |
| GGT1gamma-glutamyltransferase 1 | Often (30–79%) | In 1 condition |
| GINS1GINS complex subunit 1 | Often (30–79%) | In 1 condition |
Show 109 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| HDAC4histone deacetylase 4 | Often (30–79%) | In 2 conditions |
| IPO8importin 8 | Often (30–79%) | In 2 conditions |
| ITPR3inositol 1,4,5-trisphosphate receptor type 3 | Often (30–79%) | In 1 condition |
| KDF1keratinocyte differentiation factor 1 | Often (30–79%) | In 2 conditions |
| MAP2K1mitogen-activated protein kinase kinase 1 | Often (30–79%) | In 1 condition |
| MBTPS2membrane bound transcription factor peptidase, site 2 | Often (30–79%) | In 2 conditions |
| NAA10N-alpha-acetyltransferase 10, NatA catalytic subunit | Often (30–79%) | In 1 condition |
| NRASNRAS proto-oncogene, GTPase | Often (30–79%) | In 1 condition |
| NSMCE3NSE3 component of SMC5/6 complex | Often (30–79%) | In 1 condition |
| NUP107nucleoporin 107 | Often (30–79%) | In 1 condition |
| PRMT7protein arginine methyltransferase 7 | Often (30–79%) | In 2 conditions |
| RNF31ring finger protein 31 | Often (30–79%) | In 1 condition |
| RNU4ATACRNA, U4atac small nuclear | Often (30–79%) | In 2 conditions |
| SHOC2SHOC2 leucine rich repeat scaffold protein | Often (30–79%) | In 1 condition |
| SLC39A7solute carrier family 39 member 7 | Often (30–79%) | In 1 condition |
| SMAD2SMAD family member 2 | Often (30–79%) | In 1 condition |
| SMAD3SMAD family member 3 | Often (30–79%) | In 1 condition |
| SMARCA2SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2 | Often (30–79%) | In 2 conditions |
| SRD5A3steroid 5 alpha-reductase 3 | Often (30–79%) | In 1 condition |
| STAT1signal transducer and activator of transcription 1 | Often (30–79%) | In 2 conditions |
| STAT5Bsignal transducer and activator of transcription 5B | Often (30–79%) | In 2 conditions |
| TAF1TATA-box binding protein associated factor 1 | Often (30–79%) | In 1 condition |
| TGFB2transforming growth factor beta 2 | Often (30–79%) | In 1 condition |
| TGFB3transforming growth factor beta 3 | Often (30–79%) | In 1 condition |
| TGFBR1transforming growth factor beta receptor 1 | Often (30–79%) | In 1 condition |
| TGFBR2transforming growth factor beta receptor 2 | Often (30–79%) | In 1 condition |
| TGM5transglutaminase 5 | Often (30–79%) | In 1 condition |
| TPRtranslocated promoter region, nuclear basket protein | Often (30–79%) | In 1 condition |
| ASLargininosuccinate lyase | Sometimes (5–29%) | In 1 condition |
| AUTS2activator of transcription and developmental regulator AUTS2 | Sometimes (5–29%) | In 1 condition |
| BTDbiotinidase | Sometimes (5–29%) | In 1 condition |
| CAMK2Bcalcium/calmodulin dependent protein kinase II beta | Sometimes (5–29%) | In 1 condition |
| CARD14caspase recruitment domain family member 14 | Sometimes (5–29%) | In 1 condition |
| CARS1cysteinyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| CASRcalcium sensing receptor | Sometimes (5–29%) | In 1 condition |
| CYBAcytochrome b-245 alpha chain | Sometimes (5–29%) | In 2 conditions |
| CYBBcytochrome b-245 beta chain | Sometimes (5–29%) | In 2 conditions |
| CYBC1cytochrome b-245 chaperone 1 | Sometimes (5–29%) | In 2 conditions |
| DBR1debranching RNA lariats 1 | Sometimes (5–29%) | In 1 condition |
| DHRSXdehydrogenase/reductase X-linked | Sometimes (5–29%) | In 1 condition |
| DNAJC21DnaJ heat shock protein family (Hsp40) member C21 | Sometimes (5–29%) | In 2 conditions |
| DOT1LDOT1 like histone lysine methyltransferase | Sometimes (5–29%) | In 1 condition |
| EDARectodysplasin A receptor | Sometimes (5–29%) | In 1 condition |
| EDARADDEDAR associated via death domain | Sometimes (5–29%) | In 1 condition |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Sometimes (5–29%) | In 1 condition |
| ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit | Sometimes (5–29%) | In 1 condition |
| FECHferrochelatase | Sometimes (5–29%) | In 2 conditions |
| FLI1Fli-1 proto-oncogene, ETS transcription factor | Sometimes (5–29%) | In 2 conditions |
| FOCADfocadhesin | Sometimes (5–29%) | In 1 condition |
| FOXN1forkhead box N1 | Sometimes (5–29%) | In 2 conditions |
| GNA11G protein subunit alpha 11 | Sometimes (5–29%) | In 1 condition |
| GTF2E2general transcription factor IIE subunit 2 | Sometimes (5–29%) | In 1 condition |
| GTF2H5general transcription factor IIH subunit 5 | Sometimes (5–29%) | In 1 condition |
| H3-3BH3.3 histone B | Sometimes (5–29%) | In 1 condition |
| HLCSholocarboxylase synthetase | Sometimes (5–29%) | In 1 condition |
| HPGD15-hydroxyprostaglandin dehydrogenase | Sometimes (5–29%) | In 3 conditions |
| IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma | Sometimes (5–29%) | In 1 condition |
| IL17RAinterleukin 17 receptor A | Sometimes (5–29%) | In 1 condition |
| LBRlamin B receptor | Sometimes (5–29%) | In 1 condition |
| LEF1lymphoid enhancer binding factor 1 | Sometimes (5–29%) | In 1 condition |
| LGI3leucine rich repeat LGI family member 3 | Sometimes (5–29%) | In 1 condition |
| LIG1DNA ligase 1 | Sometimes (5–29%) | In 1 condition |
| LRP6LDL receptor related protein 6 | Sometimes (5–29%) | In 1 condition |
| MPDU1mannose-P-dolichol utilization defect 1 | Sometimes (5–29%) | In 1 condition |
| MPLKIPM-phase specific PLK1 interacting protein | Sometimes (5–29%) | In 1 condition |
| MYSM1Myb like, SWIRM and MPN domains 1 | Sometimes (5–29%) | In 2 conditions |
| NBEAneurobeachin | Sometimes (5–29%) | In 1 condition |
| NCF1neutrophil cytosolic factor 1 | Sometimes (5–29%) | In 2 conditions |
| NCF2neutrophil cytosolic factor 2 | Sometimes (5–29%) | In 2 conditions |
| NCF4neutrophil cytosolic factor 4 | Sometimes (5–29%) | In 1 condition |
| NFKBIANFKB inhibitor alpha | Sometimes (5–29%) | In 1 condition |
| NSUN2NOP2/Sun RNA methyltransferase 2 | Sometimes (5–29%) | In 1 condition |
| PGM2L1phosphoglucomutase 2 like 1 | Sometimes (5–29%) | In 1 condition |
| POLEDNA polymerase epsilon, catalytic subunit | Sometimes (5–29%) | In 1 condition |
| RAC1Rac family small GTPase 1 | Sometimes (5–29%) | In 2 conditions |
| RBCK1RANBP2-type and C3HC4-type zinc finger containing 1 | Sometimes (5–29%) | In 1 condition |
| RFX7regulatory factor X7 | Sometimes (5–29%) | In 1 condition |
| RIT1Ras like without CAAX 1 | Sometimes (5–29%) | In 1 condition |
| RNF113Aring finger protein 113A | Sometimes (5–29%) | In 1 condition |
| RTTNrotatin | Sometimes (5–29%) | In 1 condition |
| SIN3ASIN3 transcription regulator family member A | Sometimes (5–29%) | In 1 condition |
| SLCO2A1solute carrier organic anion transporter family member 2A1 | Sometimes (5–29%) | In 1 condition |
| SLF2SMC5/6 complex localization factor 2 | Sometimes (5–29%) | In 1 condition |
| SMARCC2SWI/SNF related BAF chromatin remodeling complex subunit C2 | Sometimes (5–29%) | In 1 condition |
| SMG8SMG8 nonsense mediated mRNA decay factor | Sometimes (5–29%) | In 1 condition |
| TARS1threonyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| TRAF6TNF receptor associated factor 6 | Sometimes (5–29%) | In 1 condition |
| EFL1elongation factor like GTPase 1 | Rarely (1–4%) | In 1 condition |
| IARS2isoleucyl-tRNA synthetase 2, mitochondrial | Rarely (1–4%) | In 1 condition |
| PPP2R5Cprotein phosphatase 2 regulatory subunit B'gamma | Rarely (1–4%) | In 1 condition |
| SBDSSBDS ribosome maturation factor | Rarely (1–4%) | In 1 condition |
| TBCKTBC1 domain containing kinase | Rarely (1–4%) | In 1 condition |
| CD3GCD3 gamma subunit of T-cell receptor complex | Not recorded | In 1 condition |
| DDX41DEAD-box helicase 41 | Not recorded | In 1 condition |
| DHCR77-dehydrocholesterol reductase | Not recorded | In 1 condition |
| EDAectodysplasin A | Not recorded | In 1 condition |
| HLA-DQA1major histocompatibility complex, class II, DQ alpha 1 | Not recorded | In 1 condition |
| IL7Rinterleukin 7 receptor | Not recorded | In 1 condition |
| KANSL1KAT8 regulatory NSL complex subunit 1 | Not recorded | In 1 condition |
| MSNmoesin | Not recorded | In 1 condition |
| MTHFD1methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 | Not recorded | In 1 condition |
| NOD2nucleotide binding oligomerization domain containing 2 | Not recorded | In 1 condition |
| PAHphenylalanine hydroxylase | Not recorded | In 1 condition |
| PCCApropionyl-CoA carboxylase subunit alpha | Not recorded | In 1 condition |
| PCCBpropionyl-CoA carboxylase subunit beta | Not recorded | In 1 condition |
| SLC30A2solute carrier family 30 member 2 | Not recorded | In 1 condition |
| SUOXsulfite oxidase | Not recorded | In 1 condition |
| TP63tumor protein p63 | Not recorded | In 1 condition |
| ZAP70zeta chain of T cell receptor associated protein kinase 70 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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