Trait
Bad bite
Clinical name: Dental malocclusion
Dental malocclusion refers to an abnormality of the occlusion, or alignment, of the teeth and the way the upper and lower teeth fit together, resulting in overcrowding of teeth or in abnormal bite patterns.
Summary
- Also called
- Malalignment of upper and lower dental arches, Misalignment of upper and lower dental arches, Bilateral crossbite, Bilateral crossbite malocclusion, Incorrect relation between upper and lower dental arches, Malocclusion, Malocclusion of teeth, Occlusion anomaly
- Body system
- Abnormality of head or neck
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test156 genes linked to Bad bite
Changes in these genes cause rare conditions in which Bad bite is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ANKHANKH inorganic pyrophosphate transport regulator | Always | In 1 condition |
| ASPHaspartate beta-hydroxylase | Always | In 1 condition |
| BRF1BRF1 general transcription factor IIIB subunit | Always | In 2 conditions |
| CDC42cell division cycle 42 | Always | In 2 conditions |
| CDH11cadherin 11 | Always | In 1 condition |
| CREBBPCREB binding lysine acetyltransferase | Always | In 3 conditions |
| DDX59DEAD-box helicase 59 | Always | In 1 condition |
| DHRS3dehydrogenase/reductase 3 | Always | In 1 condition |
| EFEMP1EGF-like fibulin extracellular matrix protein 1 | Always | In 1 condition |
| EP300EP300 lysine acetyltransferase | Always | In 3 conditions |
| FLNAfilamin A | Always | In 2 conditions |
| IL11RAinterleukin 11 receptor subunit alpha | Always | In 1 condition |
| IRX5iroquois homeobox 5 | Always | In 1 condition |
| MARS1methionyl-tRNA synthetase 1 | Always | In 1 condition |
| MOCS3molybdenum cofactor synthesis 3 | Always | In 1 condition |
| MYOD1myogenic differentiation 1 | Always | In 1 condition |
| NHSNHS actin remodeling regulator | Always | In 1 condition |
| NSD1nuclear receptor binding SET domain protein 1 | Always | In 1 condition |
| PPFIA3PPFI scaffold protein A3 | Always | In 1 condition |
| RDH11retinol dehydrogenase 11 | Always | In 2 conditions |
| TSPAN7tetraspanin 7 | Always | In 1 condition |
| FGFR2fibroblast growth factor receptor 2 | Very often (80–99%) | In 2 conditions |
| ABCC9ATP binding cassette subfamily C member 9 | Often (30–79%) | In 1 condition |
| BANF1barrier to autointegration nuclear assembly factor 1 | Often (30–79%) | In 1 condition |
| BAZ1Bbromodomain adjacent to zinc finger domain 1B | Often (30–79%) | In 1 condition |
| BUD23BUD23 rRNA methyltransferase and ribosome maturation factor | Often (30–79%) | In 1 condition |
| CHRNGcholinergic receptor nicotinic gamma subunit | Often (30–79%) | In 1 condition |
| CLIP2CAP-Gly domain containing linker protein 2 | Often (30–79%) | In 1 condition |
| DNAJC30DnaJ heat shock protein family (Hsp40) member C30 | Often (30–79%) | In 1 condition |
| DOCK3dedicator of cytokinesis 3 | Often (30–79%) | In 1 condition |
| EDAectodysplasin A | Often (30–79%) | In 1 condition |
| EDARADDEDAR associated via death domain | Often (30–79%) | In 1 condition |
| EDN1endothelin 1 | Often (30–79%) | In 1 condition |
| EIF4Heukaryotic translation initiation factor 4H | Often (30–79%) | In 1 condition |
| ELNelastin | Often (30–79%) | In 2 conditions |
| FGFR1fibroblast growth factor receptor 1 | Often (30–79%) | In 1 condition |
| FKBP6FKBP prolyl isomerase family member 6 (inactive) | Often (30–79%) | In 1 condition |
| FRAS1Fraser extracellular matrix complex subunit 1 | Often (30–79%) | In 2 conditions |
| FREM2FRAS1 related extracellular matrix 2 | Often (30–79%) | In 1 condition |
| GLI2GLI family zinc finger 2 | Often (30–79%) | In 1 condition |
Show 116 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| GNAI3G protein subunit alpha i3 | Often (30–79%) | In 2 conditions |
| GREM2gremlin 2, DAN family BMP antagonist | Often (30–79%) | In 1 condition |
| GRIP1glutamate receptor interacting protein 1 | Often (30–79%) | In 1 condition |
| GTF2Igeneral transcription factor IIi | Often (30–79%) | In 1 condition |
| GTF2IRD1GTF2I repeat domain containing 1 | Often (30–79%) | In 1 condition |
| GTF2IRD2GTF2I repeat domain containing 2 | Often (30–79%) | In 1 condition |
| HNRNPKheterogeneous nuclear ribonucleoprotein K | Often (30–79%) | In 3 conditions |
| IRF6interferon regulatory factor 6 | Often (30–79%) | In 2 conditions |
| LIMK1LIM domain kinase 1 | Often (30–79%) | In 1 condition |
| LRP6LDL receptor related protein 6 | Often (30–79%) | In 1 condition |
| METTL27methyltransferase like 27 | Often (30–79%) | In 1 condition |
| MLXIPLMLX interacting protein like | Often (30–79%) | In 1 condition |
| MSX1msh homeobox 1 | Often (30–79%) | In 2 conditions |
| NCF1neutrophil cytosolic factor 1 | Often (30–79%) | In 1 condition |
| PAX9paired box 9 | Often (30–79%) | In 1 condition |
| PLCB4phospholipase C beta 4 | Often (30–79%) | In 2 conditions |
| POLR1BRNA polymerase I subunit B | Often (30–79%) | In 1 condition |
| POLR1CRNA polymerase I and III subunit C | Often (30–79%) | In 1 condition |
| POLR1DRNA polymerase I and III subunit D | Often (30–79%) | In 1 condition |
| PORCNporcupine O-acyltransferase | Often (30–79%) | In 2 conditions |
| PTH1Rparathyroid hormone 1 receptor | Often (30–79%) | In 1 condition |
| RFC2replication factor C subunit 2 | Often (30–79%) | In 1 condition |
| SFRP4secreted frizzled related protein 4 | Often (30–79%) | In 1 condition |
| SHANK3SH3 and multiple ankyrin repeat domains 3 | Often (30–79%) | In 1 condition |
| SMAD3SMAD family member 3 | Often (30–79%) | In 2 conditions |
| STX1Asyntaxin 1A | Often (30–79%) | In 1 condition |
| SUMO1small ubiquitin like modifier 1 | Often (30–79%) | In 1 condition |
| TBL2transducin beta like 2 | Often (30–79%) | In 1 condition |
| TCOF1treacle ribosome biogenesis factor 1 | Often (30–79%) | In 1 condition |
| TGFAtransforming growth factor alpha | Often (30–79%) | In 1 condition |
| THOC6THO complex subunit 6 | Often (30–79%) | In 2 conditions |
| TMEM270transmembrane protein 270 | Often (30–79%) | In 1 condition |
| TRIM37tripartite motif containing 37 | Often (30–79%) | In 1 condition |
| TTI2TELO2 interacting protein 2 | Often (30–79%) | In 1 condition |
| VPS37DVPS37D subunit of ESCRT-I | Often (30–79%) | In 1 condition |
| WNT10AWnt family member 10A | Often (30–79%) | In 1 condition |
| WNT10BWnt family member 10B | Often (30–79%) | In 1 condition |
| ACP5acid phosphatase 5, tartrate resistant | Sometimes (5–29%) | In 1 condition |
| AGO2argonaute RISC catalytic component 2 | Sometimes (5–29%) | In 1 condition |
| AIPAHR interacting HSP90 co-chaperone | Sometimes (5–29%) | In 1 condition |
| ARHGAP29Rho GTPase activating protein 29 | Sometimes (5–29%) | In 1 condition |
| ARHGEF38Rho guanine nucleotide exchange factor 38 | Sometimes (5–29%) | In 1 condition |
| BMP4bone morphogenetic protein 4 | Sometimes (5–29%) | In 1 condition |
| CDH1cadherin 1 | Sometimes (5–29%) | In 1 condition |
| COBLL1cordon-bleu WH2 repeat protein like 1 | Sometimes (5–29%) | In 1 condition |
| CTSKcathepsin K | Sometimes (5–29%) | In 1 condition |
| DLG1discs large MAGUK scaffold protein 1 | Sometimes (5–29%) | In 1 condition |
| DLX4distal-less homeobox 4 | Sometimes (5–29%) | In 1 condition |
| DPM2dolichyl-phosphate mannosyltransferase subunit 2, regulatory | Sometimes (5–29%) | In 1 condition |
| DVL3dishevelled segment polarity protein 3 | Sometimes (5–29%) | In 1 condition |
| FGD1FYVE, RhoGEF and PH domain containing 1 | Sometimes (5–29%) | In 1 condition |
| GNAQG protein subunit alpha q | Sometimes (5–29%) | In 1 condition |
| GNASGNAS complex locus | Sometimes (5–29%) | In 1 condition |
| GPR101G protein-coupled receptor 101 | Sometimes (5–29%) | In 1 condition |
| GRHL3grainyhead like transcription factor 3 | Sometimes (5–29%) | In 1 condition |
| HSPG2heparan sulfate proteoglycan 2 | Sometimes (5–29%) | In 1 condition |
| KDM6Alysine demethylase 6A | Sometimes (5–29%) | In 2 conditions |
| KMT2Dlysine methyltransferase 2D | Sometimes (5–29%) | In 1 condition |
| MEGF8multiple EGF like domains 8 | Sometimes (5–29%) | In 1 condition |
| NECTIN1nectin cell adhesion molecule 1 | Sometimes (5–29%) | In 1 condition |
| PAX1paired box 1 | Sometimes (5–29%) | In 1 condition |
| PDGFRAplatelet derived growth factor receptor alpha | Sometimes (5–29%) | In 1 condition |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Sometimes (5–29%) | In 1 condition |
| PSMD12proteasome 26S subunit, non-ATPase 12 | Sometimes (5–29%) | In 1 condition |
| PYROXD1pyridine nucleotide-disulphide oxidoreductase domain 1 | Sometimes (5–29%) | In 1 condition |
| RHOAras homolog family member A | Sometimes (5–29%) | In 1 condition |
| RIC1RIC1 partner of RAB6A GEF complex | Sometimes (5–29%) | In 1 condition |
| SATB2SATB homeobox 2 | Sometimes (5–29%) | In 1 condition |
| SMARCA2SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2 | Sometimes (5–29%) | In 1 condition |
| SMCHD1structural maintenance of chromosomes flexible hinge domain containing 1 | Sometimes (5–29%) | In 1 condition |
| TCF12transcription factor 12 | Sometimes (5–29%) | In 1 condition |
| TP63tumor protein p63 | Sometimes (5–29%) | In 1 condition |
| TWIST2twist family bHLH transcription factor 2 | Sometimes (5–29%) | In 1 condition |
| CLCN7Cl-/H+ antiporter 7 | Rarely (1–4%) | In 1 condition |
| PLEKHM1pleckstrin homology and RUN domain containing M1 | Rarely (1–4%) | In 1 condition |
| TCIRG1T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 | Rarely (1–4%) | In 1 condition |
| AMER1APC membrane recruitment protein 1 | Not recorded | In 1 condition |
| ATRATR checkpoint kinase | Not recorded | In 1 condition |
| BCORBCL6 corepressor | Not recorded | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Not recorded | In 2 conditions |
| BRCA1BRCA1 DNA repair associated | Not recorded | In 1 condition |
| CA2carbonic anhydrase 2 | Not recorded | In 1 condition |
| CHRNEcholinergic receptor nicotinic epsilon subunit | Not recorded | In 1 condition |
| DCHS1dachsous cadherin-related 1 | Not recorded | In 1 condition |
| DVL1dishevelled segment polarity protein 1 | Not recorded | In 1 condition |
| ERCC6ERCC excision repair 6, chromatin remodeling factor | Not recorded | In 1 condition |
| ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit | Not recorded | In 1 condition |
| FAT4FAT atypical cadherin 4 | Not recorded | In 1 condition |
| FGFR3fibroblast growth factor receptor 3 | Not recorded | In 1 condition |
| FLCNfolliculin | Not recorded | In 1 condition |
| GFPT1glutamine--fructose-6-phosphate transaminase 1 | Not recorded | In 1 condition |
| GJA1gap junction protein alpha 1 | Not recorded | In 1 condition |
| GPC3glypican 3 | Not recorded | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Not recorded | In 1 condition |
| LRP5LDL receptor related protein 5 | Not recorded | In 1 condition |
| MAP2K1mitogen-activated protein kinase kinase 1 | Not recorded | In 2 conditions |
| MAP2K2mitogen-activated protein kinase kinase 2 | Not recorded | In 1 condition |
| MTM1myotubularin 1 | Not recorded | In 1 condition |
| MUSKmuscle associated receptor tyrosine kinase | Not recorded | In 1 condition |
| NOTCH2notch receptor 2 | Not recorded | In 1 condition |
| OBSL1obscurin like cytoskeletal adaptor 1 | Not recorded | In 1 condition |
| PCGF2polycomb group ring finger 2 | Not recorded | In 1 condition |
| PCYT1Aphosphate cytidylyltransferase 1A, choline | Not recorded | In 1 condition |
| PIK3R1phosphoinositide-3-kinase regulatory subunit 1 | Not recorded | In 1 condition |
| PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha | Not recorded | In 1 condition |
| PTPN11protein tyrosine phosphatase non-receptor type 11 | Not recorded | In 1 condition |
| RAI1retinoic acid induced 1 | Not recorded | In 1 condition |
| RPS6KA3ribosomal protein S6 kinase A3 | Not recorded | In 1 condition |
| SACK1Hscaffolding CK1 anchoring protein H | Not recorded | In 1 condition |
| SH3BP2SH3 domain binding protein 2 | Not recorded | In 1 condition |
| SH3PXD2BSH3 and PX domains 2B | Not recorded | In 1 condition |
| SKISKI proto-oncogene | Not recorded | In 1 condition |
| SLC39A13solute carrier family 39 member 13 | Not recorded | In 1 condition |
| SOS1SOS Ras/Rac guanine nucleotide exchange factor 1 | Not recorded | In 1 condition |
| SOSTsclerostin | Not recorded | In 1 condition |
| TRPS1transcriptional repressor GATA binding 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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