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Gene

FANCM

FA complementation group M

Summary

Cytogenetic location
14q21.2
Coordinates
Chromosome 14: 45,135,930–45,200,890 (GRCh38)
Exons
23 exons across 65 kb
Protein
2,048 amino acids
Also known as
FAAP250
Previous symbols
KIAA1596
MANE Select transcript
ENST00000267430.10NM_020937.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Female Infertility

    • Diminished or absent ability of a female to achieve conception.

      • 1 GenCC submitter rates it definitive or strong

  • Male Infertility

    • The inability of the male to effect fertilization of an ovum after a specified period of unprotected intercourse. Male sterility is permanent infertility.

      • 3 GenCC submitters rate it definitive or strong

How FANCM is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 14, with a bracket where FANCM sits. FANCM and 6 genes near it on chromosome 14, from 44,668,410 to 45,668,409.Chromosome 1414q21.2p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.11q32.12q32.13q32.2q32.31q32.32q32.3344.8 Mb45 Mb45.2 Mb45.4 Mb45.6 MbDORIP1: 44,897,200–44,907,257, forward strandDORIP1KLHL28: 44,924,324–45,042,322, reverse strandKLHL28TOGARAM1: 44,962,183–45,074,431, forward strandTOGARAM1PRPF39: 45,084,074–45,116,282, forward strandPRPF39FKBP3: 45,112,188–45,135,319, reverse strandFKBP3FANCM: 45,135,930–45,200,890, forward strandFANCMMIS18BP1: 45,203,125–45,253,542, reverse strandMIS18BP1Diagram of FANCM: 23 exons on the forward strand of chromosome 14Exon 1: 6 known disease-causing sitesExon 2: 7 known disease-causing sitesExon 3: 2 known disease-causing sitesExon 4: 4 known disease-causing sitesExon 5: 1 known disease-causing siteExon 6: 4 known disease-causing sitesExon 7: 4 known disease-causing sitesExon 8: 2 known disease-causing sitesExon 9: 7 known disease-causing sitesExon 10: 5 known disease-causing sitesExon 11: 7 known disease-causing sitesExon 12: 7 known disease-causing sitesExon 13: 5 known disease-causing sitesExon 14: 44 known disease-causing sitesExon 15: 5 known disease-causing sitesExon 17: 5 known disease-causing sitesExon 18: 5 known disease-causing sitesExon 19: 2 known disease-causing sitesExon 20: 10 known disease-causing sitesExon 21: 12 known disease-causing sitesExon 22: 5 known disease-causing sitesExon 1: 45,135,930–45,136,539, 610 basesExon 2: 45,137,069–45,137,241, 173 basesExon 3: 45,140,632–45,140,709, 78 basesExon 4: 45,148,837–45,148,995, 159 basesExon 5: 45,151,397–45,151,528, 132 basesExon 6: 45,153,920–45,154,052, 133 basesExon 7: 45,154,697–45,154,822, 126 basesExon 8: 45,155,373–45,155,459, 87 basesExon 9: 45,159,096–45,159,280, 185 basesExon 10: 45,164,359–45,164,565, 207 basesExon 11: 45,166,950–45,167,163, 214 basesExon 12: 45,170,589–45,170,746, 158 basesExon 13: 45,173,055–45,173,210, 156 basesExon 14: 45,175,071–45,176,976, 1,906 basesExon 15: 45,181,430–45,181,524, 95 basesExon 16: 45,181,637–45,181,705, 69 basesExon 17: 45,183,774–45,183,902, 129 basesExon 18: 45,185,217–45,185,373, 157 basesExon 19: 45,187,781–45,187,887, 107 basesExon 20: 45,188,802–45,189,362, 561 basesExon 21: 45,196,172–45,196,547, 376 basesExon 22: 45,198,644–45,198,935, 292 basesExon 23: 45,199,870–45,200,890, 1,021 bases15101520235′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 7.1 kb of the gene's 65 kb; 6,147 of those bases code for the protein.

How a genome test reads FANCM

168

positions in FANCM where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 65 kb of FANCM, introns included, not only the 7.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). FANCM gene: FA complementation group M. Retrieved 16 October 2026, from https://dantelabs.com/genes/fancm

Vancouver

Dante Labs. FANCM gene: FA complementation group M [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/fancm

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