Trait
Narrow mouth
Distance between the commissures of the mouth more than 2 SD below the mean. Alternatively, an apparently decreased width of the oral aperture (subjective).
Summary
- Also called
- Small mouth, Microstomia, Small oral aperture
- Body system
- Abnormality of head or neck
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Narrow mouth, and the rest of your genome, with one test.
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Get my Genome Test245 genes linked to Narrow mouth
Changes in these genes cause rare conditions in which Narrow mouth is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AMMECR1AMMECR nuclear protein 1 | Always | In 1 condition |
| BBS7Bardet-Biedl syndrome 7 | Always | In 1 condition |
| CACNA1Ccalcium voltage-gated channel subunit alpha1 C | Always | In 1 condition |
| CEP57centrosomal protein 57 | Always | In 1 condition |
| CHST14carbohydrate sulfotransferase 14 | Always | In 2 conditions |
| COG7component of oligomeric golgi complex 7 | Always | In 2 conditions |
| CREBBPCREB binding lysine acetyltransferase | Always | In 1 condition |
| DCPSdecapping enzyme, scavenger | Always | In 1 condition |
| DONSONDNA replication fork stabilization factor DONSON | Always | In 2 conditions |
| EIF4A2eukaryotic translation initiation factor 4A2 | Always | In 1 condition |
| EP300EP300 lysine acetyltransferase | Always | In 2 conditions |
| FGFR2fibroblast growth factor receptor 2 | Always | In 2 conditions |
| FLNAfilamin A | Always | In 3 conditions |
| GLB1galactosidase beta 1 | Always | In 1 condition |
| GNB2G protein subunit beta 2 | Always | In 1 condition |
| KARS1lysyl-tRNA synthetase 1 | Always | In 1 condition |
| MCM5minichromosome maintenance complex component 5 | Always | In 1 condition |
| MDM2MDM2 proto-oncogene | Always | In 1 condition |
| MED12mediator complex subunit 12 | Always | In 1 condition |
| MED16mediator complex subunit 16 | Always | In 1 condition |
| MYH3myosin heavy chain 3 | Always | In 4 conditions |
| NAA80N-alpha-acetyltransferase 80, NatH catalytic subunit | Always | In 1 condition |
| NOTCH2notch receptor 2 | Always | In 2 conditions |
| ORC4origin recognition complex subunit 4 | Always | In 2 conditions |
| PLCB4phospholipase C beta 4 | Always | In 3 conditions |
| PRRX1paired related homeobox 1 | Always | In 2 conditions |
| PSMD12proteasome 26S subunit, non-ATPase 12 | Always | In 1 condition |
| SCARF2scavenger receptor class F member 2 | Always | In 2 conditions |
| SCYL2SCY1 like pseudokinase 2 | Always | In 1 condition |
| SP7Sp7 transcription factor | Always | In 1 condition |
| TM2D3TM2 domain containing 3 | Always | In 1 condition |
| TMLHEtrimethyllysine hydroxylase, epsilon | Always | In 1 condition |
| TOP2BDNA topoisomerase II beta | Always | In 1 condition |
| TP63tumor protein p63 | Always | In 1 condition |
| TUBBtubulin beta class I | Always | In 1 condition |
| UBE3Bubiquitin protein ligase E3B | Always | In 1 condition |
| ZMPSTE24zinc metallopeptidase STE24 | Always | In 5 conditions |
| B4GALT7beta-1,4-galactosyltransferase 7 | Very often (80–99%) | In 2 conditions |
| BCL11ABCL11 transcription factor A | Very often (80–99%) | In 1 condition |
| CDC45cell division cycle 45 | Very often (80–99%) | In 2 conditions |
Show 205 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| CDC6cell division cycle 6 | Very often (80–99%) | In 1 condition |
| CDT1chromatin licensing and DNA replication factor 1 | Very often (80–99%) | In 2 conditions |
| DSEdermatan sulfate epimerase | Very often (80–99%) | In 2 conditions |
| EIF4A3eukaryotic translation initiation factor 4A3 | Very often (80–99%) | In 1 condition |
| GMNNgeminin DNA replication inhibitor | Very often (80–99%) | In 1 condition |
| HDAC9histone deacetylase 9 | Very often (80–99%) | In 1 condition |
| HSPG2heparan sulfate proteoglycan 2 | Very often (80–99%) | In 5 conditions |
| IARS2isoleucyl-tRNA synthetase 2, mitochondrial | Very often (80–99%) | In 2 conditions |
| LMNAlamin A/C | Very often (80–99%) | In 2 conditions |
| MADDMAP kinase activating death domain | Very often (80–99%) | In 1 condition |
| NALCNsodium leak channel, non-selective | Very often (80–99%) | In 3 conditions |
| ORC1origin recognition complex subunit 1 | Very often (80–99%) | In 2 conditions |
| ORC6origin recognition complex subunit 6 | Very often (80–99%) | In 2 conditions |
| OTX2orthodenticle homeobox 2 | Very often (80–99%) | In 1 condition |
| PAFAH1B1platelet activating factor acetylhydrolase 1b regulatory subunit 1 | Very often (80–99%) | In 1 condition |
| PAX3paired box 3 | Very often (80–99%) | In 1 condition |
| PIEZO2piezo type mechanosensitive ion channel component 2 | Very often (80–99%) | In 2 conditions |
| POLR3ARNA polymerase III subunit A | Very often (80–99%) | In 2 conditions |
| PQBP1polyglutamine binding protein 1 | Very often (80–99%) | In 2 conditions |
| PTCH1patched 1 | Very often (80–99%) | In 1 condition |
| RELREL proto-oncogene, NF-kB subunit | Very often (80–99%) | In 1 condition |
| SH2B1SH2B adaptor protein 1 | Very often (80–99%) | In 1 condition |
| SMAD4SMAD family member 4 | Very often (80–99%) | In 2 conditions |
| XPO1exportin 1 | Very often (80–99%) | In 1 condition |
| YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon | Very often (80–99%) | In 1 condition |
| AKT3AKT serine/threonine kinase 3 | Often (30–79%) | In 1 condition |
| APCAPC regulator of Wnt signaling pathway | Often (30–79%) | In 1 condition |
| ATP6V1E1ATPase H+ transporting V1 subunit E1 | Often (30–79%) | In 1 condition |
| ATXN7L3ataxin 7 like 3 | Often (30–79%) | In 1 condition |
| AUTS2activator of transcription and developmental regulator AUTS2 | Often (30–79%) | In 2 conditions |
| B3GAT3beta-1,3-glucuronyltransferase 3 | Often (30–79%) | In 1 condition |
| BMP2bone morphogenetic protein 2 | Often (30–79%) | In 1 condition |
| CASZ1castor zinc finger 1 | Often (30–79%) | In 1 condition |
| CAV1caveolin 1 | Often (30–79%) | In 1 condition |
| CCND2cyclin D2 | Often (30–79%) | In 1 condition |
| CDK13cyclin dependent kinase 13 | Often (30–79%) | In 1 condition |
| CENPTcentromere protein T | Often (30–79%) | In 1 condition |
| CHD6chromodomain helicase DNA binding protein 6 | Often (30–79%) | In 1 condition |
| CHD7chromodomain helicase DNA binding protein 7 | Often (30–79%) | In 1 condition |
| CHRNGcholinergic receptor nicotinic gamma subunit | Often (30–79%) | In 1 condition |
| CHST3carbohydrate sulfotransferase 3 | Often (30–79%) | In 1 condition |
| COG1component of oligomeric golgi complex 1 | Often (30–79%) | In 2 conditions |
| COL11A1collagen type XI alpha 1 chain | Often (30–79%) | In 2 conditions |
| COL11A2collagen type XI alpha 2 chain | Often (30–79%) | In 1 condition |
| DHCR2424-dehydrocholesterol reductase | Often (30–79%) | In 1 condition |
| ECEL1endothelin converting enzyme like 1 | Often (30–79%) | In 1 condition |
| EDN1endothelin 1 | Often (30–79%) | In 1 condition |
| FAT4FAT atypical cadherin 4 | Often (30–79%) | In 3 conditions |
| FBN1fibrillin 1 | Often (30–79%) | In 2 conditions |
| GABRA3gamma-aminobutyric acid type A receptor subunit alpha3 | Often (30–79%) | In 1 condition |
| GABRDgamma-aminobutyric acid type A receptor subunit delta | Often (30–79%) | In 1 condition |
| GNAI3G protein subunit alpha i3 | Often (30–79%) | In 2 conditions |
| HIVEP2HIVEP zinc finger 2 | Often (30–79%) | In 1 condition |
| KAT6Alysine acetyltransferase 6A | Often (30–79%) | In 1 condition |
| KCNAB2potassium voltage-gated channel subfamily A regulatory beta subunit 2 | Often (30–79%) | In 1 condition |
| LEMD2LEM domain nuclear envelope protein 2 | Often (30–79%) | In 1 condition |
| LGI3leucine rich repeat LGI family member 3 | Often (30–79%) | In 1 condition |
| LMX1BLIM homeobox transcription factor 1 beta | Often (30–79%) | In 1 condition |
| LTBP3latent transforming growth factor beta binding protein 3 | Often (30–79%) | In 1 condition |
| LUZP1leucine zipper protein 1 | Often (30–79%) | In 1 condition |
| MAFMAF bZIP transcription factor | Often (30–79%) | In 2 conditions |
| MMP23Bmatrix metallopeptidase 23B | Often (30–79%) | In 1 condition |
| MTX2metaxin 2 | Often (30–79%) | In 1 condition |
| MYL11myosin light chain 11 | Often (30–79%) | In 1 condition |
| NEBnebulin | Often (30–79%) | In 1 condition |
| NFIXnuclear factor I X | Often (30–79%) | In 3 conditions |
| NONOnon-POU domain containing octamer binding | Often (30–79%) | In 1 condition |
| PCGF2polycomb group ring finger 2 | Often (30–79%) | In 1 condition |
| PDPNpodoplanin | Often (30–79%) | In 1 condition |
| PHACTR1phosphatase and actin regulator 1 | Often (30–79%) | In 1 condition |
| PIGAphosphatidylinositol glycan anchor biosynthesis class A | Often (30–79%) | In 1 condition |
| PIGFphosphatidylinositol glycan anchor biosynthesis class F | Often (30–79%) | In 1 condition |
| PIK3R2phosphoinositide-3-kinase regulatory subunit 2 | Often (30–79%) | In 1 condition |
| PRDM16PR/SET domain 16 | Often (30–79%) | In 1 condition |
| PRKCZprotein kinase C zeta | Often (30–79%) | In 1 condition |
| RBSNrabenosyn, RAB effector | Often (30–79%) | In 1 condition |
| RECQL4RecQ like helicase 4 | Often (30–79%) | In 2 conditions |
| REREarginine-glutamic acid dipeptide repeats | Often (30–79%) | In 1 condition |
| RIPK4receptor interacting serine/threonine kinase 4 | Often (30–79%) | In 1 condition |
| RNF2ring finger protein 2 | Often (30–79%) | In 1 condition |
| RNH1ribonuclease/angiogenin inhibitor 1 | Often (30–79%) | In 1 condition |
| RSPO2R-spondin 2 | Often (30–79%) | In 1 condition |
| SCNM1sodium channel modifier 1 | Often (30–79%) | In 1 condition |
| SEMA3Esemaphorin 3E | Often (30–79%) | In 1 condition |
| SKISKI proto-oncogene | Often (30–79%) | In 1 condition |
| SPEGstriated muscle enriched protein kinase | Often (30–79%) | In 2 conditions |
| SPENspen family transcriptional repressor | Often (30–79%) | In 1 condition |
| STXBP1syntaxin binding protein 1 | Often (30–79%) | In 1 condition |
| TBX4T-box transcription factor 4 | Often (30–79%) | In 2 conditions |
| TRIM33tripartite motif containing 33 | Often (30–79%) | In 1 condition |
| TRIP4thyroid hormone receptor interactor 4 | Often (30–79%) | In 1 condition |
| TRMT5tRNA methyltransferase 5 | Often (30–79%) | In 1 condition |
| TWIST1twist family bHLH transcription factor 1 | Often (30–79%) | In 1 condition |
| UBE4Bubiquitination factor E4B | Often (30–79%) | In 1 condition |
| WNT3Wnt family member 3 | Often (30–79%) | In 1 condition |
| ZBTB20zinc finger and BTB domain containing 20 | Often (30–79%) | In 1 condition |
| ADAMTS3ADAM metallopeptidase with thrombospondin type 1 motif 3 | Sometimes (5–29%) | In 1 condition |
| AHDC1AT-hook DNA binding motif containing 1 | Sometimes (5–29%) | In 1 condition |
| ARVCFARVCF delta catenin family member | Sometimes (5–29%) | In 1 condition |
| ASXL1ASXL transcriptional regulator 1 | Sometimes (5–29%) | In 1 condition |
| BCL11BBCL11 transcription factor B | Sometimes (5–29%) | In 1 condition |
| BCRBCR activator of RhoGEF and GTPase | Sometimes (5–29%) | In 1 condition |
| BIN1bridging integrator 1 | Sometimes (5–29%) | In 1 condition |
| BMPR1Abone morphogenetic protein receptor type 1A | Sometimes (5–29%) | In 1 condition |
| BPTFbromodomain PHD finger transcription factor | Sometimes (5–29%) | In 1 condition |
| CA2carbonic anhydrase 2 | Sometimes (5–29%) | In 1 condition |
| CAMTA1calmodulin binding transcription activator 1 | Sometimes (5–29%) | In 2 conditions |
| CCBE1collagen and calcium binding EGF domains 1 | Sometimes (5–29%) | In 2 conditions |
| CHSY1chondroitin sulfate synthase 1 | Sometimes (5–29%) | In 1 condition |
| CLCF1cardiotrophin like cytokine factor 1 | Sometimes (5–29%) | In 1 condition |
| CLCN3Cl-/H+ antiporter 3 | Sometimes (5–29%) | In 1 condition |
| COL3A1collagen type III alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| COL7A1collagen type VII alpha 1 chain | Sometimes (5–29%) | In 3 conditions |
| COMTcatechol-O-methyltransferase | Sometimes (5–29%) | In 1 condition |
| CRELD1CRELD disulfide isomerase 1 | Sometimes (5–29%) | In 1 condition |
| CRKLCRK like proto-oncogene, adaptor protein | Sometimes (5–29%) | In 1 condition |
| CRLF1cytokine receptor like factor 1 | Sometimes (5–29%) | In 2 conditions |
| CTCFCCCTC-binding factor | Sometimes (5–29%) | In 2 conditions |
| DCHS1dachsous cadherin-related 1 | Sometimes (5–29%) | In 1 condition |
| DLK1delta like non-canonical Notch ligand 1 | Sometimes (5–29%) | In 2 conditions |
| EXTL3exostosin like glycosyltransferase 3 | Sometimes (5–29%) | In 1 condition |
| FBXO11F-box protein 11 | Sometimes (5–29%) | In 1 condition |
| FREM2FRAS1 related extracellular matrix 2 | Sometimes (5–29%) | In 1 condition |
| GP1BBglycoprotein Ib platelet subunit beta | Sometimes (5–29%) | In 1 condition |
| GRB10growth factor receptor bound protein 10 | Sometimes (5–29%) | In 1 condition |
| GSCgoosecoid homeobox | Sometimes (5–29%) | In 1 condition |
| HEATR3HEAT repeat containing 3 | Sometimes (5–29%) | In 1 condition |
| HECTD4HECT domain E3 ubiquitin protein ligase 4 | Sometimes (5–29%) | In 1 condition |
| HIRAhistone cell cycle regulator | Sometimes (5–29%) | In 1 condition |
| JMJD1Cjumonji domain containing 1C | Sometimes (5–29%) | In 1 condition |
| KDM2Blysine demethylase 2B | Sometimes (5–29%) | In 1 condition |
| MAPK1mitogen-activated protein kinase 1 | Sometimes (5–29%) | In 1 condition |
| MAPRE2microtubule associated protein RP/EB family member 2 | Sometimes (5–29%) | In 1 condition |
| MED12Lmediator complex subunit 12L | Sometimes (5–29%) | In 1 condition |
| MEG3maternally expressed 3 | Sometimes (5–29%) | In 2 conditions |
| MMP1matrix metallopeptidase 1 | Sometimes (5–29%) | In 1 condition |
| MUSKmuscle associated receptor tyrosine kinase | Sometimes (5–29%) | In 1 condition |
| MYBPC1myosin binding protein C1 | Sometimes (5–29%) | In 2 conditions |
| NEDD4LNEDD4 like E3 ubiquitin protein ligase | Sometimes (5–29%) | In 1 condition |
| PIGNphosphatidylinositol glycan anchor biosynthesis class N | Sometimes (5–29%) | In 1 condition |
| POGZpogo transposable element derived with ZNF domain | Sometimes (5–29%) | In 1 condition |
| POLR1BRNA polymerase I subunit B | Sometimes (5–29%) | In 1 condition |
| POLR1CRNA polymerase I and III subunit C | Sometimes (5–29%) | In 1 condition |
| POLR1DRNA polymerase I and III subunit D | Sometimes (5–29%) | In 1 condition |
| PORcytochrome p450 oxidoreductase | Sometimes (5–29%) | In 1 condition |
| PPP1R15Bprotein phosphatase 1 regulatory subunit 15B | Sometimes (5–29%) | In 2 conditions |
| PTENphosphatase and tensin homolog | Sometimes (5–29%) | In 2 conditions |
| RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1 | Sometimes (5–29%) | In 1 condition |
| RPL10ribosomal protein L10 | Sometimes (5–29%) | In 2 conditions |
| RREB1ras responsive element binding protein 1 | Sometimes (5–29%) | In 1 condition |
| RTL1retrotransposon Gag like 1 | Sometimes (5–29%) | In 2 conditions |
| RTTNrotatin | Sometimes (5–29%) | In 2 conditions |
| RYR1ryanodine receptor 1 | Sometimes (5–29%) | In 2 conditions |
| SATB2SATB homeobox 2 | Sometimes (5–29%) | In 3 conditions |
| SCN1Asodium voltage-gated channel alpha subunit 1 | Sometimes (5–29%) | In 1 condition |
| SEC24CSEC24 homolog C, COPII component | Sometimes (5–29%) | In 1 condition |
| SEPTIN9septin 9 | Sometimes (5–29%) | In 2 conditions |
| SETBP1SET binding protein 1 | Sometimes (5–29%) | In 1 condition |
| SIN3ASIN3 transcription regulator family member A | Sometimes (5–29%) | In 2 conditions |
| SLC26A2solute carrier family 26 member 2 | Sometimes (5–29%) | In 1 condition |
| SMSspermine synthase | Sometimes (5–29%) | In 1 condition |
| SOX6SRY-box transcription factor 6 | Sometimes (5–29%) | In 1 condition |
| SOX9SRY-box transcription factor 9 | Sometimes (5–29%) | In 1 condition |
| SUPT16HSPT16 homolog, facilitates chromatin remodeling subunit | Sometimes (5–29%) | In 1 condition |
| SYNGAP1synaptic Ras GTPase activating protein 1 | Sometimes (5–29%) | In 1 condition |
| TAF6TATA-box binding protein associated factor 6 | Sometimes (5–29%) | In 1 condition |
| TBX1T-box transcription factor 1 | Sometimes (5–29%) | In 1 condition |
| TCOF1treacle ribosome biogenesis factor 1 | Sometimes (5–29%) | In 2 conditions |
| TGDSTDP-glucose 4,6-dehydratase | Sometimes (5–29%) | In 1 condition |
| TNNI2troponin I2, fast skeletal type | Sometimes (5–29%) | In 2 conditions |
| TNNT3troponin T3, fast skeletal type | Sometimes (5–29%) | In 2 conditions |
| TPM2tropomyosin 2 | Sometimes (5–29%) | In 2 conditions |
| TRMT10AtRNA methyltransferase 10A | Sometimes (5–29%) | In 1 condition |
| TTNtitin | Sometimes (5–29%) | In 1 condition |
| TXNL4Athioredoxin like 4A | Sometimes (5–29%) | In 1 condition |
| UFC1ubiquitin-fold modifier conjugating enzyme 1 | Sometimes (5–29%) | In 1 condition |
| UFD1ubiquitin recognition factor in ER associated degradation 1 | Sometimes (5–29%) | In 1 condition |
| H3-3AH3.3 histone A | Rarely (1–4%) | In 1 condition |
| HUWE1HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 | Rarely (1–4%) | In 1 condition |
| KIF7kinesin family member 7 | Rarely (1–4%) | In 1 condition |
| POU4F1POU class 4 homeobox 1 | Rarely (1–4%) | In 1 condition |
| RNU4-2RNA, U4 small nuclear 2 | Rarely (1–4%) | In 1 condition |
| ALDH18A1aldehyde dehydrogenase 18 family member A1 | Not recorded | In 1 condition |
| ATAD3AATPase family AAA domain containing 3A | Not recorded | In 1 condition |
| ATP6V0A2ATPase H+ transporting V0 subunit a2 | Not recorded | In 1 condition |
| BPNT23'(2'), 5'-bisphosphate nucleotidase 2 | Not recorded | In 1 condition |
| CANT1calcium activated nucleotidase 1 | Not recorded | In 1 condition |
| COL2A1collagen type II alpha 1 chain | Not recorded | In 1 condition |
| FAM20CFAM20C golgi associated secretory pathway kinase | Not recorded | In 1 condition |
| GBA1glucosylceramidase beta 1 | Not recorded | In 1 condition |
| GJA1gap junction protein alpha 1 | Not recorded | In 1 condition |
| IGF1Rinsulin like growth factor 1 receptor | Not recorded | In 1 condition |
| ITGA3integrin subunit alpha 3 | Not recorded | In 1 condition |
| MECP2methyl-CpG binding protein 2 | Not recorded | In 1 condition |
| NFIAnuclear factor I A | Not recorded | In 1 condition |
| OSGEPO-sialoglycoprotein endopeptidase | Not recorded | In 1 condition |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Not recorded | In 1 condition |
| POLD1DNA polymerase delta 1, catalytic subunit | Not recorded | In 1 condition |
| RLIMring finger protein, LIM domain interacting | Not recorded | In 1 condition |
| SKIC3SKI3 subunit of superkiller complex | Not recorded | In 1 condition |
| SLC25A24solute carrier family 25 member 24 | Not recorded | In 1 condition |
| SONSON DNA and RNA binding protein | Not recorded | In 1 condition |
| TBC1D20TBC1 domain family member 20 | Not recorded | In 1 condition |
| TLK2tousled like kinase 2 | Not recorded | In 1 condition |
| ZMIZ1zinc finger MIZ-type containing 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
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