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Trait

Duplicated collecting system

A duplication of the collecting system of the kidney, defined as a kidney with two (instead of, normally, one) pyelocaliceal systems. The pyelocaliceal system is comprised of the renal pelvis and calices. The duplicated renal collecting system can be associated with a single ureter or with double ureters. In the latter case, the two ureters empty separately into the bladder or fuse to form a single ureteral orifice.

HPO HP:0000081

Summary

Also called
Double collecting system, Double urinary collecting systems on intravenous pyelography, Duplex collecting system, Duplicated renal collecting system
Body system
Abnormality of the genitourinary system

27 genes linked to Duplicated collecting system

Changes in these genes cause rare conditions in which Duplicated collecting system is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
IARS1isoleucyl-tRNA synthetase 1AlwaysIn 2 conditions
MED16mediator complex subunit 16AlwaysIn 1 condition
PAN2poly(A) specific ribonuclease subunit PAN2AlwaysIn 1 condition
DHCR77-dehydrocholesterol reductaseOften (30–79%)In 1 condition
EMILIN1elastin microfibril interfacer 1Often (30–79%)In 1 condition
PIGAphosphatidylinositol glycan anchor biosynthesis class AOften (30–79%)In 1 condition
POGZpogo transposable element derived with ZNF domainOften (30–79%)In 2 conditions
PSMC1proteasome 26S subunit, ATPase 1Often (30–79%)In 1 condition
TNXBtenascin XBOften (30–79%)In 1 condition
KDM6Alysine demethylase 6ASometimes (5–29%)In 1 condition
KMT2Dlysine methyltransferase 2DSometimes (5–29%)In 1 condition
LAMA3laminin subunit alpha 3Sometimes (5–29%)In 1 condition
LAMB3laminin subunit beta 3Sometimes (5–29%)In 1 condition
LAMC2laminin subunit gamma 2Sometimes (5–29%)In 1 condition
MAPK1mitogen-activated protein kinase 1Sometimes (5–29%)In 1 condition
OTUD5OTU deubiquitinase 5Sometimes (5–29%)In 1 condition
SHOC2SHOC2 leucine rich repeat scaffold proteinSometimes (5–29%)In 1 condition
TELO2telomere maintenance 2Sometimes (5–29%)In 1 condition
WSB2WD repeat and SOCS box containing 2Sometimes (5–29%)In 1 condition
COL18A1collagen type XVIII alpha 1 chainRarely (1–4%)In 1 condition
JAG1jagged canonical Notch ligand 1Rarely (1–4%)In 1 condition
FANCAFA complementation group ANot recordedIn 1 condition
FANCCFA complementation group CNot recordedIn 1 condition
FANCD2FA complementation group D2Not recordedIn 1 condition
FANCEFA complementation group ENot recordedIn 1 condition
PIGLphosphatidylinositol glycan anchor biosynthesis class LNot recordedIn 1 condition
TP63tumor protein p63Not recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal renal collecting system morphology

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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