Trait
Lack of sweating
Clinical name: Anhidrosis
Inability to sweat.
Summary
- Also called
- Sweating dysfunction, Anhydrosis, Sudomotor dysfunction
- Body system
- Abnormality of the integument
Reference genomeGRCh38hg38
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Get my Genome Test38 genes linked to Lack of sweating
Changes in these genes cause rare conditions in which Lack of sweating is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ALOX12Barachidonate 12-lipoxygenase, 12R type | Always | In 1 condition |
| ALOXE3arachidonate epidermal lipoxygenase 3 | Always | In 2 conditions |
| ALPK1alpha kinase 1 | Always | In 1 condition |
| BCS1LBCS1 ubiquinol-cytochrome c reductase complex chaperone | Always | In 1 condition |
| CLDN10claudin 10 | Always | In 1 condition |
| EDARADDEDAR associated via death domain | Always | In 3 conditions |
| IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma | Always | In 1 condition |
| NTRK1neurotrophic receptor tyrosine kinase 1 | Always | In 3 conditions |
| PERPp53 apoptosis effector related to PMP22 | Always | In 2 conditions |
| PKP1plakophilin 1 | Always | In 1 condition |
| TP63tumor protein p63 | Always | In 1 condition |
| MBTPS2membrane bound transcription factor peptidase, site 2 | Very often (80–99%) | In 1 condition |
| TRPV3transient receptor potential cation channel subfamily V member 3 | Very often (80–99%) | In 1 condition |
| ALKALK receptor tyrosine kinase | Often (30–79%) | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Often (30–79%) | In 1 condition |
| NGFnerve growth factor | Often (30–79%) | In 1 condition |
| NGLY1N-glycanase 1 | Often (30–79%) | In 1 condition |
| NRASNRAS proto-oncogene, GTPase | Often (30–79%) | In 1 condition |
| RAF1Raf-1 proto-oncogene, serine/threonine kinase | Often (30–79%) | In 1 condition |
| SOX5SRY-box transcription factor 5 | Often (30–79%) | In 1 condition |
| ZEB2zinc finger E-box binding homeobox 2 | Often (30–79%) | In 1 condition |
| CAMK2Bcalcium/calmodulin dependent protein kinase II beta | Sometimes (5–29%) | In 1 condition |
| DPP9dipeptidyl peptidase 9 | Sometimes (5–29%) | In 1 condition |
| KRT14keratin 14 | Sometimes (5–29%) | In 1 condition |
| LMNB1lamin B1 | Sometimes (5–29%) | In 1 condition |
| SPTLC2serine palmitoyltransferase long chain base subunit 2 | Sometimes (5–29%) | In 1 condition |
| RYR1ryanodine receptor 1 | Rarely (1–4%) | In 1 condition |
| COQ2coenzyme Q2, polyprenyltransferase | Not recorded | In 1 condition |
| EDAectodysplasin A | Not recorded | In 1 condition |
| EDARectodysplasin A receptor | Not recorded | In 1 condition |
| ERCC6ERCC excision repair 6, chromatin remodeling factor | Not recorded | In 1 condition |
| ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit | Not recorded | In 1 condition |
| FUCA1alpha-L-fucosidase 1 | Not recorded | In 1 condition |
| KIF1Akinesin family member 1A | Not recorded | In 1 condition |
| NFKBIANFKB inhibitor alpha | Not recorded | In 1 condition |
| RETREG1reticulophagy regulator 1 | Not recorded | In 1 condition |
| SCN9Asodium voltage-gated channel alpha subunit 9 | Not recorded | In 2 conditions |
| WNK1WNK lysine deficient protein kinase 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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