Trait
Decreased size of tooth
Clinical name: Microdontia
Decreased size of the teeth, which can be defined as a mesiodistal tooth diameter (width) more than 2 SD below mean. Alternatively, an apparently decreased maximum width of tooth.
Summary
- Also called
- Decreased width of tooth, Small tooth, Small teeth, Tooth hypoplasia, Tooth hypotrophy, Underdeveloped tooth
- Body system
- Abnormality of head or neck
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Decreased size of tooth, and the rest of your genome, with one test.
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Get my Genome Test177 genes linked to Decreased size of tooth
Changes in these genes cause rare conditions in which Decreased size of tooth is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CACNA1Ccalcium voltage-gated channel subunit alpha1 C | Always | In 1 condition |
| CHSY1chondroitin sulfate synthase 1 | Always | In 2 conditions |
| EDARectodysplasin A receptor | Always | In 2 conditions |
| EDARADDEDAR associated via death domain | Always | In 3 conditions |
| FBXO28F-box protein 28 | Always | In 1 condition |
| FGF3fibroblast growth factor 3 | Always | In 2 conditions |
| GJB2gap junction protein beta 2 | Always | In 1 condition |
| HEPHL1hephaestin like 1 | Always | In 1 condition |
| HS2ST1heparan sulfate 2-O-sulfotransferase 1 | Always | In 1 condition |
| IFT140intraflagellar transport 140 | Always | In 2 conditions |
| KDM6Blysine demethylase 6B | Always | In 1 condition |
| LEF1lymphoid enhancer binding factor 1 | Always | In 1 condition |
| PIGAphosphatidylinositol glycan anchor biosynthesis class A | Always | In 2 conditions |
| PITX2paired like homeodomain 2 | Always | In 2 conditions |
| PTBP1polypyrimidine tract binding protein 1 | Always | In 1 condition |
| PYCR1pyrroline-5-carboxylate reductase 1 | Always | In 1 condition |
| RBBP8RB binding protein 8, endonuclease | Always | In 1 condition |
| RBSNrabenosyn, RAB effector | Always | In 1 condition |
| RMRPRNA component of mitochondrial RNA processing endoribonuclease | Always | In 1 condition |
| SMARCAL1SNF2 related chromatin remodeling annealing helicase 1 | Always | In 2 conditions |
| SMOC2SPARC related modular calcium binding 2 | Always | In 1 condition |
| TM2D3TM2 domain containing 3 | Always | In 1 condition |
| WDR35WD repeat domain 35 | Always | In 3 conditions |
| WDR4WDR4 tRNA N7-guanosine methyltransferase non-catalytic subunit | Always | In 1 condition |
| WNT10BWnt family member 10B | Always | In 2 conditions |
| EDAectodysplasin A | Very often (80–99%) | In 3 conditions |
| EDA2Rectodysplasin A2 receptor | Very often (80–99%) | In 1 condition |
| FGFR3fibroblast growth factor receptor 3 | Very often (80–99%) | In 2 conditions |
| GHRgrowth hormone receptor | Very often (80–99%) | In 1 condition |
| IFT122intraflagellar transport 122 | Very often (80–99%) | In 2 conditions |
| IFT43intraflagellar transport 43 | Very often (80–99%) | In 1 condition |
| IFT52intraflagellar transport 52 | Very often (80–99%) | In 1 condition |
| PIGLphosphatidylinositol glycan anchor biosynthesis class L | Very often (80–99%) | In 1 condition |
| SEC23ASEC23 homolog A, COPII component | Very often (80–99%) | In 1 condition |
| TP63tumor protein p63 | Very often (80–99%) | In 4 conditions |
| WDR19WD repeat domain 19 | Very often (80–99%) | In 1 condition |
| ARID1BAT-rich interaction domain 1B | Often (30–79%) | In 1 condition |
| B3GALT6beta-1,3-galactosyltransferase 6 | Often (30–79%) | In 1 condition |
| BAZ1Bbromodomain adjacent to zinc finger domain 1B | Often (30–79%) | In 1 condition |
| BCL11BBCL11 transcription factor B | Often (30–79%) | In 1 condition |
Show 137 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| BUD23BUD23 rRNA methyltransferase and ribosome maturation factor | Often (30–79%) | In 1 condition |
| C1Rcomplement C1r | Often (30–79%) | In 1 condition |
| C1Scomplement C1s | Often (30–79%) | In 1 condition |
| CDH3cadherin 3 | Often (30–79%) | In 2 conditions |
| CLIP2CAP-Gly domain containing linker protein 2 | Often (30–79%) | In 1 condition |
| DLX3distal-less homeobox 3 | Often (30–79%) | In 2 conditions |
| DNAJC30DnaJ heat shock protein family (Hsp40) member C30 | Often (30–79%) | In 1 condition |
| DYNC2LI1dynein cytoplasmic 2 light intermediate chain 1 | Often (30–79%) | In 1 condition |
| EIF4Heukaryotic translation initiation factor 4H | Often (30–79%) | In 1 condition |
| ELNelastin | Often (30–79%) | In 2 conditions |
| EVCEvC ciliary complex subunit 1 | Often (30–79%) | In 1 condition |
| EVC2EvC ciliary complex subunit 2 | Often (30–79%) | In 1 condition |
| FGFR1fibroblast growth factor receptor 1 | Often (30–79%) | In 1 condition |
| FGFR2fibroblast growth factor receptor 2 | Often (30–79%) | In 2 conditions |
| FKBP6FKBP prolyl isomerase family member 6 (inactive) | Often (30–79%) | In 1 condition |
| FOXC1forkhead box C1 | Often (30–79%) | In 2 conditions |
| GLI1GLI family zinc finger 1 | Often (30–79%) | In 1 condition |
| GREM2gremlin 2, DAN family BMP antagonist | Often (30–79%) | In 2 conditions |
| GTF2Igeneral transcription factor IIi | Often (30–79%) | In 1 condition |
| GTF2IRD1GTF2I repeat domain containing 1 | Often (30–79%) | In 1 condition |
| GTF2IRD2GTF2I repeat domain containing 2 | Often (30–79%) | In 1 condition |
| IRF6interferon regulatory factor 6 | Often (30–79%) | In 1 condition |
| KDM6Alysine demethylase 6A | Often (30–79%) | In 2 conditions |
| KIAA0753KIAA0753 | Often (30–79%) | In 1 condition |
| KMT2Dlysine methyltransferase 2D | Often (30–79%) | In 2 conditions |
| LAMA3laminin subunit alpha 3 | Often (30–79%) | In 1 condition |
| LIMK1LIM domain kinase 1 | Often (30–79%) | In 1 condition |
| LRP6LDL receptor related protein 6 | Often (30–79%) | In 1 condition |
| MBD5methyl-CpG binding domain protein 5 | Often (30–79%) | In 1 condition |
| MED12mediator complex subunit 12 | Often (30–79%) | In 1 condition |
| METTL27methyltransferase like 27 | Often (30–79%) | In 1 condition |
| MLXIPLMLX interacting protein like | Often (30–79%) | In 1 condition |
| MSX1msh homeobox 1 | Often (30–79%) | In 1 condition |
| NCF1neutrophil cytosolic factor 1 | Often (30–79%) | In 1 condition |
| NFIXnuclear factor I X | Often (30–79%) | In 1 condition |
| PAX9paired box 9 | Often (30–79%) | In 2 conditions |
| PCNTpericentrin | Often (30–79%) | In 2 conditions |
| PIGFphosphatidylinositol glycan anchor biosynthesis class F | Often (30–79%) | In 1 condition |
| PIK3R1phosphoinositide-3-kinase regulatory subunit 1 | Often (30–79%) | In 1 condition |
| PRKACAprotein kinase cAMP-activated catalytic subunit alpha | Often (30–79%) | In 1 condition |
| PRKACBprotein kinase cAMP-activated catalytic subunit beta | Often (30–79%) | In 1 condition |
| PRKD1protein kinase D1 | Often (30–79%) | In 1 condition |
| RFC2replication factor C subunit 2 | Often (30–79%) | In 1 condition |
| RHOAras homolog family member A | Often (30–79%) | In 1 condition |
| SRCAPSnf2 related CREBBP activator protein | Often (30–79%) | In 2 conditions |
| STX1Asyntaxin 1A | Often (30–79%) | In 1 condition |
| SUMO1small ubiquitin like modifier 1 | Often (30–79%) | In 1 condition |
| TBL2transducin beta like 2 | Often (30–79%) | In 1 condition |
| TFAP2Atranscription factor AP-2 alpha | Often (30–79%) | In 1 condition |
| TGFAtransforming growth factor alpha | Often (30–79%) | In 1 condition |
| TMEM270transmembrane protein 270 | Often (30–79%) | In 1 condition |
| TWIST2twist family bHLH transcription factor 2 | Often (30–79%) | In 1 condition |
| UBE3Bubiquitin protein ligase E3B | Often (30–79%) | In 1 condition |
| UBR1ubiquitin protein ligase E3 component n-recognin 1 | Often (30–79%) | In 1 condition |
| VPS37DVPS37D subunit of ESCRT-I | Often (30–79%) | In 1 condition |
| WNT10AWnt family member 10A | Often (30–79%) | In 1 condition |
| ADNPactivity dependent neuroprotector homeobox | Sometimes (5–29%) | In 1 condition |
| ANAPC1anaphase promoting complex subunit 1 | Sometimes (5–29%) | In 1 condition |
| ARL6ARF like GTPase 6 | Sometimes (5–29%) | In 1 condition |
| BBIP1BBSome interacting protein 1 | Sometimes (5–29%) | In 1 condition |
| BBS1Bardet-Biedl syndrome 1 | Sometimes (5–29%) | In 1 condition |
| BBS10Bardet-Biedl syndrome 10 | Sometimes (5–29%) | In 1 condition |
| BBS12Bardet-Biedl syndrome 12 | Sometimes (5–29%) | In 1 condition |
| BBS2Bardet-Biedl syndrome 2 | Sometimes (5–29%) | In 1 condition |
| BBS4Bardet-Biedl syndrome 4 | Sometimes (5–29%) | In 1 condition |
| BBS5Bardet-Biedl syndrome 5 | Sometimes (5–29%) | In 1 condition |
| BBS7Bardet-Biedl syndrome 7 | Sometimes (5–29%) | In 1 condition |
| BBS9Bardet-Biedl syndrome 9 | Sometimes (5–29%) | In 1 condition |
| CDH11cadherin 11 | Sometimes (5–29%) | In 1 condition |
| CDK13cyclin dependent kinase 13 | Sometimes (5–29%) | In 1 condition |
| CEP19centrosomal protein 19 | Sometimes (5–29%) | In 1 condition |
| CEP290centrosomal protein 290 | Sometimes (5–29%) | In 1 condition |
| CFAP418cilia and flagella associated protein 418 | Sometimes (5–29%) | In 1 condition |
| CTCFCCCTC-binding factor | Sometimes (5–29%) | In 1 condition |
| DPF2double PHD fingers 2 | Sometimes (5–29%) | In 1 condition |
| FAM20CFAM20C golgi associated secretory pathway kinase | Sometimes (5–29%) | In 1 condition |
| FGF10fibroblast growth factor 10 | Sometimes (5–29%) | In 1 condition |
| GRB10growth factor receptor bound protein 10 | Sometimes (5–29%) | In 1 condition |
| H4C5H4 clustered histone 5 | Sometimes (5–29%) | In 1 condition |
| HIVEP2HIVEP zinc finger 2 | Sometimes (5–29%) | In 1 condition |
| IFT172intraflagellar transport 172 | Sometimes (5–29%) | In 1 condition |
| IFT27intraflagellar transport 27 | Sometimes (5–29%) | In 1 condition |
| IFT74intraflagellar transport 74 | Sometimes (5–29%) | In 1 condition |
| IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma | Sometimes (5–29%) | In 1 condition |
| ITPR3inositol 1,4,5-trisphosphate receptor type 3 | Sometimes (5–29%) | In 1 condition |
| KCTD1potassium channel tetramerization domain containing 1 | Sometimes (5–29%) | In 1 condition |
| LMBRD2LMBR1 domain containing 2 | Sometimes (5–29%) | In 1 condition |
| LZTFL1leucine zipper transcription factor like 1 | Sometimes (5–29%) | In 1 condition |
| MAPK1mitogen-activated protein kinase 1 | Sometimes (5–29%) | In 1 condition |
| MAPRE2microtubule associated protein RP/EB family member 2 | Sometimes (5–29%) | In 1 condition |
| MAU2MAU2 sister chromatid cohesion factor | Sometimes (5–29%) | In 1 condition |
| MCOLN1mucolipin TRP cation channel 1 | Sometimes (5–29%) | In 1 condition |
| MKKSMKKS centrosomal shuttling protein | Sometimes (5–29%) | In 1 condition |
| MKS1MKS transition zone complex subunit 1 | Sometimes (5–29%) | In 1 condition |
| NPHP1nephrocystin 1 | Sometimes (5–29%) | In 1 condition |
| PIK3C2Aphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha | Sometimes (5–29%) | In 1 condition |
| PLXNA1plexin A1 | Sometimes (5–29%) | In 1 condition |
| PLXND1plexin D1 | Sometimes (5–29%) | In 1 condition |
| PRIM1DNA primase subunit 1 | Sometimes (5–29%) | In 1 condition |
| RECQL4RecQ like helicase 4 | Sometimes (5–29%) | In 2 conditions |
| REV3LREV3 like, DNA directed polymerase zeta catalytic subunit | Sometimes (5–29%) | In 1 condition |
| SATB2SATB homeobox 2 | Sometimes (5–29%) | In 1 condition |
| SCAPERS-phase cyclin A associated protein in the ER | Sometimes (5–29%) | In 1 condition |
| SCLT1sodium channel and clathrin linker 1 | Sometimes (5–29%) | In 1 condition |
| SCNM1sodium channel modifier 1 | Sometimes (5–29%) | In 1 condition |
| SDCCAG8SHH signaling and ciliogenesis regulator SDCCAG8 | Sometimes (5–29%) | In 1 condition |
| SMARCA2SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2 | Sometimes (5–29%) | In 1 condition |
| SMC3structural maintenance of chromosomes 3 | Sometimes (5–29%) | In 1 condition |
| TCF12transcription factor 12 | Sometimes (5–29%) | In 1 condition |
| TONSLtonsoku like, DNA repair protein | Sometimes (5–29%) | In 1 condition |
| TRIM32tripartite motif containing 32 | Sometimes (5–29%) | In 1 condition |
| TTC8tetratricopeptide repeat domain 8 | Sometimes (5–29%) | In 1 condition |
| WDPCPWD repeat containing planar cell polarity effector | Sometimes (5–29%) | In 1 condition |
| ZFXzinc finger protein X-linked | Sometimes (5–29%) | In 1 condition |
| CNTNAP2contactin associated protein 2 | Rarely (1–4%) | In 1 condition |
| GJA5gap junction protein alpha 5 | Rarely (1–4%) | In 1 condition |
| GJA8gap junction protein alpha 8 | Rarely (1–4%) | In 1 condition |
| ATP6V0A2ATPase H+ transporting V0 subunit a2 | Not recorded | In 1 condition |
| B3GAT3beta-1,3-glucuronyltransferase 3 | Not recorded | In 1 condition |
| CCDC47coiled-coil domain containing 47 | Not recorded | In 1 condition |
| CHST3carbohydrate sulfotransferase 3 | Not recorded | In 2 conditions |
| CKAP2Lcytoskeleton associated protein 2L | Not recorded | In 1 condition |
| DNAJC21DnaJ heat shock protein family (Hsp40) member C21 | Not recorded | In 1 condition |
| EYA1EYA transcriptional coactivator and phosphatase 1 | Not recorded | In 1 condition |
| GJA1gap junction protein alpha 1 | Not recorded | In 1 condition |
| IDUAalpha-L-iduronidase | Not recorded | In 1 condition |
| KAT6Blysine acetyltransferase 6B | Not recorded | In 1 condition |
| LTBP3latent transforming growth factor beta binding protein 3 | Not recorded | In 1 condition |
| NECTIN1nectin cell adhesion molecule 1 | Not recorded | In 1 condition |
| NHP2NHP2 ribonucleoprotein | Not recorded | In 1 condition |
| NOP10NOP10 ribonucleoprotein | Not recorded | In 1 condition |
| ORC1origin recognition complex subunit 1 | Not recorded | In 1 condition |
| P4HBprolyl 4-hydroxylase subunit beta | Not recorded | In 1 condition |
| PCGF2polycomb group ring finger 2 | Not recorded | In 1 condition |
| SIX1SIX homeobox 1 | Not recorded | In 1 condition |
| SLC25A24solute carrier family 25 member 24 | Not recorded | In 1 condition |
| TRPS1transcriptional repressor GATA binding 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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