Trait

Damage to outer layer of the cornea of the eye

Clinical name: Corneal erosion

An erosion or abrasion of the cornea's outermost layer of epithelial cells.

HPO HP:0200020

Body system: Abnormality of the eye

This page as data

Add .json to the page's address, or ask for application/json, to read it as JSON.

library(jsonlite)

url <- "https://dantelabs.com/traits/corneal-erosion.json"
page <- fromJSON(url)
page$trait$name

Open the JSON

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39 genes linked to Damage to outer layer of the cornea of the eye

Changes in these genes cause rare conditions in which Damage to outer layer of the cornea of the eye is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
DHRSXdehydrogenase/reductase X-linked	Always	In 1 condition
PAX6paired box 6	Always	In 1 condition
TGFBItransforming growth factor beta induced	Always	In 2 conditions
WT1WT1 transcription factor	Always	In 1 condition
FOXC2forkhead box C2	Very often (80–99%)	In 1 condition
ABCA12ATP binding cassette subfamily A member 12	Often (30–79%)	In 1 condition
ALOX12Barachidonate 12-lipoxygenase, 12R type	Often (30–79%)	In 1 condition
ALOXE3arachidonate epidermal lipoxygenase 3	Often (30–79%)	In 1 condition
CERS3ceramide synthase 3	Often (30–79%)	In 1 condition
ELP1elongator acetyltransferase complex subunit 1	Often (30–79%)	In 1 condition
GJB2gap junction protein beta 2	Often (30–79%)	In 1 condition
GJB6gap junction protein beta 6	Often (30–79%)	In 1 condition
LAMA3laminin subunit alpha 3	Often (30–79%)	In 1 condition
MBTPS2membrane bound transcription factor peptidase, site 2	Often (30–79%)	In 1 condition
NIPAL4NIPA like domain containing 4	Often (30–79%)	In 1 condition
PLCG2phospholipase C gamma 2	Often (30–79%)	In 1 condition
PNPLA1patatin like domain 1, omega-hydroxyceramide transacylase	Often (30–79%)	In 1 condition
SDR9C7short chain dehydrogenase/reductase family 9C member 7	Often (30–79%)	In 1 condition
SPINT2serine peptidase inhibitor, Kunitz type 2	Often (30–79%)	In 1 condition
SULT2B1sulfotransferase family 2B member 1	Often (30–79%)	In 1 condition
TGM1transglutaminase 1	Often (30–79%)	In 1 condition
TP63tumor protein p63	Often (30–79%)	In 1 condition
CLTCL1clathrin heavy chain like 1	Sometimes (5–29%)	In 1 condition
COL7A1collagen type VII alpha 1 chain	Sometimes (5–29%)	In 2 conditions
EPCAMepithelial cell adhesion molecule	Sometimes (5–29%)	In 1 condition
FGFR2fibroblast growth factor receptor 2	Sometimes (5–29%)	In 1 condition
HLA-Bmajor histocompatibility complex, class I, B	Sometimes (5–29%)	In 1 condition
IKZF1IKAROS family zinc finger 1	Sometimes (5–29%)	In 1 condition
MMP1matrix metallopeptidase 1	Sometimes (5–29%)	In 1 condition
PRDM5PR/SET domain 5	Sometimes (5–29%)	In 1 condition
SLC39A4solute carrier family 39 member 4	Sometimes (5–29%)	In 1 condition
TWIST2twist family bHLH transcription factor 2	Sometimes (5–29%)	In 1 condition
ZNF469zinc finger protein 469	Sometimes (5–29%)	In 1 condition
COL17A1collagen type XVII alpha 1 chain	Not recorded	In 1 condition
COL4A3collagen type IV alpha 3 chain	Not recorded	In 1 condition
COL4A4collagen type IV alpha 4 chain	Not recorded	In 2 conditions
COL4A5collagen type IV alpha 5 chain	Not recorded	In 1 condition
FERMT1FERM domain containing kindlin 1	Not recorded	In 1 condition
KIFBPkinesin family binding protein	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Abnormal corneal epithelium morphology

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.17-8666dff2.

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