Trait
Wide-spaced nipples
Clinical name: Wide intermamillary distance
A larger than usual distance between the left and right nipple.
Summary
- Also called
- Widely spaced nipples, Widely-spaced nipples
- Body system
- Abnormality of the breast
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Wide-spaced nipples, and the rest of your genome, with one test.
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Get my Genome Test134 genes linked to Wide-spaced nipples
Changes in these genes cause rare conditions in which Wide-spaced nipples is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ALPK3alpha kinase 3 | Always | In 1 condition |
| ASH1LASH1 like histone lysine methyltransferase | Always | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Always | In 3 conditions |
| CACHD1cache domain containing 1 | Always | In 1 condition |
| CDH11cadherin 11 | Always | In 1 condition |
| EEDembryonic ectoderm development | Always | In 1 condition |
| GPC3glypican 3 | Always | In 1 condition |
| KAT6Alysine acetyltransferase 6A | Always | In 1 condition |
| NSD2nuclear receptor binding SET domain protein 2 | Always | In 1 condition |
| NUP188nucleoporin 188 | Always | In 1 condition |
| PPP1CBprotein phosphatase 1 catalytic subunit beta | Always | In 1 condition |
| SMSspermine synthase | Always | In 2 conditions |
| SOS1SOS Ras/Rac guanine nucleotide exchange factor 1 | Always | In 2 conditions |
| SPIN4spindlin family member 4 | Always | In 1 condition |
| TAF4TATA-box binding protein associated factor 4 | Always | In 1 condition |
| TIMM50translocase of inner mitochondrial membrane 50 | Always | In 1 condition |
| CBLCbl proto-oncogene | Very often (80–99%) | In 2 conditions |
| CHD7chromodomain helicase DNA binding protein 7 | Very often (80–99%) | In 1 condition |
| DUSP6dual specificity phosphatase 6 | Very often (80–99%) | In 1 condition |
| EMX2empty spiracles homeobox 2 | Very often (80–99%) | In 1 condition |
| FGF17fibroblast growth factor 17 | Very often (80–99%) | In 1 condition |
| FGF8fibroblast growth factor 8 | Very often (80–99%) | In 1 condition |
| FGFR1fibroblast growth factor receptor 1 | Very often (80–99%) | In 1 condition |
| GNRH1gonadotropin releasing hormone 1 | Very often (80–99%) | In 1 condition |
| GNRHRgonadotropin releasing hormone receptor | Very often (80–99%) | In 1 condition |
| HS6ST1heparan sulfate 6-O-sulfotransferase 1 | Very often (80–99%) | In 1 condition |
| KISS1KiSS-1 metastasis suppressor | Very often (80–99%) | In 1 condition |
| KISS1RKISS1 receptor | Very often (80–99%) | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Very often (80–99%) | In 1 condition |
| LZTR1leucine zipper like post translational regulator 1 | Very often (80–99%) | In 2 conditions |
| MEGF8multiple EGF like domains 8 | Very often (80–99%) | In 1 condition |
| MRASmuscle RAS oncogene homolog | Very often (80–99%) | In 1 condition |
| NHLH2nescient helix-loop-helix 2 | Very often (80–99%) | In 1 condition |
| NRASNRAS proto-oncogene, GTPase | Very often (80–99%) | In 1 condition |
| NSMFNMDA receptor synaptonuclear signaling and neuronal migration factor | Very often (80–99%) | In 1 condition |
| PROK2prokineticin 2 | Very often (80–99%) | In 1 condition |
| PROKR2prokineticin receptor 2 | Very often (80–99%) | In 1 condition |
| PTPN11protein tyrosine phosphatase non-receptor type 11 | Very often (80–99%) | In 2 conditions |
| RAF1Raf-1 proto-oncogene, serine/threonine kinase | Very often (80–99%) | In 1 condition |
| RASA2RAS p21 protein activator 2 | Very often (80–99%) | In 1 condition |
Show 94 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| RIT1Ras like without CAAX 1 | Very often (80–99%) | In 1 condition |
| RRASRAS related | Very often (80–99%) | In 1 condition |
| RRAS2RAS related 2 | Very often (80–99%) | In 1 condition |
| SOS2SOS Ras/Rho guanine nucleotide exchange factor 2 | Very often (80–99%) | In 1 condition |
| SPRED2sprouty related EVH1 domain containing 2 | Very often (80–99%) | In 1 condition |
| SPRY4sprouty RTK signaling antagonist 4 | Very often (80–99%) | In 1 condition |
| TAC3tachykinin precursor 3 | Very often (80–99%) | In 1 condition |
| TACR3tachykinin receptor 3 | Very often (80–99%) | In 1 condition |
| TBL1XR1TBL1X/Y related 1 | Very often (80–99%) | In 2 conditions |
| UBE2Aubiquitin conjugating enzyme E2 A | Very often (80–99%) | In 2 conditions |
| WDR11WD repeat domain 11 | Very often (80–99%) | In 1 condition |
| ABCD4ATP binding cassette subfamily D member 4 | Often (30–79%) | In 1 condition |
| AMMECR1AMMECR nuclear protein 1 | Often (30–79%) | In 1 condition |
| ARHGEF2Rho/Rac guanine nucleotide exchange factor 2 | Often (30–79%) | In 1 condition |
| BCL11ABCL11 transcription factor A | Often (30–79%) | In 1 condition |
| CERT1ceramide transporter 1 | Often (30–79%) | In 1 condition |
| COG1component of oligomeric golgi complex 1 | Often (30–79%) | In 1 condition |
| DHCR77-dehydrocholesterol reductase | Often (30–79%) | In 1 condition |
| EXOC2exocyst complex component 2 | Often (30–79%) | In 1 condition |
| EXTL3exostosin like glycosyltransferase 3 | Often (30–79%) | In 1 condition |
| FGFR2fibroblast growth factor receptor 2 | Often (30–79%) | In 1 condition |
| GATA4GATA binding protein 4 | Often (30–79%) | In 1 condition |
| HDAC4histone deacetylase 4 | Often (30–79%) | In 1 condition |
| HNRNPKheterogeneous nuclear ribonucleoprotein K | Often (30–79%) | In 1 condition |
| IBA57iron-sulfur cluster assembly factor IBA57 | Often (30–79%) | In 1 condition |
| IGF1Rinsulin like growth factor 1 receptor | Often (30–79%) | In 2 conditions |
| KNSTRNkinetochore localized astrin (SPAG5) binding protein | Often (30–79%) | In 1 condition |
| LAMA5laminin subunit alpha 5 | Often (30–79%) | In 1 condition |
| LBRlamin B receptor | Often (30–79%) | In 1 condition |
| MAP2K1mitogen-activated protein kinase kinase 1 | Often (30–79%) | In 1 condition |
| MGAT2alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | Often (30–79%) | In 1 condition |
| NECTIN1nectin cell adhesion molecule 1 | Often (30–79%) | In 1 condition |
| PIGNphosphatidylinositol glycan anchor biosynthesis class N | Often (30–79%) | In 1 condition |
| PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta | Often (30–79%) | In 1 condition |
| PSAT1phosphoserine aminotransferase 1 | Often (30–79%) | In 1 condition |
| RELREL proto-oncogene, NF-kB subunit | Often (30–79%) | In 1 condition |
| RIPK4receptor interacting serine/threonine kinase 4 | Often (30–79%) | In 1 condition |
| SMARCA2SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2 | Often (30–79%) | In 1 condition |
| TOGARAM1TOG array regulator of axonemal microtubules 1 | Often (30–79%) | In 1 condition |
| TRAF7TNF receptor associated factor 7 | Often (30–79%) | In 1 condition |
| TSHZ3teashirt zinc finger homeobox 3 | Often (30–79%) | In 1 condition |
| TTC5tetratricopeptide repeat domain 5 | Often (30–79%) | In 1 condition |
| TUBBtubulin beta class I | Often (30–79%) | In 1 condition |
| WASF1WASP family member 1 | Often (30–79%) | In 1 condition |
| WDR37WD repeat domain 37 | Often (30–79%) | In 1 condition |
| WLSWnt ligand secretion mediator | Often (30–79%) | In 1 condition |
| XPO1exportin 1 | Often (30–79%) | In 1 condition |
| ADNPactivity dependent neuroprotector homeobox | Sometimes (5–29%) | In 1 condition |
| AHDC1AT-hook DNA binding motif containing 1 | Sometimes (5–29%) | In 1 condition |
| ALG14ALG14 UDP-N-acetylglucosaminyltransferase subunit | Sometimes (5–29%) | In 1 condition |
| ALG9ALG9 alpha-1,2-mannosyltransferase | Sometimes (5–29%) | In 1 condition |
| B3GLCTbeta 3-glucosyltransferase | Sometimes (5–29%) | In 2 conditions |
| CDK13cyclin dependent kinase 13 | Sometimes (5–29%) | In 1 condition |
| CILK1ciliogenesis associated kinase 1 | Sometimes (5–29%) | In 1 condition |
| COX7Bcytochrome c oxidase subunit 7B | Sometimes (5–29%) | In 1 condition |
| CSPP1centrosome and spindle pole associated protein 1 | Sometimes (5–29%) | In 1 condition |
| DLK1delta like non-canonical Notch ligand 1 | Sometimes (5–29%) | In 1 condition |
| ERMARDER membrane associated RNA degradation | Sometimes (5–29%) | In 1 condition |
| FRAS1Fraser extracellular matrix complex subunit 1 | Sometimes (5–29%) | In 2 conditions |
| FREM2FRAS1 related extracellular matrix 2 | Sometimes (5–29%) | In 1 condition |
| GNB2G protein subunit beta 2 | Sometimes (5–29%) | In 1 condition |
| GRIP1glutamate receptor interacting protein 1 | Sometimes (5–29%) | In 1 condition |
| IDH1isocitrate dehydrogenase (NADP(+)) 1 | Sometimes (5–29%) | In 1 condition |
| KATNB1katanin regulatory subunit B1 | Sometimes (5–29%) | In 1 condition |
| KIAA0586KIAA0586 | Sometimes (5–29%) | In 1 condition |
| MAB21L1mab-21 like 1 | Sometimes (5–29%) | In 2 conditions |
| MADDMAP kinase activating death domain | Sometimes (5–29%) | In 1 condition |
| MAPRE2microtubule associated protein RP/EB family member 2 | Sometimes (5–29%) | In 1 condition |
| MEG3maternally expressed 3 | Sometimes (5–29%) | In 1 condition |
| MSL2MSL complex subunit 2 | Sometimes (5–29%) | In 1 condition |
| PACS1phosphofurin acidic cluster sorting protein 1 | Sometimes (5–29%) | In 2 conditions |
| RPL17ribosomal protein L17 | Sometimes (5–29%) | In 1 condition |
| RTL1retrotransposon Gag like 1 | Sometimes (5–29%) | In 1 condition |
| SRYsex determining region Y | Sometimes (5–29%) | In 1 condition |
| TMEM94transmembrane protein 94 | Sometimes (5–29%) | In 1 condition |
| WSB2WD repeat and SOCS box containing 2 | Sometimes (5–29%) | In 1 condition |
| ZNF148zinc finger protein 148 | Sometimes (5–29%) | In 1 condition |
| NF1neurofibromin 1 | Rarely (1–4%) | In 1 condition |
| SMPD4sphingomyelin phosphodiesterase 4 | Rarely (1–4%) | In 1 condition |
| AMER1APC membrane recruitment protein 1 | Not recorded | In 1 condition |
| ARCN1archain 1 coat protein complex I subunit delta | Not recorded | In 1 condition |
| ASXL1ASXL transcriptional regulator 1 | Not recorded | In 1 condition |
| CHST3carbohydrate sulfotransferase 3 | Not recorded | In 1 condition |
| CPT2carnitine palmitoyltransferase 2 | Not recorded | In 1 condition |
| ERCC6ERCC excision repair 6, chromatin remodeling factor | Not recorded | In 1 condition |
| GNPTABN-acetylglucosamine-1-phosphate transferase subunits alpha and beta | Not recorded | In 1 condition |
| INTUinturned planar cell polarity protein | Not recorded | In 1 condition |
| KANSL1KAT8 regulatory NSL complex subunit 1 | Not recorded | In 1 condition |
| KIFBPkinesin family binding protein | Not recorded | In 1 condition |
| RAB18RAB18, member RAS oncogene family | Not recorded | In 1 condition |
| TFAP2Atranscription factor AP-2 alpha | Not recorded | In 1 condition |
| TMCO1transmembrane and coiled-coil domains 1 | Not recorded | In 1 condition |
| TP63tumor protein p63 | Not recorded | In 1 condition |
| ZC4H2zinc finger C4H2-type containing | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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