Gene
CYP19A1
cytochrome P450 family 19 subfamily A member 1
- HGNC 2594(opens in a new tab)
- Ensembl gene ENSG00000137869(opens in a new tab)
- NCBI Gene 1588(opens in a new tab)
Summary
- Cytogenetic location
- 15q21.2
- Coordinates
- Chromosome 15: 51,208,057–51,338,596 (GRCh38)
- Exons
- 10 exons across 130.5 kb
- Protein
- 503 amino acids
- Also known as
- ARO, P-450AROM, CPV1, ARO1, CYAR, aromatase
- Previous symbols
- CYP19
- MANE Select transcript
- ENST00000396402.6NM_000103.4
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Female Infertility
Diminished or absent ability of a female to achieve conception.
- 3 GenCC submitters rate it definitive or strong
How CYP19A1 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 4.4 kb of the gene's 130.5 kb; 1,512 of those bases code for the protein.
How a genome test reads CYP19A1
44
positions in CYP19A1 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 130.5 kb of CYP19A1, introns included, not only the 4.4 kb of exons.
Traits linked to CYP19A1
The Human Phenotype Ontology lists these as features of the rare conditions CYP19A1 can cause. Each trait's page lists the other genes linked to it.
Abnormality of the endocrine system
- Hypergonadotropic hypogonadism
- Increased serum estrone
- Decreased circulating follicle stimulating hormone concentration
- Hypogonadotropic hypogonadism
- Increased serum estradiol
- Decreased function of male gonad
- Decreased serum testosterone level
- Precocious puberty in females
Show 1 more trait
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
- The ACMG secondary findings list, SF v3.2.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). CYP19A1 gene: cytochrome P450 family 19 subfamily A member 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/cyp19a1
Dante Labs. CYP19A1 gene: cytochrome P450 family 19 subfamily A member 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/cyp19a1
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