Trait
Poor nail formation
Clinical name: Nail dystrophy
Onychodystrophy (nail dystrophy) refers to nail changes apart from changes of the color (nail dyschromia) and involves partial or complete disruption of the various keratinous layers of the nail plate.
Summary
- Also called
- Dystrophic nails, Onychodystrophy
- Body system
- Abnormality of the integument
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Poor nail formation, and the rest of your genome, with one test.
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Get my Genome Test130 genes linked to Poor nail formation
Changes in these genes cause rare conditions in which Poor nail formation is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ATP6V1B2ATPase H+ transporting V1 subunit B2 | Always | In 1 condition |
| COL17A1collagen type XVII alpha 1 chain | Always | In 5 conditions |
| COL7A1collagen type VII alpha 1 chain | Always | In 13 conditions |
| DKC1dyskerin pseudouridine synthase 1 | Always | In 3 conditions |
| DSG1desmoglein 1 | Always | In 1 condition |
| GRHL2grainyhead like transcription factor 2 | Always | In 1 condition |
| HOXC13homeobox C13 | Always | In 1 condition |
| ITGA3integrin subunit alpha 3 | Always | In 1 condition |
| ITGB4integrin subunit beta 4 | Always | In 6 conditions |
| KRT14keratin 14 | Always | In 7 conditions |
| KRT16keratin 16 | Always | In 2 conditions |
| KRT17keratin 17 | Always | In 2 conditions |
| KRT5keratin 5 | Always | In 7 conditions |
| KRT6Akeratin 6A | Always | In 3 conditions |
| KRT6Bkeratin 6B | Always | In 3 conditions |
| KRT85keratin 85 | Always | In 1 condition |
| LAMA3laminin subunit alpha 3 | Always | In 5 conditions |
| LAMB3laminin subunit beta 3 | Always | In 4 conditions |
| MARS1methionyl-tRNA synthetase 1 | Always | In 1 condition |
| MPLKIPM-phase specific PLK1 interacting protein | Always | In 1 condition |
| NHEJ1non-homologous end joining factor 1 | Always | In 1 condition |
| NHP2NHP2 ribonucleoprotein | Always | In 3 conditions |
| NLRP1NLR family pyrin domain containing 1 | Always | In 1 condition |
| NOP10NOP10 ribonucleoprotein | Always | In 2 conditions |
| PKP1plakophilin 1 | Always | In 2 conditions |
| PLECplectin | Always | In 4 conditions |
| RNU6ATACRNA, U6atac small nuclear | Always | In 1 condition |
| SASH1SAM and SH3 domain containing 1 | Always | In 1 condition |
| STING1stimulator of interferon response cGAMP interactor 1 | Always | In 1 condition |
| TINF2TERF1 interacting nuclear factor 2 | Always | In 6 conditions |
| TP63tumor protein p63 | Always | In 4 conditions |
| TYMSthymidylate synthetase | Always | In 2 conditions |
| WNT10AWnt family member 10A | Always | In 1 condition |
| WRAP53WD repeat containing antisense to TP53 | Always | In 2 conditions |
| WRNWRN RecQ like helicase | Always | In 1 condition |
| ABCA12ATP binding cassette subfamily A member 12 | Very often (80–99%) | In 1 condition |
| ACDACD shelterin complex subunit and telomerase recruitment factor | Very often (80–99%) | In 3 conditions |
| ALOX12Barachidonate 12-lipoxygenase, 12R type | Very often (80–99%) | In 1 condition |
| ALOXE3arachidonate epidermal lipoxygenase 3 | Very often (80–99%) | In 1 condition |
| ASPRV1aspartic peptidase retroviral like 1 | Very often (80–99%) | In 1 condition |
Show 90 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| ATP2A2ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 | Very often (80–99%) | In 1 condition |
| CTC1CST telomere replication complex component 1 | Very often (80–99%) | In 2 conditions |
| CTNNB1catenin beta 1 | Very often (80–99%) | In 1 condition |
| CYP4F22cytochrome P450 family 4 subfamily F member 22 | Very often (80–99%) | In 1 condition |
| DNA2DNA replication helicase/nuclease 2 | Very often (80–99%) | In 1 condition |
| EVCEvC ciliary complex subunit 1 | Very often (80–99%) | In 1 condition |
| EVC2EvC ciliary complex subunit 2 | Very often (80–99%) | In 1 condition |
| GJA1gap junction protein alpha 1 | Very often (80–99%) | In 1 condition |
| KDF1keratinocyte differentiation factor 1 | Very often (80–99%) | In 1 condition |
| LIPNlipase family member N | Very often (80–99%) | In 1 condition |
| LSSlanosterol synthase | Very often (80–99%) | In 1 condition |
| NIPAL4NIPA like domain containing 4 | Very often (80–99%) | In 1 condition |
| NPM1nucleophosmin 1 | Very often (80–99%) | In 1 condition |
| PARNpoly(A)-specific ribonuclease | Very often (80–99%) | In 3 conditions |
| PORCNporcupine O-acyltransferase | Very often (80–99%) | In 2 conditions |
| RTEL1regulator of telomere elongation helicase 1 | Very often (80–99%) | In 3 conditions |
| SDR9C7short chain dehydrogenase/reductase family 9C member 7 | Very often (80–99%) | In 1 condition |
| SULT2B1sulfotransferase family 2B member 1 | Very often (80–99%) | In 1 condition |
| TERCtelomerase RNA component | Very often (80–99%) | In 3 conditions |
| TERTtelomerase reverse transcriptase | Very often (80–99%) | In 4 conditions |
| TGM1transglutaminase 1 | Very often (80–99%) | In 3 conditions |
| USB1U6 snRNA biogenesis phosphodiesterase 1 | Very often (80–99%) | In 2 conditions |
| ABCA1ATP binding cassette subfamily A member 1 | Often (30–79%) | In 2 conditions |
| AIREautoimmune regulator | Often (30–79%) | In 2 conditions |
| BANF1barrier to autointegration nuclear assembly factor 1 | Often (30–79%) | In 1 condition |
| CD28CD28 molecule | Often (30–79%) | In 1 condition |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Often (30–79%) | In 1 condition |
| CTSCcathepsin C | Often (30–79%) | In 1 condition |
| DCLRE1BDNA cross-link repair 1B | Often (30–79%) | In 1 condition |
| DSPdesmoplakin | Often (30–79%) | In 2 conditions |
| FOXN1forkhead box N1 | Often (30–79%) | In 2 conditions |
| GJB2gap junction protein beta 2 | Often (30–79%) | In 2 conditions |
| GJB6gap junction protein beta 6 | Often (30–79%) | In 3 conditions |
| IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma | Often (30–79%) | In 3 conditions |
| KRT1keratin 1 | Often (30–79%) | In 1 condition |
| LAMC2laminin subunit gamma 2 | Often (30–79%) | In 3 conditions |
| MMP1matrix metallopeptidase 1 | Often (30–79%) | In 1 condition |
| NECTIN1nectin cell adhesion molecule 1 | Often (30–79%) | In 1 condition |
| NFKB2nuclear factor kappa B subunit 2 | Often (30–79%) | In 1 condition |
| POLD3DNA polymerase delta 3, accessory subunit | Often (30–79%) | In 1 condition |
| PQBP1polyglutamine binding protein 1 | Often (30–79%) | In 1 condition |
| RBCK1RANBP2-type and C3HC4-type zinc finger containing 1 | Often (30–79%) | In 1 condition |
| RECQL4RecQ like helicase 4 | Often (30–79%) | In 1 condition |
| TNFRSF1BTNF receptor superfamily member 1B | Often (30–79%) | In 1 condition |
| UBE2Aubiquitin conjugating enzyme E2 A | Often (30–79%) | In 2 conditions |
| ZMPSTE24zinc metallopeptidase STE24 | Often (30–79%) | In 1 condition |
| ANAPC1anaphase promoting complex subunit 1 | Sometimes (5–29%) | In 1 condition |
| ATRATR checkpoint kinase | Sometimes (5–29%) | In 1 condition |
| CDSNcorneodesmosin | Sometimes (5–29%) | In 1 condition |
| COX7Bcytochrome c oxidase subunit 7B | Sometimes (5–29%) | In 1 condition |
| CSTAcystatin A | Sometimes (5–29%) | In 1 condition |
| FGFR2fibroblast growth factor receptor 2 | Sometimes (5–29%) | In 1 condition |
| FOCADfocadhesin | Sometimes (5–29%) | In 1 condition |
| FOXP3forkhead box P3 | Sometimes (5–29%) | In 1 condition |
| GABBR1gamma-aminobutyric acid type B receptor subunit 1 | Sometimes (5–29%) | In 1 condition |
| IL36RNinterleukin 36 receptor antagonist | Sometimes (5–29%) | In 1 condition |
| ITGA6integrin subunit alpha 6 | Sometimes (5–29%) | In 2 conditions |
| KIF15kinesin family member 15 | Sometimes (5–29%) | In 1 condition |
| KMT2Dlysine methyltransferase 2D | Sometimes (5–29%) | In 1 condition |
| LORICRINloricrin cornified envelope precursor protein | Sometimes (5–29%) | In 1 condition |
| LRP1LDL receptor related protein 1 | Sometimes (5–29%) | In 1 condition |
| MAFMAF bZIP transcription factor | Sometimes (5–29%) | In 1 condition |
| MBTPS2membrane bound transcription factor peptidase, site 2 | Sometimes (5–29%) | In 3 conditions |
| MTX2metaxin 2 | Sometimes (5–29%) | In 1 condition |
| MVKmevalonate kinase | Sometimes (5–29%) | In 1 condition |
| NAF1nuclear assembly factor 1 ribonucleoprotein | Sometimes (5–29%) | In 1 condition |
| NFKBIANFKB inhibitor alpha | Sometimes (5–29%) | In 1 condition |
| PPP1R13Lprotein phosphatase 1 regulatory subunit 13 like | Sometimes (5–29%) | In 1 condition |
| RPA1replication protein A1 | Sometimes (5–29%) | In 1 condition |
| SAT1spermidine/spermine N1-acetyltransferase 1 | Sometimes (5–29%) | In 1 condition |
| SEL1LSEL1L adaptor subunit of SYVN1 ubiquitin ligase | Sometimes (5–29%) | In 1 condition |
| SMARCAD1SNF2 related chromatin remodeling ATPase with DExD box 1 | Sometimes (5–29%) | In 2 conditions |
| SREBF1sterol regulatory element binding transcription factor 1 | Sometimes (5–29%) | In 2 conditions |
| AAGABalpha and gamma adaptin binding protein | Rarely (1–4%) | In 1 condition |
| COL14A1collagen type XIV alpha 1 chain | Rarely (1–4%) | In 1 condition |
| GSNgelsolin | Rarely (1–4%) | In 1 condition |
| PI4KAphosphatidylinositol 4-kinase alpha | Rarely (1–4%) | In 1 condition |
| TTC7Atetratricopeptide repeat domain 7A | Rarely (1–4%) | In 1 condition |
| AP1S3adaptor related protein complex 1 subunit sigma 3 | Not recorded | In 1 condition |
| ATL1atlastin GTPase 1 | Not recorded | In 1 condition |
| CD151CD151 molecule (Raph blood group) | Not recorded | In 1 condition |
| DNAJC21DnaJ heat shock protein family (Hsp40) member C21 | Not recorded | In 1 condition |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Not recorded | In 1 condition |
| FLNAfilamin A | Not recorded | In 1 condition |
| JUPjunction plakoglobin | Not recorded | In 1 condition |
| KRT86keratin 86 | Not recorded | In 1 condition |
| NTRK1neurotrophic receptor tyrosine kinase 1 | Not recorded | In 1 condition |
| POMPproteasome maturation protein | Not recorded | In 1 condition |
| RSPO1R-spondin 1 | Not recorded | In 1 condition |
| TRPV3transient receptor potential cation channel subfamily V member 3 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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