Trait
Narrowing of anal opening
Clinical name: Anal stenosis
Abnormal narrowing of the anal opening.
Summary
- Body system
- Abnormality of the digestive system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test32 genes linked to Narrowing of anal opening
Changes in these genes cause rare conditions in which Narrowing of anal opening is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CACNA1Ccalcium voltage-gated channel subunit alpha1 C | Always | In 1 condition |
| HES7hes family bHLH transcription factor 7 | Always | In 1 condition |
| FREM1FRAS1 related extracellular matrix 1 | Very often (80–99%) | In 3 conditions |
| NBNnibrin | Very often (80–99%) | In 2 conditions |
| FRAS1Fraser extracellular matrix complex subunit 1 | Often (30–79%) | In 1 condition |
| FREM2FRAS1 related extracellular matrix 2 | Often (30–79%) | In 1 condition |
| GRIP1glutamate receptor interacting protein 1 | Often (30–79%) | In 1 condition |
| MNX1motor neuron and pancreas homeobox 1 | Often (30–79%) | In 2 conditions |
| PGAP2post-GPI attachment to proteins 2 | Often (30–79%) | In 1 condition |
| PIGOphosphatidylinositol glycan anchor biosynthesis class O | Often (30–79%) | In 1 condition |
| RIPK4receptor interacting serine/threonine kinase 4 | Often (30–79%) | In 1 condition |
| TP63tumor protein p63 | Often (30–79%) | In 1 condition |
| CDC45cell division cycle 45 | Sometimes (5–29%) | In 1 condition |
| DCHS1dachsous cadherin-related 1 | Sometimes (5–29%) | In 1 condition |
| FAT4FAT atypical cadherin 4 | Sometimes (5–29%) | In 1 condition |
| FERMT1FERM domain containing kindlin 1 | Sometimes (5–29%) | In 1 condition |
| FOXC1forkhead box C1 | Sometimes (5–29%) | In 1 condition |
| KAT6Blysine acetyltransferase 6B | Sometimes (5–29%) | In 1 condition |
| PIGNphosphatidylinositol glycan anchor biosynthesis class N | Sometimes (5–29%) | In 2 conditions |
| PITX2paired like homeodomain 2 | Sometimes (5–29%) | In 2 conditions |
| SNRPBsmall nuclear ribonucleoprotein polypeptides B and B1 | Sometimes (5–29%) | In 1 condition |
| AMER1APC membrane recruitment protein 1 | Rarely (1–4%) | In 1 condition |
| CDH11cadherin 11 | Rarely (1–4%) | In 1 condition |
| RMRPRNA component of mitochondrial RNA processing endoribonuclease | Rarely (1–4%) | In 1 condition |
| CHD7chromodomain helicase DNA binding protein 7 | Not recorded | In 1 condition |
| KDM6Alysine demethylase 6A | Not recorded | In 1 condition |
| KMT2Dlysine methyltransferase 2D | Not recorded | In 1 condition |
| MED12mediator complex subunit 12 | Not recorded | In 1 condition |
| SALL1spalt like transcription factor 1 | Not recorded | In 1 condition |
| SALL4spalt like transcription factor 4 | Not recorded | In 1 condition |
| SMOsmoothened, frizzled class receptor | Not recorded | In 1 condition |
| TBX3T-box transcription factor 3 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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