Trait
Both sided cleft lip
Clinical name: Bilateral cleft lip
A non-midline cleft of the upper lip on the left and right sides.
Summary
- Also called
- Right and left cleft lip, Bilateral cheiloschisis
- Body system
- Abnormality of head or neck
Reference genomeGRCh38hg38
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Read the genes linked to Both sided cleft lip, and the rest of your genome, with one test.
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Get my Genome Test24 genes linked to Both sided cleft lip
Changes in these genes cause rare conditions in which Both sided cleft lip is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AMOTL1angiomotin like 1 | Always | In 1 condition |
| CHUKcomponent of inhibitor of nuclear factor kappa B kinase complex | Always | In 1 condition |
| DLX4distal-less homeobox 4 | Always | In 1 condition |
| RAB5IFRAB5 interacting factor | Always | In 1 condition |
| TP63tumor protein p63 | Always | In 2 conditions |
| UGGT1UDP-glucose glycoprotein glucosyltransferase 1 | Always | In 1 condition |
| HYAL2hyaluronidase 2 | Very often (80–99%) | In 1 condition |
| CILK1ciliogenesis associated kinase 1 | Often (30–79%) | In 1 condition |
| FZD2frizzled class receptor 2 | Often (30–79%) | In 1 condition |
| MED12mediator complex subunit 12 | Often (30–79%) | In 1 condition |
| RSPO2R-spondin 2 | Often (30–79%) | In 1 condition |
| SIX3SIX homeobox 3 | Often (30–79%) | In 1 condition |
| B3GLCTbeta 3-glucosyltransferase | Sometimes (5–29%) | In 1 condition |
| GLI2GLI family zinc finger 2 | Sometimes (5–29%) | In 1 condition |
| IRF6interferon regulatory factor 6 | Sometimes (5–29%) | In 1 condition |
| MAU2MAU2 sister chromatid cohesion factor | Sometimes (5–29%) | In 1 condition |
| MSX1msh homeobox 1 | Sometimes (5–29%) | In 1 condition |
| NECTIN1nectin cell adhesion molecule 1 | Sometimes (5–29%) | In 1 condition |
| PTCH1patched 1 | Sometimes (5–29%) | In 1 condition |
| SMPD4sphingomyelin phosphodiesterase 4 | Sometimes (5–29%) | In 1 condition |
| SPOPspeckle type BTB/POZ protein | Sometimes (5–29%) | In 1 condition |
| TAF11TATA-box binding protein associated factor 11 | Sometimes (5–29%) | In 1 condition |
| PTBP1polypyrimidine tract binding protein 1 | Rarely (1–4%) | In 1 condition |
| CDH1cadherin 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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