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Trait
Decreased salivary flow
Clinical name: Xerostomia
Dryness of the mouth due to salivary gland dysfunction.
Summary
- Also called
- Dry mouth, Dry mouth syndrome, Reduced salivation
- Body system
- Abnormality of head or neck
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This page as data
Add .json to the page's address, or ask for application/json, to read it as JSON.
library(jsonlite)
url <- "https://dantelabs.com/traits/xerostomia.json"
page <- fromJSON(url)
page$trait$nameDecreased salivary flowHP:0000217
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Get my Genome Test53 genes linked to Decreased salivary flow
Changes in these genes cause rare conditions in which Decreased salivary flow is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CHRM3cholinergic receptor muscarinic 3 | Always | In 1 condition |
| CLDN10claudin 10 | Always | In 1 condition |
| EDARADDEDAR associated via death domain | Always | In 1 condition |
| PLD4phospholipase D family member 4 | Always | In 1 condition |
| SLC12A2solute carrier family 12 member 2 | Always | In 1 condition |
| ANGangiogenin | Often (30–79%) | In 1 condition |
| ANXA11annexin A11 | Often (30–79%) | In 1 condition |
| ATXN2ataxin 2 | Often (30–79%) | In 1 condition |
| CAV1caveolin 1 | Often (30–79%) | In 1 condition |
| CCN2cellular communication network factor 2 | Often (30–79%) | In 1 condition |
| CCNFcyclin F | Often (30–79%) | In 1 condition |
| CCR6C-C motif chemokine receptor 6 | Often (30–79%) | In 1 condition |
| CFAP410cilia and flagella associated protein 410 | Often (30–79%) | In 1 condition |
| CHCHD10coiled-coil-helix-coiled-coil-helix domain containing 10 | Often (30–79%) | In 1 condition |
| CHMP2Bcharged multivesicular body protein 2B | Often (30–79%) | In 1 condition |
| DAOD-amino acid oxidase | Often (30–79%) | In 1 condition |
| DCTN1dynactin subunit 1 | Often (30–79%) | In 1 condition |
| ELOVL1ELOVL fatty acid elongase 1 | Often (30–79%) | In 1 condition |
| ERBB4erb-b2 receptor tyrosine kinase 4 | Often (30–79%) | In 1 condition |
| FGF10fibroblast growth factor 10 | Often (30–79%) | In 3 conditions |
| FGFR2fibroblast growth factor receptor 2 | Often (30–79%) | In 2 conditions |
| FGFR3fibroblast growth factor receptor 3 | Often (30–79%) | In 1 condition |
| FIG4FIG4 phosphoinositide 5-phosphatase | Often (30–79%) | In 1 condition |
| FUSFUS RNA binding protein | Often (30–79%) | In 1 condition |
| GLE1GLE1 RNA export mediator | Often (30–79%) | In 1 condition |
| GLT8D1glycosyltransferase 8 domain containing 1 | Often (30–79%) | In 1 condition |
| GSNgelsolin | Often (30–79%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Often (30–79%) | In 1 condition |
| HNRNPA1heterogeneous nuclear ribonucleoprotein A1 | Often (30–79%) | In 1 condition |
| IRF5interferon regulatory factor 5 | Often (30–79%) | In 1 condition |
| LBRlamin B receptor | Often (30–79%) | In 1 condition |
| LRP12LDL receptor related protein 12 | Often (30–79%) | In 1 condition |
| MATR3matrin 3 | Often (30–79%) | In 1 condition |
| NEFHneurofilament heavy chain | Often (30–79%) | In 1 condition |
| NEK1NIMA related kinase 1 | Often (30–79%) | In 1 condition |
| OPTNoptineurin | Often (30–79%) | In 1 condition |
| PFN1profilin 1 | Often (30–79%) | In 1 condition |
| PRPHperipherin | Often (30–79%) | In 1 condition |
| SOD1superoxide dismutase 1 | Often (30–79%) | In 1 condition |
| SQSTM1sequestosome 1 | Often (30–79%) | In 1 condition |
Show 13 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| TAF15TATA-box binding protein associated factor 15 | Often (30–79%) | In 1 condition |
| TARDBPTAR DNA binding protein | Often (30–79%) | In 1 condition |
| TBK1TANK binding kinase 1 | Often (30–79%) | In 1 condition |
| TREM2triggering receptor expressed on myeloid cells 2 | Often (30–79%) | In 1 condition |
| UBQLN2ubiquilin 2 | Often (30–79%) | In 1 condition |
| UNC13Aunc-13 homolog A | Often (30–79%) | In 1 condition |
| VAPBVAMP associated protein B and C | Often (30–79%) | In 1 condition |
| VCPvalosin containing protein | Often (30–79%) | In 1 condition |
| MAGEL2MAGE family member L2 | Sometimes (5–29%) | In 1 condition |
| NOD2nucleotide binding oligomerization domain containing 2 | Sometimes (5–29%) | In 2 conditions |
| SIM1SIM bHLH transcription factor 1 | Sometimes (5–29%) | In 1 condition |
| TP63tumor protein p63 | Sometimes (5–29%) | In 2 conditions |
| SCN9Asodium voltage-gated channel alpha subunit 9 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.17-8666dff2.
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