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Trait
Chewing difficulties
Clinical name: Impaired mastication
An abnormal reduction in the ability to masticate (chew), i.e., in the ability to crush and ground food in preparation for swallowing.
Summary
- Also called
- Chewing difficulty, Difficulty chewing
- Body system
- Abnormality of head or neck
Chewing difficultiesHP:0005216
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Read the genes linked to Chewing difficulties, and the rest of your genome, with one test.
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Get my Genome Test52 genes linked to Chewing difficulties
Changes in these genes cause rare conditions in which Chewing difficulties is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AHDC1AT-hook DNA binding motif containing 1 | Always | In 1 condition |
| HOXB1homeobox B1 | Always | In 1 condition |
| SLC39A14solute carrier family 39 member 14 | Always | In 1 condition |
| ALS2alsin Rho guanine nucleotide exchange factor ALS2 | Very often (80–99%) | In 2 conditions |
| EDAectodysplasin A | Very often (80–99%) | In 1 condition |
| EDARADDEDAR associated via death domain | Very often (80–99%) | In 1 condition |
| FGFR1fibroblast growth factor receptor 1 | Very often (80–99%) | In 1 condition |
| GREM2gremlin 2, DAN family BMP antagonist | Very often (80–99%) | In 1 condition |
| HLA-Bmajor histocompatibility complex, class I, B | Very often (80–99%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Very often (80–99%) | In 1 condition |
| IRF6interferon regulatory factor 6 | Very often (80–99%) | In 2 conditions |
| LRP6LDL receptor related protein 6 | Very often (80–99%) | In 1 condition |
| MSX1msh homeobox 1 | Very often (80–99%) | In 2 conditions |
| P4HA2prolyl 4-hydroxylase subunit alpha 2 | Very often (80–99%) | In 1 condition |
| PAX9paired box 9 | Very often (80–99%) | In 1 condition |
| PTPN22protein tyrosine phosphatase non-receptor type 22 | Very often (80–99%) | In 1 condition |
| SUMO1small ubiquitin like modifier 1 | Very often (80–99%) | In 1 condition |
| TGFAtransforming growth factor alpha | Very often (80–99%) | In 1 condition |
| WNT10AWnt family member 10A | Very often (80–99%) | In 1 condition |
| WNT10BWnt family member 10B | Very often (80–99%) | In 1 condition |
| LAMA2laminin subunit alpha 2 | Often (30–79%) | In 1 condition |
| MTRFRmitochondrial translation release factor in rescue | Often (30–79%) | In 2 conditions |
| NECTIN1nectin cell adhesion molecule 1 | Often (30–79%) | In 1 condition |
| NEUROG1neurogenin 1 | Often (30–79%) | In 1 condition |
| TP63tumor protein p63 | Often (30–79%) | In 1 condition |
| ACTA1actin alpha 1, skeletal muscle | Sometimes (5–29%) | In 1 condition |
| ADNPactivity dependent neuroprotector homeobox | Sometimes (5–29%) | In 1 condition |
| CHRNA1cholinergic receptor nicotinic alpha 1 subunit | Sometimes (5–29%) | In 1 condition |
| COL13A1collagen type XIII alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| COLQcollagen like tail subunit of asymmetric acetylcholinesterase | Sometimes (5–29%) | In 1 condition |
| FARS2phenylalanyl-tRNA synthetase 2, mitochondrial | Sometimes (5–29%) | In 1 condition |
| GRIN1glutamate ionotropic receptor NMDA type subunit 1 | Sometimes (5–29%) | In 1 condition |
| H4C5H4 clustered histone 5 | Sometimes (5–29%) | In 1 condition |
| HACD13-hydroxyacyl-CoA dehydratase 1 | Sometimes (5–29%) | In 1 condition |
| ITGA7integrin subunit alpha 7 | Sometimes (5–29%) | In 1 condition |
| LAMB2laminin subunit beta 2 | Sometimes (5–29%) | In 1 condition |
| LPIN1lipin 1 | Sometimes (5–29%) | In 1 condition |
| MAP3K20mitogen-activated protein kinase kinase kinase 20 | Sometimes (5–29%) | In 1 condition |
| MT-CO1mitochondrially encoded cytochrome c oxidase I | Sometimes (5–29%) | In 1 condition |
| MT-CO3mitochondrially encoded cytochrome c oxidase III | Sometimes (5–29%) | In 1 condition |
Show 12 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| MYL2myosin light chain 2 | Sometimes (5–29%) | In 1 condition |
| NAA20N-alpha-acetyltransferase 20, NatB catalytic subunit | Sometimes (5–29%) | In 1 condition |
| OBSCNobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | Sometimes (5–29%) | In 1 condition |
| PYROXD1pyridine nucleotide-disulphide oxidoreductase domain 1 | Sometimes (5–29%) | In 1 condition |
| SELENONselenoprotein N | Sometimes (5–29%) | In 1 condition |
| TPM2tropomyosin 2 | Sometimes (5–29%) | In 1 condition |
| TPM3tropomyosin 3 | Sometimes (5–29%) | In 1 condition |
| TUBB3tubulin beta 3 class III | Sometimes (5–29%) | In 1 condition |
| ADSS1adenylosuccinate synthase 1 | Rarely (1–4%) | In 1 condition |
| PPP2R5Dprotein phosphatase 2 regulatory subunit B'delta | Rarely (1–4%) | In 1 condition |
| PYGMglycogen phosphorylase, muscle associated | Rarely (1–4%) | In 1 condition |
| GNAI3G protein subunit alpha i3 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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