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Gene

FIGLA

folliculogenesis specific bHLH transcription factor

Summary

Cytogenetic location
2p13.3
Coordinates
Chromosome 2: 70,777,310–70,790,643 (GRCh38)
Exons
5 exons across 13.3 kb
Protein
219 amino acids
Also known as
bHLHc8, Figalpha
MANE Select transcript
ENST00000332372.6NM_001004311.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Female Infertility

    • Diminished or absent ability of a female to achieve conception.

      • 1 GenCC submitter rates it definitive or strong

How FIGLA is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 2, with a bracket where FIGLA sits. FIGLA and 16 genes near it on chromosome 2, from 70,283,977 to 71,283,976.Chromosome 22p13.3p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.370.4 Mb70.6 Mb70.8 Mb71 Mb71.2 MbSNRPG: 70,281,204–70,293,766, reverse strandSNRPGTIMCC: 70,295,975–70,302,086, reverse strandTIMCCTGFA: 70,447,284–70,554,193, reverse strandTGFAADD2: 70,607,618–70,768,499, reverse strandADD2FIGLA: 70,777,310–70,790,643, reverse strandFIGLACLEC4F: 70,808,643–70,820,601, reverse strandCLEC4FCD207: 70,830,000–70,835,822, reverse strandCD207VAX2: 70,900,488–70,965,431, forward strandVAX2ATP6V1B1: 70,935,771–70,965,431, forward strandATP6V1B1: 70,939,318–70,995,336, reverse strandTEX261: 70,968,325–70,994,873, reverse strandTEX261ANKRD53: 70,978,380–70,985,967, forward strandNAGK: 71,064,344–71,079,808, forward strandNAGKMCEE: 71,108,926–71,130,279, reverse strandMCEEMPHOSPH10: 71,130,305–71,150,101, forward strandMPHOSPH10PAIP2B: 71,181,702–71,227,112, reverse strandPAIP2BZNF638: 71,276,537–71,437,183, forward strandZNF638Diagram of FIGLA: 5 exons on the reverse strand of chromosome 2Exon 1: 1 known disease-causing siteExon 5: 70,777,310–70,777,382, 73 basesExon 4: 70,777,637–70,777,671, 35 basesExon 3: 70,785,415–70,785,639, 225 basesExon 2: 70,787,649–70,787,801, 153 basesExon 1: 70,790,408–70,790,643, 236 bases543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 0.7 kb of the gene's 13.3 kb; 660 of those bases code for the protein.

How a genome test reads FIGLA

1

position in FIGLA where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 13.3 kb of FIGLA, introns included, not only the 0.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). FIGLA gene: folliculogenesis specific bHLH transcription factor. Retrieved 16 October 2026, from https://dantelabs.com/genes/figla

Vancouver

Dante Labs. FIGLA gene: folliculogenesis specific bHLH transcription factor [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/figla

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