Trait

Submucous cleft soft palate

A cleft of the muscular (soft) portion of the palate that is covered by mucous membrane. Soft-palate submucous clefts are characterized by a midline deficiency or lack of muscle tissue.

HPO HP:0011819

Also called: Partial thickness cleft soft palate, Submucous cleft velum
Body system: Abnormality of head or neck

Read the genes linked to Submucous cleft soft palate, and the rest of your genome, with one test.

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12 genes linked to Submucous cleft soft palate

Changes in these genes cause rare conditions in which Submucous cleft soft palate is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
KCNK9potassium two pore domain channel subfamily K member 9	Often (30–79%)	In 1 condition
NEK1NIMA related kinase 1	Often (30–79%)	In 1 condition
NONOnon-POU domain containing octamer binding	Often (30–79%)	In 1 condition
POLR3ARNA polymerase III subunit A	Often (30–79%)	In 1 condition
DONSONDNA replication fork stabilization factor DONSON	Sometimes (5–29%)	In 1 condition
GRHL3grainyhead like transcription factor 3	Sometimes (5–29%)	In 1 condition
IPO8importin 8	Sometimes (5–29%)	In 1 condition
SONSON DNA and RNA binding protein	Sometimes (5–29%)	In 1 condition
STAC3SH3 and cysteine rich domain 3	Sometimes (5–29%)	In 1 condition
TP63tumor protein p63	Sometimes (5–29%)	In 1 condition
UBBubiquitin B	Sometimes (5–29%)	In 1 condition
ZSWIM6zinc finger SWIM-type containing 6	Sometimes (5–29%)	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Cleft soft palate Submucous cleft palate

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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