Trait
Abnormality of the nail
Clinical name: Abnormal nail morphology
Abnormal structure or appearance of the nail.
Summary
- Also called
- Nail disease
- Body system
- Abnormality of the integument
Reference genomeGRCh38hg38
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Get my Genome Test85 genes linked to Abnormality of the nail
Changes in these genes cause rare conditions in which Abnormality of the nail is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| LAMC2laminin subunit gamma 2 | Always | In 2 conditions |
| ACANaggrecan | Very often (80–99%) | In 1 condition |
| AP1S3adaptor related protein complex 1 subunit sigma 3 | Very often (80–99%) | In 1 condition |
| ATP2A2ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 | Very often (80–99%) | In 1 condition |
| CLEC7AC-type lectin domain containing 7A | Very often (80–99%) | In 1 condition |
| DSG4desmoglein 4 | Very often (80–99%) | In 1 condition |
| DYNC2LI1dynein cytoplasmic 2 light intermediate chain 1 | Very often (80–99%) | In 1 condition |
| EVCEvC ciliary complex subunit 1 | Very often (80–99%) | In 1 condition |
| EVC2EvC ciliary complex subunit 2 | Very often (80–99%) | In 1 condition |
| GJA1gap junction protein alpha 1 | Very often (80–99%) | In 3 conditions |
| GLI1GLI family zinc finger 1 | Very often (80–99%) | In 1 condition |
| HLA-Bmajor histocompatibility complex, class I, B | Very often (80–99%) | In 1 condition |
| IL17Finterleukin 17F | Very often (80–99%) | In 1 condition |
| IL17RAinterleukin 17 receptor A | Very often (80–99%) | In 1 condition |
| IL17RCinterleukin 17 receptor C | Very often (80–99%) | In 1 condition |
| IL36RNinterleukin 36 receptor antagonist | Very often (80–99%) | In 1 condition |
| KRT81keratin 81 | Very often (80–99%) | In 1 condition |
| KRT83keratin 83 | Very often (80–99%) | In 1 condition |
| KRT86keratin 86 | Very often (80–99%) | In 1 condition |
| LAMA3laminin subunit alpha 3 | Very often (80–99%) | In 1 condition |
| LAMB3laminin subunit beta 3 | Very often (80–99%) | In 1 condition |
| LMX1BLIM homeobox transcription factor 1 beta | Very often (80–99%) | In 1 condition |
| MSX1msh homeobox 1 | Very often (80–99%) | In 1 condition |
| PDE4Dphosphodiesterase 4D | Very often (80–99%) | In 1 condition |
| PRKACAprotein kinase cAMP-activated catalytic subunit alpha | Very often (80–99%) | In 1 condition |
| PRKACBprotein kinase cAMP-activated catalytic subunit beta | Very often (80–99%) | In 1 condition |
| PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha | Very often (80–99%) | In 1 condition |
| SLC25A24solute carrier family 25 member 24 | Very often (80–99%) | In 1 condition |
| SMARCAD1SNF2 related chromatin remodeling ATPase with DExD box 1 | Very often (80–99%) | In 1 condition |
| TP63tumor protein p63 | Very often (80–99%) | In 1 condition |
| TRAF3IP2TRAF3 interacting protein 2 | Very often (80–99%) | In 1 condition |
| ABCA12ATP binding cassette subfamily A member 12 | Often (30–79%) | In 1 condition |
| ALOX12Barachidonate 12-lipoxygenase, 12R type | Often (30–79%) | In 1 condition |
| ALOXE3arachidonate epidermal lipoxygenase 3 | Often (30–79%) | In 1 condition |
| CARD14caspase recruitment domain family member 14 | Often (30–79%) | In 1 condition |
| CASRcalcium sensing receptor | Often (30–79%) | In 1 condition |
| CERS3ceramide synthase 3 | Often (30–79%) | In 1 condition |
| CTSCcathepsin C | Often (30–79%) | In 1 condition |
| CTSKcathepsin K | Often (30–79%) | In 1 condition |
| CYB5Acytochrome b5 type A | Often (30–79%) | In 1 condition |
Show 45 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| CYB5R3cytochrome b5 reductase 3 | Often (30–79%) | In 1 condition |
| DLX3distal-less homeobox 3 | Often (30–79%) | In 1 condition |
| DSG1desmoglein 1 | Often (30–79%) | In 1 condition |
| DSPdesmoplakin | Often (30–79%) | In 1 condition |
| GNA11G protein subunit alpha 11 | Often (30–79%) | In 1 condition |
| HGDhomogentisate 1,2-dioxygenase | Often (30–79%) | In 1 condition |
| IFT140intraflagellar transport 140 | Often (30–79%) | In 1 condition |
| IRF6interferon regulatory factor 6 | Often (30–79%) | In 1 condition |
| KRT1keratin 1 | Often (30–79%) | In 1 condition |
| LMNAlamin A/C | Often (30–79%) | In 2 conditions |
| MAP3K20mitogen-activated protein kinase kinase kinase 20 | Often (30–79%) | In 1 condition |
| MBTPS2membrane bound transcription factor peptidase, site 2 | Often (30–79%) | In 1 condition |
| NIPAL4NIPA like domain containing 4 | Often (30–79%) | In 1 condition |
| PNPLA1patatin like domain 1, omega-hydroxyceramide transacylase | Often (30–79%) | In 1 condition |
| SDR9C7short chain dehydrogenase/reductase family 9C member 7 | Often (30–79%) | In 1 condition |
| SLC39A4solute carrier family 39 member 4 | Often (30–79%) | In 1 condition |
| SULT2B1sulfotransferase family 2B member 1 | Often (30–79%) | In 1 condition |
| TGM1transglutaminase 1 | Often (30–79%) | In 1 condition |
| ADNPactivity dependent neuroprotector homeobox | Sometimes (5–29%) | In 1 condition |
| AKT1AKT serine/threonine kinase 1 | Sometimes (5–29%) | In 1 condition |
| CD28CD28 molecule | Sometimes (5–29%) | In 1 condition |
| COX7Bcytochrome c oxidase subunit 7B | Sometimes (5–29%) | In 1 condition |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Sometimes (5–29%) | In 1 condition |
| EBPEBP cholestenol delta-isomerase | Sometimes (5–29%) | In 1 condition |
| FBXO22F-box protein 22 | Sometimes (5–29%) | In 1 condition |
| FGF9fibroblast growth factor 9 | Sometimes (5–29%) | In 1 condition |
| FGFR2fibroblast growth factor receptor 2 | Sometimes (5–29%) | In 1 condition |
| FUCA1alpha-L-fucosidase 1 | Sometimes (5–29%) | In 1 condition |
| GDF5growth differentiation factor 5 | Sometimes (5–29%) | In 1 condition |
| GDF6growth differentiation factor 6 | Sometimes (5–29%) | In 1 condition |
| GJB2gap junction protein beta 2 | Sometimes (5–29%) | In 1 condition |
| GJB3gap junction protein beta 3 | Sometimes (5–29%) | In 1 condition |
| GJB4gap junction protein beta 4 | Sometimes (5–29%) | In 1 condition |
| HCCSholocytochrome c synthase | Sometimes (5–29%) | In 1 condition |
| HRHR lysine demethylase and nuclear receptor corepressor | Sometimes (5–29%) | In 1 condition |
| KDSR3-ketodihydrosphingosine reductase | Sometimes (5–29%) | In 1 condition |
| LEF1lymphoid enhancer binding factor 1 | Sometimes (5–29%) | In 1 condition |
| NDUFB11NADH:ubiquinone oxidoreductase subunit B11 | Sometimes (5–29%) | In 1 condition |
| NOGnoggin | Sometimes (5–29%) | In 1 condition |
| TATtyrosine aminotransferase | Sometimes (5–29%) | In 1 condition |
| TNFRSF1BTNF receptor superfamily member 1B | Sometimes (5–29%) | In 1 condition |
| TREX1three prime repair exonuclease 1 | Sometimes (5–29%) | In 1 condition |
| CDSNcorneodesmosin | Not recorded | In 1 condition |
| KRT74keratin 74 | Not recorded | In 1 condition |
| UBR1ubiquitin protein ligase E3 component n-recognin 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
- Poor nail formation130 genes
- Abnormal fingernails99 genes
- Atypical nail growth84 genes
- Brittle nails35 genes
- Abnormality of the toenail33 genes
- Thick nail19 genes
- Absent/small nails16 genes
- Thin nail16 genes
- Abnormal periungual morphology3 genes
- Abnormality of nail color3 genes
- Nailfold capillary tortuosity3 genes
- Chronic monilial nail infection2 genes
- Nail bed hemorrhage2 genes
- Nail bed telangiectasia2 genes
- Abnormal subungual morphology1 gene
- Longitudinal erythronychia1 gene
- Onychoheterotopia1 gene
- Pyramidal skinfold extending from the base to the top of the nails1 gene
- Splinter hemorrhages1 gene
- Abnormal nail attachment
- Abnormal nail growth
- Abnormal nail surface
- Nail tumor
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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