Trait
Zygomatic flattening
Clinical name: Malar flattening
Underdevelopment of the malar prominence of the jugal bone (zygomatic bone in mammals), appreciated in profile, frontal view, and/or by palpation.
Summary
- Also called
- Decreased size of malar bone, Depressed malar region, Flat cheekbone, Malar hypoplasia, Underdevelopment of malar bone
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Zygomatic flattening, and the rest of your genome, with one test.
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Get my Genome Test217 genes linked to Zygomatic flattening
Changes in these genes cause rare conditions in which Zygomatic flattening is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ACANaggrecan | Always | In 1 condition |
| ASPHaspartate beta-hydroxylase | Always | In 1 condition |
| BBS7Bardet-Biedl syndrome 7 | Always | In 1 condition |
| CANT1calcium activated nucleotidase 1 | Always | In 1 condition |
| COL11A2collagen type XI alpha 2 chain | Always | In 4 conditions |
| COL2A1collagen type II alpha 1 chain | Always | In 6 conditions |
| FGFR1fibroblast growth factor receptor 1 | Always | In 2 conditions |
| FLVCR1FLVCR choline and heme transporter 1 | Always | In 1 condition |
| FOXP1forkhead box P1 | Always | In 1 condition |
| HNRNPH1heterogeneous nuclear ribonucleoprotein H1 | Always | In 1 condition |
| HS6ST2heparan sulfate 6-O-sulfotransferase 2 | Always | In 1 condition |
| KDM6Blysine demethylase 6B | Always | In 1 condition |
| KIF7kinesin family member 7 | Always | In 1 condition |
| MECP2methyl-CpG binding protein 2 | Always | In 1 condition |
| NONOnon-POU domain containing octamer binding | Always | In 2 conditions |
| NOTCH2notch receptor 2 | Always | In 1 condition |
| NOTCH3notch receptor 3 | Always | In 2 conditions |
| OBSL1obscurin like cytoskeletal adaptor 1 | Always | In 1 condition |
| PIGUphosphatidylinositol glycan anchor biosynthesis class U | Always | In 1 condition |
| PLOD3procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 | Always | In 1 condition |
| POLR1BRNA polymerase I subunit B | Always | In 2 conditions |
| POLR1CRNA polymerase I and III subunit C | Always | In 2 conditions |
| PSMC3proteasome 26S subunit, ATPase 3 | Always | In 1 condition |
| RDH11retinol dehydrogenase 11 | Always | In 2 conditions |
| TBL1XR1TBL1X/Y related 1 | Always | In 2 conditions |
| TMEM165transmembrane protein 165 | Always | In 1 condition |
| ACSL4acyl-CoA synthetase long chain family member 4 | Very often (80–99%) | In 1 condition |
| AMMECR1AMMECR nuclear protein 1 | Very often (80–99%) | In 1 condition |
| ATP6V0A2ATPase H+ transporting V0 subunit a2 | Very often (80–99%) | In 2 conditions |
| ATP6V1AATPase H+ transporting V1 subunit A | Very often (80–99%) | In 1 condition |
| ATP6V1E1ATPase H+ transporting V1 subunit E1 | Very often (80–99%) | In 2 conditions |
| BGNbiglycan | Very often (80–99%) | In 1 condition |
| COG4component of oligomeric golgi complex 4 | Very often (80–99%) | In 1 condition |
| COL11A1collagen type XI alpha 1 chain | Very often (80–99%) | In 4 conditions |
| DHODHdihydroorotate dehydrogenase (quinone) | Very often (80–99%) | In 2 conditions |
| EFTUD2elongation factor Tu GTP binding domain containing 2 | Very often (80–99%) | In 2 conditions |
| ESCO2establishment of sister chromatid cohesion N-acetyltransferase 2 | Very often (80–99%) | In 2 conditions |
| FGFR2fibroblast growth factor receptor 2 | Very often (80–99%) | In 8 conditions |
| FLNAfilamin A | Very often (80–99%) | In 4 conditions |
| FLNBfilamin B | Very often (80–99%) | In 4 conditions |
Show 177 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| HDAC4histone deacetylase 4 | Very often (80–99%) | In 1 condition |
| INPPL1inositol polyphosphate phosphatase like 1 | Very often (80–99%) | In 1 condition |
| KCNE5potassium voltage-gated channel subfamily E regulatory subunit 5 | Very often (80–99%) | In 1 condition |
| LARP7La ribonucleoprotein 7, transcriptional regulator | Very often (80–99%) | In 2 conditions |
| NSDHLNAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL | Very often (80–99%) | In 2 conditions |
| PDE4Dphosphodiesterase 4D | Very often (80–99%) | In 2 conditions |
| POLR1DRNA polymerase I and III subunit D | Very often (80–99%) | In 2 conditions |
| POLR3ARNA polymerase III subunit A | Very often (80–99%) | In 2 conditions |
| PQBP1polyglutamine binding protein 1 | Very often (80–99%) | In 2 conditions |
| PTH1Rparathyroid hormone 1 receptor | Very often (80–99%) | In 2 conditions |
| RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1 | Very often (80–99%) | In 1 condition |
| RAB3GAP2RAB3 GTPase activating non-catalytic protein subunit 2 | Very often (80–99%) | In 1 condition |
| RAI1retinoic acid induced 1 | Very often (80–99%) | In 1 condition |
| RSPRY1ring finger and SPRY domain containing 1 | Very often (80–99%) | In 2 conditions |
| SCARF2scavenger receptor class F member 2 | Very often (80–99%) | In 2 conditions |
| SF3B4splicing factor 3b subunit 4 | Very often (80–99%) | In 2 conditions |
| SLC35D1solute carrier family 35 member D1 | Very often (80–99%) | In 2 conditions |
| TBX22T-box transcription factor 22 | Very often (80–99%) | In 1 condition |
| TCOF1treacle ribosome biogenesis factor 1 | Very often (80–99%) | In 2 conditions |
| TFAP2Btranscription factor AP-2 beta | Very often (80–99%) | In 1 condition |
| TGDSTDP-glucose 4,6-dehydratase | Very often (80–99%) | In 1 condition |
| YY1YY1 transcription factor | Very often (80–99%) | In 2 conditions |
| ZNHIT3zinc finger HIT-type containing 3 | Very often (80–99%) | In 1 condition |
| ADAMTSL4ADAMTS like 4 | Often (30–79%) | In 1 condition |
| ARID1BAT-rich interaction domain 1B | Often (30–79%) | In 1 condition |
| ARVCFARVCF delta catenin family member | Often (30–79%) | In 1 condition |
| BLMBLM RecQ like helicase | Often (30–79%) | In 2 conditions |
| BMP2bone morphogenetic protein 2 | Often (30–79%) | In 1 condition |
| CDH11cadherin 11 | Often (30–79%) | In 1 condition |
| CHD6chromodomain helicase DNA binding protein 6 | Often (30–79%) | In 1 condition |
| COL9A1collagen type IX alpha 1 chain | Often (30–79%) | In 1 condition |
| COL9A2collagen type IX alpha 2 chain | Often (30–79%) | In 1 condition |
| COL9A3collagen type IX alpha 3 chain | Often (30–79%) | In 1 condition |
| COMTcatechol-O-methyltransferase | Often (30–79%) | In 1 condition |
| DLG3discs large MAGUK scaffold protein 3 | Often (30–79%) | In 1 condition |
| DVL1dishevelled segment polarity protein 1 | Often (30–79%) | In 1 condition |
| EHMT1euchromatic histone lysine methyltransferase 1 | Often (30–79%) | In 1 condition |
| FBN1fibrillin 1 | Often (30–79%) | In 2 conditions |
| FGFR3fibroblast growth factor receptor 3 | Often (30–79%) | In 5 conditions |
| FOXC1forkhead box C1 | Often (30–79%) | In 1 condition |
| FZD2frizzled class receptor 2 | Often (30–79%) | In 1 condition |
| GLI2GLI family zinc finger 2 | Often (30–79%) | In 1 condition |
| GP1BBglycoprotein Ib platelet subunit beta | Often (30–79%) | In 1 condition |
| GSCgoosecoid homeobox | Often (30–79%) | In 1 condition |
| HBA1hemoglobin subunit alpha 1 | Often (30–79%) | In 1 condition |
| HBA2hemoglobin subunit alpha 2 | Often (30–79%) | In 1 condition |
| HIRAhistone cell cycle regulator | Often (30–79%) | In 1 condition |
| IPO8importin 8 | Often (30–79%) | In 1 condition |
| JMJD1Cjumonji domain containing 1C | Often (30–79%) | In 1 condition |
| LOXL3lysyl oxidase like 3 | Often (30–79%) | In 1 condition |
| LRP4LDL receptor related protein 4 | Often (30–79%) | In 2 conditions |
| MBD5methyl-CpG binding domain protein 5 | Often (30–79%) | In 1 condition |
| MED12mediator complex subunit 12 | Often (30–79%) | In 1 condition |
| NEK1NIMA related kinase 1 | Often (30–79%) | In 1 condition |
| NGFnerve growth factor | Often (30–79%) | In 1 condition |
| NTRK1neurotrophic receptor tyrosine kinase 1 | Often (30–79%) | In 1 condition |
| PCGF2polycomb group ring finger 2 | Often (30–79%) | In 1 condition |
| PDZD8PDZ domain containing 8 | Often (30–79%) | In 1 condition |
| PIGAphosphatidylinositol glycan anchor biosynthesis class A | Often (30–79%) | In 1 condition |
| POLEDNA polymerase epsilon, catalytic subunit | Often (30–79%) | In 1 condition |
| PRMT7protein arginine methyltransferase 7 | Often (30–79%) | In 1 condition |
| RHOAras homolog family member A | Often (30–79%) | In 1 condition |
| RNU12RNA, U12 small nuclear | Often (30–79%) | In 2 conditions |
| RNU4ATACRNA, U4atac small nuclear | Often (30–79%) | In 1 condition |
| RPL17ribosomal protein L17 | Often (30–79%) | In 1 condition |
| RPS26ribosomal protein S26 | Often (30–79%) | In 1 condition |
| RREB1ras responsive element binding protein 1 | Often (30–79%) | In 1 condition |
| RUNX2RUNX family transcription factor 2 | Often (30–79%) | In 1 condition |
| SEC24CSEC24 homolog C, COPII component | Often (30–79%) | In 1 condition |
| SETD2SET domain containing 2, histone lysine methyltransferase | Often (30–79%) | In 2 conditions |
| SHANK3SH3 and multiple ankyrin repeat domains 3 | Often (30–79%) | In 1 condition |
| SLC2A10solute carrier family 2 member 10 | Often (30–79%) | In 2 conditions |
| SLC6A8solute carrier family 6 member 8 | Often (30–79%) | In 2 conditions |
| SMAD2SMAD family member 2 | Often (30–79%) | In 1 condition |
| SMAD3SMAD family member 3 | Often (30–79%) | In 3 conditions |
| STAG2STAG2 cohesin complex component | Often (30–79%) | In 1 condition |
| TBX1T-box transcription factor 1 | Often (30–79%) | In 1 condition |
| TFE3transcription factor binding to IGHM enhancer 3 | Often (30–79%) | In 1 condition |
| TGFB2transforming growth factor beta 2 | Often (30–79%) | In 1 condition |
| TGFB3transforming growth factor beta 3 | Often (30–79%) | In 1 condition |
| TGFBR1transforming growth factor beta receptor 1 | Often (30–79%) | In 2 conditions |
| TGFBR2transforming growth factor beta receptor 2 | Often (30–79%) | In 2 conditions |
| TRIM33tripartite motif containing 33 | Often (30–79%) | In 1 condition |
| UBE2Aubiquitin conjugating enzyme E2 A | Often (30–79%) | In 1 condition |
| UFD1ubiquitin recognition factor in ER associated degradation 1 | Often (30–79%) | In 1 condition |
| WNT5AWnt family member 5A | Often (30–79%) | In 1 condition |
| APCAPC regulator of Wnt signaling pathway | Sometimes (5–29%) | In 1 condition |
| ASXL3ASXL transcriptional regulator 3 | Sometimes (5–29%) | In 1 condition |
| BCRBCR activator of RhoGEF and GTPase | Sometimes (5–29%) | In 1 condition |
| CDK10cyclin dependent kinase 10 | Sometimes (5–29%) | In 1 condition |
| CNOT3CCR4-NOT transcription complex subunit 3 | Sometimes (5–29%) | In 1 condition |
| COL5A1collagen type V alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| CRELD1CRELD disulfide isomerase 1 | Sometimes (5–29%) | In 1 condition |
| CRKLCRK like proto-oncogene, adaptor protein | Sometimes (5–29%) | In 1 condition |
| ELNelastin | Sometimes (5–29%) | In 1 condition |
| ERFETS2 repressor factor | Sometimes (5–29%) | In 1 condition |
| FAM50Afamily with sequence similarity 50 member A | Sometimes (5–29%) | In 1 condition |
| GORABgolgin, RAB6 interacting | Sometimes (5–29%) | In 2 conditions |
| GRIA3glutamate ionotropic receptor AMPA type subunit 3 | Sometimes (5–29%) | In 1 condition |
| HERC1HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | Sometimes (5–29%) | In 2 conditions |
| KCNH1potassium voltage-gated channel subfamily H member 1 | Sometimes (5–29%) | In 1 condition |
| LTBP4latent transforming growth factor beta binding protein 4 | Sometimes (5–29%) | In 1 condition |
| MAN1B1mannosidase alpha class 1B member 1 | Sometimes (5–29%) | In 2 conditions |
| MAPK1mitogen-activated protein kinase 1 | Sometimes (5–29%) | In 1 condition |
| MLXIPLMLX interacting protein like | Sometimes (5–29%) | In 1 condition |
| NDPnorrin cystine knot growth factor NDP | Sometimes (5–29%) | In 1 condition |
| NF1neurofibromin 1 | Sometimes (5–29%) | In 2 conditions |
| NPR3natriuretic peptide receptor 3 | Sometimes (5–29%) | In 1 condition |
| PIGTphosphatidylinositol glycan anchor biosynthesis class T | Sometimes (5–29%) | In 1 condition |
| PIK3R1phosphoinositide-3-kinase regulatory subunit 1 | Sometimes (5–29%) | In 1 condition |
| POGZpogo transposable element derived with ZNF domain | Sometimes (5–29%) | In 2 conditions |
| PYCR1pyrroline-5-carboxylate reductase 1 | Sometimes (5–29%) | In 2 conditions |
| RBM8ARNA binding motif protein 8A | Sometimes (5–29%) | In 1 condition |
| RFX7regulatory factor X7 | Sometimes (5–29%) | In 1 condition |
| TATtyrosine aminotransferase | Sometimes (5–29%) | In 1 condition |
| TBX4T-box transcription factor 4 | Sometimes (5–29%) | In 1 condition |
| ZFXzinc finger protein X-linked | Sometimes (5–29%) | In 1 condition |
| GJA5gap junction protein alpha 5 | Rarely (1–4%) | In 1 condition |
| GJA8gap junction protein alpha 8 | Rarely (1–4%) | In 1 condition |
| TP63tumor protein p63 | Rarely (1–4%) | In 2 conditions |
| AGLamylo-alpha-1,6-glucosidase and 4-alpha-glucanotransferase | Not recorded | In 1 condition |
| AIFM1apoptosis inducing factor mitochondria associated 1 | Not recorded | In 1 condition |
| ATRXATRX chromatin remodeler | Not recorded | In 2 conditions |
| B3GALT6beta-1,3-galactosyltransferase 6 | Not recorded | In 1 condition |
| BUB1BBUB1 mitotic checkpoint serine/threonine kinase B | Not recorded | In 1 condition |
| CCBE1collagen and calcium binding EGF domains 1 | Not recorded | In 1 condition |
| CHD7chromodomain helicase DNA binding protein 7 | Not recorded | In 1 condition |
| COL1A1collagen type I alpha 1 chain | Not recorded | In 1 condition |
| CUL7cullin 7 | Not recorded | In 1 condition |
| DCHS1dachsous cadherin-related 1 | Not recorded | In 1 condition |
| DDR2discoidin domain receptor tyrosine kinase 2 | Not recorded | In 1 condition |
| DNMT3BDNA methyltransferase 3 beta | Not recorded | In 1 condition |
| EBPEBP cholestenol delta-isomerase | Not recorded | In 1 condition |
| FAM20CFAM20C golgi associated secretory pathway kinase | Not recorded | In 1 condition |
| FAT4FAT atypical cadherin 4 | Not recorded | In 1 condition |
| GPC6glypican 6 | Not recorded | In 1 condition |
| HSPG2heparan sulfate proteoglycan 2 | Not recorded | In 2 conditions |
| KCNJ2potassium inwardly rectifying channel subfamily J member 2 | Not recorded | In 1 condition |
| KIF22kinesin family member 22 | Not recorded | In 1 condition |
| LIFRLIF receptor subunit alpha | Not recorded | In 1 condition |
| LMNAlamin A/C | Not recorded | In 1 condition |
| LRP2LDL receptor related protein 2 | Not recorded | In 1 condition |
| LRPPRCleucine rich pentatricopeptide repeat containing | Not recorded | In 1 condition |
| MAFMAF bZIP transcription factor | Not recorded | In 1 condition |
| MAN2B1mannosidase alpha class 2B member 1 | Not recorded | In 1 condition |
| MGPmatrix Gla protein | Not recorded | In 1 condition |
| MYH3myosin heavy chain 3 | Not recorded | In 1 condition |
| NECTIN1nectin cell adhesion molecule 1 | Not recorded | In 1 condition |
| PAX3paired box 3 | Not recorded | In 1 condition |
| PEX1peroxisomal biogenesis factor 1 | Not recorded | In 1 condition |
| PEX12peroxisomal biogenesis factor 12 | Not recorded | In 1 condition |
| PEX7peroxisomal biogenesis factor 7 | Not recorded | In 1 condition |
| PIGBphosphatidylinositol glycan anchor biosynthesis class B | Not recorded | In 1 condition |
| PIGVphosphatidylinositol glycan anchor biosynthesis class V | Not recorded | In 1 condition |
| POMGNT1protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) | Not recorded | In 1 condition |
| PORcytochrome p450 oxidoreductase | Not recorded | In 2 conditions |
| POU1F1POU class 1 homeobox 1 | Not recorded | In 1 condition |
| PYCR2pyrroline-5-carboxylate reductase 2 | Not recorded | In 1 condition |
| RAB23RAB23, member RAS oncogene family | Not recorded | In 1 condition |
| RLIMring finger protein, LIM domain interacting | Not recorded | In 1 condition |
| ROR2ROR family WNT receptor 2 | Not recorded | In 1 condition |
| SATB2SATB homeobox 2 | Not recorded | In 1 condition |
| SEC23ASEC23 homolog A, COPII component | Not recorded | In 1 condition |
| SERPINH1serpin family H member 1 | Not recorded | In 1 condition |
| SETBP1SET binding protein 1 | Not recorded | In 1 condition |
| SF3B2splicing factor 3b subunit 2 | Not recorded | In 1 condition |
| SHHsonic hedgehog signaling molecule | Not recorded | In 1 condition |
| SIX3SIX homeobox 3 | Not recorded | In 1 condition |
| SLC26A2solute carrier family 26 member 2 | Not recorded | In 2 conditions |
| SMAD4SMAD family member 4 | Not recorded | In 1 condition |
| SNRPBsmall nuclear ribonucleoprotein polypeptides B and B1 | Not recorded | In 1 condition |
| SOSTsclerostin | Not recorded | In 1 condition |
| TFAP2Atranscription factor AP-2 alpha | Not recorded | In 1 condition |
| TMEM237transmembrane protein 237 | Not recorded | In 1 condition |
| TONSLtonsoku like, DNA repair protein | Not recorded | In 1 condition |
| TWIST1twist family bHLH transcription factor 1 | Not recorded | In 2 conditions |
| ZBTB20zinc finger and BTB domain containing 20 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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