Trait
Chronic infections of the middle ear
Clinical name: Chronic otitis media
Chronic otitis media refers to fluid, swelling, or infection of the middle ear that does not heal and may cause permanent damage to the ear.
Summary
- Also called
- Chronic middle ear infection, Otitis media, chronic
Reference genomeGRCh38hg38
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Read the genes linked to Chronic infections of the middle ear, and the rest of your genome, with one test.
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Get my Genome Test142 genes linked to Chronic infections of the middle ear
Changes in these genes cause rare conditions in which Chronic infections of the middle ear is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AHDC1AT-hook DNA binding motif containing 1 | Always | In 1 condition |
| BORCS8BLOC-1 related complex subunit 8 | Always | In 1 condition |
| DNAAF2dynein axonemal assembly factor 2 | Always | In 2 conditions |
| DNAAF6dynein axonemal assembly factor 6 | Always | In 2 conditions |
| DNAI1dynein axonemal intermediate chain 1 | Always | In 2 conditions |
| DNAI2dynein axonemal intermediate chain 2 | Always | In 2 conditions |
| DNAL1dynein axonemal light chain 1 | Always | In 2 conditions |
| ODAD4outer dynein arm docking complex subunit 4 | Always | In 2 conditions |
| AK2adenylate kinase 2 | Very often (80–99%) | In 1 condition |
| BLNKB cell linker | Very often (80–99%) | In 1 condition |
| BTKBruton tyrosine kinase | Very often (80–99%) | In 1 condition |
| CD79ACD79a molecule | Very often (80–99%) | In 1 condition |
| CD79BCD79b molecule | Very often (80–99%) | In 1 condition |
| DOCK8dedicator of cytokinesis 8 | Very often (80–99%) | In 1 condition |
| FMR1fragile X messenger ribonucleoprotein 1 | Very often (80–99%) | In 1 condition |
| IGHMimmunoglobulin heavy constant mu | Very often (80–99%) | In 1 condition |
| IGLL1immunoglobulin lambda like polypeptide 1 | Very often (80–99%) | In 1 condition |
| LRRC8Aleucine rich repeat containing 8 VRAC subunit A | Very often (80–99%) | In 1 condition |
| PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta | Very often (80–99%) | In 1 condition |
| PIK3R1phosphoinositide-3-kinase regulatory subunit 1 | Very often (80–99%) | In 1 condition |
| SPI1Spi-1 proto-oncogene | Very often (80–99%) | In 1 condition |
| TCF3transcription factor 3 | Very often (80–99%) | In 1 condition |
| WASWASP actin nucleation promoting factor | Very often (80–99%) | In 1 condition |
| APC2APC regulator of Wnt signaling pathway 2 | Often (30–79%) | In 1 condition |
| ARVCFARVCF delta catenin family member | Often (30–79%) | In 1 condition |
| BAZ1Bbromodomain adjacent to zinc finger domain 1B | Often (30–79%) | In 1 condition |
| BRWD1bromodomain and WD repeat domain containing 1 | Often (30–79%) | In 1 condition |
| BUD23BUD23 rRNA methyltransferase and ribosome maturation factor | Often (30–79%) | In 1 condition |
| CCDC39coiled-coil domain 39 molecular ruler complex subunit | Often (30–79%) | In 1 condition |
| CCDC40coiled-coil domain 40 molecular ruler complex subunit | Often (30–79%) | In 1 condition |
| CCNOcyclin O | Often (30–79%) | In 1 condition |
| CFAP221cilia and flagella associated protein 221 | Often (30–79%) | In 1 condition |
| CFAP298cilia and flagella associated protein 298 | Often (30–79%) | In 1 condition |
| CFAP300cilia and flagella associated protein 300 | Often (30–79%) | In 2 conditions |
| CFAP45cilia and flagella associated protein 45 | Often (30–79%) | In 1 condition |
| CFAP74cilia and flagella associated protein 74 | Often (30–79%) | In 1 condition |
| CLIP2CAP-Gly domain containing linker protein 2 | Often (30–79%) | In 1 condition |
| CLXNcalaxin | Often (30–79%) | In 1 condition |
| COMTcatechol-O-methyltransferase | Often (30–79%) | In 1 condition |
| DAW1dynein assembly factor with WD repeats 1 | Often (30–79%) | In 1 condition |
Show 102 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| DNAAF1dynein axonemal assembly factor 1 | Often (30–79%) | In 1 condition |
| DNAAF11dynein axonemal assembly factor 11 | Often (30–79%) | In 1 condition |
| DNAAF19dynein axonemal assembly factor 19 | Often (30–79%) | In 1 condition |
| DNAAF3dynein axonemal assembly factor 3 | Often (30–79%) | In 1 condition |
| DNAAF4dynein axonemal assembly factor 4 | Often (30–79%) | In 1 condition |
| DNAAF5dynein axonemal assembly factor 5 | Often (30–79%) | In 1 condition |
| DNAH1dynein axonemal heavy chain 1 | Often (30–79%) | In 1 condition |
| DNAH11dynein axonemal heavy chain 11 | Often (30–79%) | In 1 condition |
| DNAH5dynein axonemal heavy chain 5 | Often (30–79%) | In 1 condition |
| DNAH7dynein axonemal heavy chain 7 | Often (30–79%) | In 1 condition |
| DNAH9dynein axonemal heavy chain 9 | Often (30–79%) | In 1 condition |
| DNAJB13DnaJ heat shock protein family (Hsp40) member B13 | Often (30–79%) | In 1 condition |
| DNAJC30DnaJ heat shock protein family (Hsp40) member C30 | Often (30–79%) | In 1 condition |
| DRC1dynein regulatory complex subunit 1 | Often (30–79%) | In 1 condition |
| DRC2dynein regulatory complex subunit 2 | Often (30–79%) | In 1 condition |
| DRC4dynein regulatory complex subunit 4 | Often (30–79%) | In 1 condition |
| EIF4Heukaryotic translation initiation factor 4H | Often (30–79%) | In 1 condition |
| ELNelastin | Often (30–79%) | In 1 condition |
| FGFR2fibroblast growth factor receptor 2 | Often (30–79%) | In 1 condition |
| FKBP6FKBP prolyl isomerase family member 6 (inactive) | Often (30–79%) | In 1 condition |
| FOXJ1forkhead box J1 | Often (30–79%) | In 1 condition |
| GAS2L2growth arrest specific 2 like 2 | Often (30–79%) | In 1 condition |
| GATA2GATA binding protein 2 | Often (30–79%) | In 1 condition |
| GP1BBglycoprotein Ib platelet subunit beta | Often (30–79%) | In 1 condition |
| GTF2Igeneral transcription factor IIi | Often (30–79%) | In 1 condition |
| GTF2IRD1GTF2I repeat domain containing 1 | Often (30–79%) | In 1 condition |
| GTF2IRD2GTF2I repeat domain containing 2 | Often (30–79%) | In 1 condition |
| HIRAhistone cell cycle regulator | Often (30–79%) | In 1 condition |
| HYDINHYDIN axonemal central pair apparatus protein | Often (30–79%) | In 1 condition |
| IL11RAinterleukin 11 receptor subunit alpha | Often (30–79%) | In 1 condition |
| IRF6interferon regulatory factor 6 | Often (30–79%) | In 1 condition |
| JMJD1Cjumonji domain containing 1C | Often (30–79%) | In 1 condition |
| KDM6Alysine demethylase 6A | Often (30–79%) | In 1 condition |
| KMT2Dlysine methyltransferase 2D | Often (30–79%) | In 1 condition |
| LIMK1LIM domain kinase 1 | Often (30–79%) | In 1 condition |
| LRRC56leucine rich repeat containing 56 | Often (30–79%) | In 1 condition |
| MCIDASmulticiliate differentiation and DNA synthesis associated cell cycle protein | Often (30–79%) | In 1 condition |
| METTL27methyltransferase like 27 | Often (30–79%) | In 1 condition |
| MSX1msh homeobox 1 | Often (30–79%) | In 1 condition |
| NCF1neutrophil cytosolic factor 1 | Often (30–79%) | In 1 condition |
| NECTIN1nectin cell adhesion molecule 1 | Often (30–79%) | In 1 condition |
| NEK10NIMA related kinase 10 | Often (30–79%) | In 1 condition |
| NME5NME/NM23 family member 5 | Often (30–79%) | In 1 condition |
| NME8NME/NM23 family member 8 | Often (30–79%) | In 1 condition |
| NSD1nuclear receptor binding SET domain protein 1 | Often (30–79%) | In 1 condition |
| NXNnucleoredoxin | Often (30–79%) | In 1 condition |
| ODAD1outer dynein arm docking complex subunit 1 | Often (30–79%) | In 1 condition |
| ODAD2outer dynein arm docking complex subunit 2 | Often (30–79%) | In 1 condition |
| ODAD3outer dynein arm docking complex subunit 3 | Often (30–79%) | In 1 condition |
| OFD1OFD1 centriole and centriolar satellite protein | Often (30–79%) | In 2 conditions |
| PGM3phosphoglucomutase 3 | Often (30–79%) | In 1 condition |
| PIGHphosphatidylinositol glycan anchor biosynthesis class H | Often (30–79%) | In 1 condition |
| RAI1retinoic acid induced 1 | Often (30–79%) | In 1 condition |
| RFC2replication factor C subunit 2 | Often (30–79%) | In 1 condition |
| ROR2ROR family WNT receptor 2 | Often (30–79%) | In 1 condition |
| RPGRretinitis pigmentosa GTPase regulator | Often (30–79%) | In 1 condition |
| RREB1ras responsive element binding protein 1 | Often (30–79%) | In 1 condition |
| RSPH1radial spoke head component 1 | Often (30–79%) | In 1 condition |
| RSPH3radial spoke head 3 | Often (30–79%) | In 1 condition |
| RSPH4Aradial spoke head component 4A | Often (30–79%) | In 1 condition |
| RSPH9radial spoke head component 9 | Often (30–79%) | In 2 conditions |
| RUNX2RUNX family transcription factor 2 | Often (30–79%) | In 1 condition |
| SEC24CSEC24 homolog C, COPII component | Often (30–79%) | In 1 condition |
| SHARPINSHANK associated RH domain interactor | Often (30–79%) | In 1 condition |
| SLC25A12solute carrier family 25 member 12 | Often (30–79%) | In 1 condition |
| SPAG1sperm associated antigen 1 | Often (30–79%) | In 1 condition |
| SPEF2sperm flagellar and cilia associated 2 | Often (30–79%) | In 1 condition |
| STAT3signal transducer and activator of transcription 3 | Often (30–79%) | In 1 condition |
| STK36serine/threonine kinase 36 | Often (30–79%) | In 1 condition |
| STX1Asyntaxin 1A | Often (30–79%) | In 1 condition |
| TAF1TATA-box binding protein associated factor 1 | Often (30–79%) | In 2 conditions |
| TAF11TATA-box binding protein associated factor 11 | Often (30–79%) | In 1 condition |
| TBL2transducin beta like 2 | Often (30–79%) | In 1 condition |
| TBX1T-box transcription factor 1 | Often (30–79%) | In 1 condition |
| TGDSTDP-glucose 4,6-dehydratase | Often (30–79%) | In 1 condition |
| TMEM270transmembrane protein 270 | Often (30–79%) | In 1 condition |
| TP63tumor protein p63 | Often (30–79%) | In 1 condition |
| TTC12tetratricopeptide repeat domain 12 | Often (30–79%) | In 1 condition |
| UFD1ubiquitin recognition factor in ER associated degradation 1 | Often (30–79%) | In 1 condition |
| VPS37DVPS37D subunit of ESCRT-I | Often (30–79%) | In 1 condition |
| ZMYND10zinc finger MYND-type containing 10 | Often (30–79%) | In 1 condition |
| AGAaspartylglucosaminidase | Sometimes (5–29%) | In 1 condition |
| ANKRD11ankyrin repeat domain 11 | Sometimes (5–29%) | In 1 condition |
| CARMIL2capping protein regulator and myosin 1 linker 2 | Sometimes (5–29%) | In 1 condition |
| CPLX1complexin 1 | Sometimes (5–29%) | In 1 condition |
| CTBP1C-terminal binding protein 1 | Sometimes (5–29%) | In 1 condition |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Sometimes (5–29%) | In 1 condition |
| FOXN1forkhead box N1 | Sometimes (5–29%) | In 1 condition |
| GNB2G protein subunit beta 2 | Sometimes (5–29%) | In 1 condition |
| HLA-DPA1major histocompatibility complex, class II, DP alpha 1 | Sometimes (5–29%) | In 1 condition |
| HLA-DPB1major histocompatibility complex, class II, DP beta 1 | Sometimes (5–29%) | In 1 condition |
| KAT6Alysine acetyltransferase 6A | Sometimes (5–29%) | In 1 condition |
| LETM1leucine zipper and EF-hand containing transmembrane protein 1 | Sometimes (5–29%) | In 1 condition |
| NELFAnegative elongation factor complex member A | Sometimes (5–29%) | In 1 condition |
| NSD2nuclear receptor binding SET domain protein 2 | Sometimes (5–29%) | In 1 condition |
| OCRLOCRL inositol polyphosphate-5-phosphatase | Sometimes (5–29%) | In 1 condition |
| PIGGphosphatidylinositol glycan anchor biosynthesis class G (EMM blood group) | Sometimes (5–29%) | In 1 condition |
| PRTN3proteinase 3 | Sometimes (5–29%) | In 1 condition |
| PTPN22protein tyrosine phosphatase non-receptor type 22 | Sometimes (5–29%) | In 1 condition |
| TBX4T-box transcription factor 4 | Sometimes (5–29%) | In 1 condition |
| TAP1transporter 1, ATP binding cassette subfamily B member | Not recorded | In 1 condition |
| TP73tumor protein p73 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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